The fabrication of bioresorbable implants for bone defects replacement using computer tomogram and 3D printing

2017 ◽  
Author(s):  
P. G. Kuznetsov ◽  
S. I. Tverdokhlebov ◽  
S. I. Goreninskii ◽  
E. N. Bolbasov ◽  
A. V. Popkov ◽  
...  
Keyword(s):  
3D Printing ◽  
Bone Defects ◽  
Computer Tomogram ◽  
Bioresorbable Implants

scholarly journals 3D Printing Individualized Assisted Repair and Reconstruction of Irregular Bone Neoplastic Bone Defects: Exploration and Practice in Scapular Aneurysmal Cystic Bone Defects

2021 ◽  
Author(s):  
Guochen Luo ◽  
yao Zhang ◽  
Xiahua Wang ◽  
Shuaishuai Chen ◽  
Dongyi Li ◽  
...  
Keyword(s):  
3D Printing ◽  
Bone Defect ◽  
Bone Tumor ◽  
Surgical Approach ◽  
Treatment Plan ◽  
Operation Time ◽  
Bone Defects ◽  
Anatomical Structure ◽  
Medical Software

Abstract Objective: To explore the clinical efficacy of using 3D printing individualized treatment plan in the auxiliary repair and reconstruction of irregular bone tumor bone defect.Methods：Seven patients with aneurysmal bone cyst of scapula were selected. Based on the CT data of the patient, the scapula (including defect) and pelvis were reconstructed by computer Mimics Medical software. Print out the reconstructed scapula model with a 3D printer. Before operation, the model was used to design the surgical approach and simulate the operation process, to determine the length and Radian of the plate and the number and direction of screws, and to determine the bone mass of the ilium and make reasonable segmentation and distribution. The operation time, the amount of bleeding, the length and Radian of the plate, and the direction and number of screws were recorded.Results : The average follow-up time was 25.6 months, and none of the 7 patients had recurrence during the follow-up period; The surgical approach, the length and Radian of the internal fixation, the number and direction of screws were consistent with the designed operation plan. The anatomical structure of scapula and the function of shoulder joint gradually recovered.Conclusions: Compared with traditional methods, the use of 3D printing technology in the treatment of irregular bone tumor bone defect has less trauma, shorter operation time and less bleeding, which can reduce the waste of bone graft and reconstruct the anatomical structure of bone defect more completely.

scholarly journals Fibrin Glue Implants Seeded with Dental Pulp and Periodontal Ligament Stem Cells for the Repair of Periodontal Bone Defects: A Preclinical Study

2021 ◽  
Vol 8 (6) ◽  
pp. 75
Author(s):  
Natella I. Enukashvily ◽  
Julia A. Dombrovskaya ◽  
Anastasia V. Kotova ◽  
Natalia Semenova ◽  
Irina Karabak ◽  
...  
Keyword(s):  
Stem Cells ◽  
3D Printing ◽  
Fibrin Glue ◽  
Bone Defect ◽  
Dental Pulp ◽  
Alveolar Bone ◽  
Bone Defects ◽  
Osteogenic Potential ◽  
Fibrin Gel ◽  
A Cell

A technology to create a cell-seeded fibrin-based implant matching the size and shape of bone defect is required to create an anatomical implant. The aim of the study was to develop a technology of cell-seeded fibrin gel implant creation that has the same shape and size as the bone defect at the site of implantation. Using computed tomography (CT) images, molds representing bone defects were created by 3D printing. The form was filled with fibrin glue and human dental pulp stem cells (DPSC). The viability, set of surface markers and osteogenic differentiation of DPSC grown in fibrin gel along with the clot retraction time were evaluated. In mice, an alveolar bone defect was created. The defect was filled with fibrin gel seeded with mouse DPSC. After 28 days, the bone repair was analyzed with cone beam CT and by histological examination. The proliferation rate, set of surface antigens and osteogenic potential of cells grown inside the scaffold and in 2D conditions did not differ. In mice, both cell-free and mouse DPSC-seeded implants increased the bone tissue volume and vascularization. In mice with cell-seeded gel implants, the bone remodeling process was more prominent than in animals with a cell-free implant. The technology of 3D-printed forms for molding implants can be used to prepare implants using components that are not suitable for 3D printing.

