On large-scale pipelines at a water supply capacity of 5-10 m3/s, the bursted flow can reach hundreds to thousands of cubic meters within a few minutes, which could trigger secondary disasters in the densely populated areas. But the accident is hard to be monitored and found, because the leakage flow is often only 1% to 5% of the water supply capacity. This paper presents the simultaneous manometry for the burst and leakage monitoring along the pipelines. The research found that it can alarm timely in 3min to 5min and provide key information such as detonation location and the amount of the explosion leakage. The method has been applied to Xijiang River Diversion Project in China and the water supply capacity is 3.5 million m3/d(40.5m3/s).