Total Knee Replacement (TKR) is an important and in-demand procedure for the aging population of the United States. In recent decades, the number of TKR procedures performed has shown an increase. This pattern is expected to continue in the coming decades. Despite medical advances in orthopedic surgery, a high number of patients, approximately 20%, are dissatisfied with their procedure outcomes. Common causes that are suggested for this dissatisfaction include loosening of the implant components as well as infection. To eliminate loosening as a cause, it is necessary to determine the state of the implant both intra- and post-operatively. Previous research has focused on passively sensing the compartmental loads between the femoral and tibial components. Common methods include using strain gauges or even piezoelectric transducers to measure force. An alternative to this is to perform real-time structural health monitoring (SHM) of the implant to determine changes in the state of the system. A commonly investigated method of SHM, referred to as the electromechanical impedance (EMI) method, involves using the coupled electromechanical properties of piezoelectric transducers to measure the host structure’s condition. The EMI method has already shown promise in aerospace and infrastructure applications, but has seen limited testing for use in the biomechanical field. This work is intended to validate the EMI method for use in detecting damage in cemented bone-implant interfaces, with TKR being used as a case study to specify certain experimental parameters. An experimental setup which represents the various material layers found in a bone-implant interface is created with various damage conditions to determine the ability for a piezoelectric sensor to detect and quantify the change in material state. The objective of this work is to provide validation as well as a foundation on which additional work in SHM of orthopedic implants and structures can be performed.