Role of activator protein 1, nuclear factor-κB, and nuclear factor of activated T cells in IgE receptor-mediated cytokine expression in mature human mast cells

2003 ◽  
Vol 111 (5) ◽  
pp. 1062-1068 ◽  
Author(s):  
Axel Lorentz ◽  
Ilka Klopp ◽  
Thomas Gebhardt ◽  
Michael P. Manns ◽  
Stephan C. Bischoff
Keyword(s):  
T Cells ◽  
Mast Cells ◽  
Nuclear Factor Κb ◽  
Cytokine Expression ◽  
Nuclear Factor ◽  
Activator Protein 1 ◽  
Ige Receptor ◽  
Activated T Cells ◽  
Human Mast Cells

scholarly journals Human Mast Cells Release Metalloproteinase-9 on Contact with Activated T Cells: Juxtacrine Regulation by TNF-α

2001 ◽  
Vol 167 (7) ◽  
pp. 4008-4016 ◽  
Author(s):  
Dana Baram ◽  
Gayle G. Vaday ◽  
Pazit Salamon ◽  
Ilana Drucker ◽  
Rami Hershkoviz ◽  
...  
Keyword(s):  
T Cells ◽  
Mast Cells ◽  
Activated T Cells ◽  
Human Mast Cells ◽  
Tnf Α ◽  
Metalloproteinase 9

B-cell antigen receptor activates transcription factors NFAT (nuclear factor of activated T-cells) and NF-κB (nuclear factor κB) via a mechanism that involves diacylglycerol

2004 ◽  
Vol 32 (1) ◽  
pp. 113-115 ◽  
Author(s):  
P. Antony ◽  
J.B. Petro ◽  
G. Carlesso ◽  
N.P. Shinners ◽  
J. Lowe ◽  
...  
Keyword(s):  
T Cells ◽  
Transcription Factors ◽  
B Cell ◽  
Antigen Receptor ◽  
Nuclear Factor Κb ◽  
B Cell Antigen Receptor ◽  
Nuclear Factor ◽  
Activated T Cells ◽  
Cell Antigen Receptor ◽  
Cell Antigen

Engagement of the B-cell antigen receptor (BCR) induces the activation of various transcription factors, including NFAT (nuclear factor of activated T-cells) and NF-κB (nuclear factor κB), which participate in long-term biological responses such as proliferation, survival and differentiation of B-lymphocytes. We addressed the biochemical basis of this process using the DT40 chicken B-cell lymphoma. We discovered that Bruton's tyrosine kinase (BTK) and phospholipase C-γ2 (PLC-γ2) are required to activate NFAT and NF-κB, and to produce the lipid second messenger diacylglycerol in response to BCR cross-linking. Therefore the functional integrity of the BTK/PLC-γ2/diacylglycerol signalling axis is crucial for BCR-directed activation of both transcription factors NFAT and NF-κB.

scholarly journals The Essential Role of MEKK3 Signaling in Angiotensin II-induced Calcineurin/Nuclear Factor of Activated T-cells Activation

2005 ◽  
Vol 280 (44) ◽  
pp. 36737-36746 ◽  
Author(s):  
Shahrzad Abbasi ◽  
Bing Su ◽  
Rodney E. Kellems ◽  
JianHua Yang ◽  
Yang Xia
Keyword(s):  
T Cells ◽  
Angiotensin Ii ◽  
Essential Role ◽  
Nuclear Factor ◽  
Activated T Cells
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