Intestinal transformation results in transforming growth factor-beta-dependent alteration in tumor cell-cell matrix interactions

Surgery ◽  
2003 ◽  
Vol 133 (5) ◽  
pp. 568-579 ◽  
Author(s):  
David H. Berger ◽  
Christine A. O'Mahony ◽  
Hongmiao Sheng ◽  
Jinyi Shao ◽  
Daniel Albo ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tumor Cell ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Cell Matrix ◽  
Matrix Interactions ◽  
Growth Factor Beta ◽  
Cell Matrix Interactions ◽  
Cell Cell

P0297 : The transforming growth factor-beta (TGF-β) governs human liver tumor cell plasticity

2015 ◽  
Vol 62 ◽  
pp. S419-S420
Author(s):  
A. Malfettone ◽  
J. Fernando ◽  
P. Koudelkova ◽  
J. Soukupova ◽  
E. Bertran ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tumor Cell ◽  
Liver Tumor ◽  
Transforming Growth Factor Beta ◽  
Human Liver ◽  
Transforming Growth Factor ◽  
Cell Plasticity ◽  
Tumor Cell Plasticity ◽  
Growth Factor Beta ◽  
Liver Tumor Cell

scholarly journals Separation of cell survival, growth, migration, and mesenchymal transdifferentiation effects of fibroblast secretome on tumor cells of head and neck squamous cell carcinoma

Tumor Biology ◽  
2017 ◽  
Vol 39 (11) ◽  
pp. 101042831770550 ◽  
Author(s):  
Veronika Maria Metzler ◽  
Christian Pritz ◽  
Anna Riml ◽  
Angela Romani ◽  
Raphaela Tuertscher ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Growth Factor ◽  
Tumor Cell ◽  
Cell Survival ◽  
Tumor Cells ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Paracrine Factors ◽  
Mesenchymal Transition ◽  
Growth Factor Beta

Fibroblasts play a central role in tumor invasion, recurrence, and metastasis in head and neck squamous cell carcinoma. The aim of this study was to investigate the influence of tumor cell self-produced factors and paracrine fibroblast–secreted factors in comparison to indirect co-culture on cancer cell survival, growth, migration, and epithelial–mesenchymal transition using the cell lines SCC-25 and human gingival fibroblasts. Thereby, we particularly focused on the participation of the fibroblast-secreted transforming growth factor beta-1.Tumor cell self-produced factors were sufficient to ensure tumor cell survival and basic cell growth, but fibroblast-secreted paracrine factors significantly increased cell proliferation, migration, and epithelial–mesenchymal transition–related phenotype changes in tumor cells. Transforming growth factor beta-1 generated individually migrating disseminating tumor cell groups or single cells separated from the tumor cell nest, which were characterized by reduced E-cadherin expression. At the same time, transforming growth factor beta-1 inhibited tumor cell proliferation under serum-starved conditions. Neutralizing transforming growth factor beta antibody reduced the cell migration support of fibroblast-conditioned medium. Transforming growth factor beta-1 as a single factor was sufficient for generation of disseminating tumor cells from epithelial tumor cell nests, while other fibroblast paracrine factors supported tumor nest outgrowth. Different fibroblast-released factors might support tumor cell proliferation and invasion, as two separate effects.

Transforming Growth Factor Beta (TGFβ) Gene Polymorphisms in Different Phenotypes of Sarcoidosis

Pneumologie ◽  
2010 ◽  
Vol 64 (S 03) ◽  
Author(s):  
S Pabst ◽  
T Fränken ◽  
J Schönau ◽  
D Skowasch ◽  
C Grohé
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Gene Polymorphisms ◽  
Transforming Growth Factor ◽  
Growth Factor Beta
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