Application of 3D Printing Technology in Bone Tissue Engineering: A Review

2020 ◽  
Vol 17 ◽  
Author(s):  
Yashan Feng ◽  
Shijie Zhu ◽  
Di Mei ◽  
Jiang Li ◽  
Jiaxiang Zhang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Defects ◽  
3D Bioprinting ◽  
Printing Technology ◽  
Bone Defect Repair ◽  
3D Printing Technology ◽  
Defect Repair

: Clinically, the treatment of bone defects remains a significant challenge, as it requires autogenous bone grafts or bone graft substitutes. However, the existing biomaterials often fail to meet the clinical requirements in terms of structural support, bone induction and controllable biodegradability. In the treatment of bone defects, 3D porous scaffolds have at-tracted much attention in the orthopedic field. In terms of appearance and microstructure, complex bone scaffolds created by 3D printing technology are similar to human bone. On this basis, the combination of active substances including cells and growth factors is more conducive to bone tissue reconstruction, which is of great significance for the personalized treatment of bone defects. With the continuous development of 3D printing technology, it has been widely used in bone defect repair as well as diagnosis and rehabilitation, creating an emerging industry with excellent market potential. Meanwhile, the di-verse combination of 3D printing technology with multi-disciplinary fields such as tissue engineering, digital medicine, and materials science has made 3D printing products with good biocompatibility, excellent osteo-inductive capacity and stable mechanical properties. In the clinical application of the repair of bone defects, various biological materials and 3D printing methods have emerged to make patient-specific bioactive scaffolds. The microstructure of 3D printed scaffolds can meet the complex needs of bone defect repair and support the personalized treatment of patients. Some of the new materials and technologies that emerged from the 3D printing industry's advent in the past decade successfully translated into clinical practice. In this article, we first introduced the development and application of different types of materials that were used in 3D bioprinting, including metal, ceramic materials, polymer materials, composite materials, and cell tissue. The combined application of 3D bioprinting and other manufacturing method used for bone tissue engineering are also discussed in this ar-ticle. Finally, we discussed the bottleneck of 3D bioprinting technique and forecasted its research orientation and prospect.

Novel exploration of 3D printed wrist arthroplasty to solve the severe and complicated bone defect of wrist

2017 ◽  
Vol 23 (3) ◽  
pp. 465-473 ◽  
Author(s):  
Qing Han ◽  
Yanguo Qin ◽  
Yun Zou ◽  
Chenyu Wang ◽  
Haotian Bai ◽  
...  
Keyword(s):  
3D Printing ◽  
Three Dimensional ◽  
Surgical Techniques ◽  
Bone Defects ◽  
Printing Technology ◽  
Content Type ◽  
3D Printing Technology ◽  
3D Printed ◽  
And Function ◽  
Wrist Arthroplasty

Purpose Although proximal row carpectomy, wrist arthrodesis and even total wrist arthroplasty were developed to treat wrist disease using bone and cartilage of the wrist, severe and complicated bone defects caused by ferocious trauma and bone tumors remain a stubborn problem for surgeons. Development and application of the three-dimensional (3D) printing technology may provide possible solutions. Design/methodology/approach Computed tomography (CT) data of three cases with severe bone defects caused by either trauma or bone tumor were collected and converted into three-dimensional models. Prostheses were designed individually according to the residual anatomical structure of the wrist based on the models. Both the models and prostheses were produced using 3D printing technology. A preoperative design was prepared according to the models and prostheses. Then arthroplasty was performed after preoperative simulation with printed models and prostheses. Findings The diameter of the stem and radial medullary cavity, the direction and location of the prosthesis, and other components were checked during the preoperative design and simulation process phases. The three cases with 3D printed wrist all regained reconstruction of normal anatomy and part of the function after surgery. The average increasing Cooney score rate of Cases 2 and 3 was 133.34 ± 23.57 per cent, and that of Case 1 reached 85 per cent. The average declining rate of the Gartland and Werley Score in Cases 2 and 3 was 65.21 ± 18.89 per cent, and that of Case 1 dropped to 5 per cent in the last follow-up. The scores indicated that patients experienced pain relief and function regain. In addition, the degree of patient satisfaction improved. Originality/value 3D printed wrist arthroplasty may provide an effective method for severe and complicated cases without sacrificing other bones. Personal customization can offer better anatomy and function than arthrodesis or other traditional surgical techniques.

Direct 3D printing of a tough hydrogel incorporated with carbon nanotubes for bone regeneration

2019 ◽  
Vol 7 (45) ◽  
pp. 7207-7217 ◽  
Author(s):  
Haomin Cui ◽  
Yaling Yu ◽  
Xiaokeng Li ◽  
Ziyang Sun ◽  
Jihao Ruan ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
3D Printing ◽  
Bone Regeneration ◽  
Three Dimensional ◽  
Bone Defects ◽  
Tissue Scaffolds ◽  
Printing Technique ◽  
Regeneration Of Bone ◽  
3D Printing Technique

The emerging three-dimensional (3D) printing technique has shown prominent advantages to fabricate hydrogel-based tissue scaffolds for the regeneration of bone defects.

scholarly journals 3D Printing: a clinician’s experience

2014 ◽  
Vol 96 (7) ◽  
pp. 230-231 ◽  
Author(s):  
Craig Gerrand
Keyword(s):  
3D Printing ◽  
Surgical Navigation ◽  
Digital Technologies ◽  
Bone Defects ◽  
Bone Tumours ◽  
Additive Layer Manufacturing ◽  
Layer Manufacturing ◽  
Primary Bone ◽  
Primary Bone Tumours

The convergence of digital technologies in imaging, surgical navigation and additive layer manufacturing has opened up new possibilities for surgeons in many fields. One of these is the reconstruction of major bone defects after the resection of primary bone tumours.

scholarly journals The usage of combination of tricalcium phosphate and polylactic acid as materials for 3D printing of alloplastic blocks

2017 ◽  
Vol 8 (3) ◽  
pp. 47-50 ◽  
Author(s):  
Olga O Filatova ◽  
Andrey G Klimov ◽  
Boris V Seleznev
Keyword(s):  
3D Printing ◽  
Polylactic Acid ◽  
Tricalcium Phosphate ◽  
Negative Impact ◽  
Maxillofacial Surgery ◽  
Bone Defects ◽  
Real Patient ◽  
Manufacturing Method ◽  
Tissue Replacement ◽  
Operating Region

This study describes the manufacturing method of alloplastic blocks for treatment of bone defects through tissue replacement with combination of tricalcium phosphate and polylactic acid. The method is unique because for its implementation we used 3d-printing and materials that we had not combined before. Such approach to manufacturing of synthetic blocks allows us to decide several tasks: planning of surgical operation’s strategy by means of modelling in specialized software of certain operating region and to print block with suitable shape and size which would accurately fit the edges of bone defects and fill it. Thus, we can achieve all objectives in the shortest possible time, while saving time and resources. Using this methods, we created experimental model of lower jaw and alloplastic block that can be used with a real patient and be widely applied not only in surgical dentistry and maxillofacial surgery, but also in any other branch of medicine.Combination of tricalcium phosphate and polylactic acid has several advantages because first component acts as a frame and due to its chemical structure makes block’s shape more stable. The second component acts as a filler by means of irregular shape of granules and creates spongiform structure for further blood vessels growth. In addition, materials have properties such as: bioinertness, biocompatibility, biodegradable and don’t have negative impact on the organism. Using this method, we can get the fragment that meets all requirements, and surgical operation becomes economically profitable both for patient and for hospital.

scholarly journals Individualized 3D printing-assisted repair and reconstruction of neoplastic bone defects at irregular bone sites: exploration and practice in the treatment of scapular aneurysmal bone cysts

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Guochen Luo ◽  
Yao Zhang ◽  
Xiahua Wang ◽  
Shuaishuai Chen ◽  
Dongyi Li ◽  
...  
Keyword(s):  
3D Printing ◽  
Surgical Approach ◽  
Bone Structure ◽  
Operation Time ◽  
Bone Defects ◽  
Anatomical Structure ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Medical Software

Abstract Background The irregular anatomical shape and complex structures of irregular bones make it more difficult to repair and reconstruct bone defects in irregular bones than in the long bones of the extremities. Three-dimensional (3D) printing technology can help to overcome the technical limitations of irregular bone repair by generating simulations that enable structural integration of the lesion area and bone structure of the donor site in all directions and at multiple angles. Thus, personalized and accurate treatment plans for restoring anatomical structure, muscle attachment points, and maximal function can be made. The present study aimed to investigate the ability of 3D printing technology to assist in the repair and reconstruction of scapular aneurysmal ABC defects. Methods The study included seven patients with ABCs of the scapula. Based on computed tomography (CT) data for the patient, the scapula (including the defect) and pelvis were reconstructed using Mimics Medical software. The reconstructed scapula model was printed using a 3D printer. Before the operation, the model was used to design the surgical approach and simulate the operation process, to determine the length and radius of the plate and the number and direction of screws, and to determine the bone mass of the ilium and develop reasonable strategies for segmentation and distribution. The operation time, amount of bleeding, length and radius of the plate, and direction and number of screws were recorded. Results The average duration of follow-up was 25.6 months, and none of the seven patients experienced recurrence during the follow-up period. The surgical approach, the length and radius of internal fixation, and the number and direction of screws were consistent with the designed operation plan. Patients gradually recovered the anatomical structure of the scapula and function of the shoulder joint. Conclusions In the treatment of bone defects caused by irregular bone tumors, 3D printing technology combined with surgery has the advantages of less trauma, short operation time, less bleeding and reducing the difficulty of operation, which can reduce the waste of bone graft, and more complete reconstruction of the anatomical structure of the defective bone.

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