scholarly journals Improved prospects for food allergy prevention

2017 ◽  
Vol 9 (4) ◽  
pp. 254 ◽  
Author(s):  
Rohan Ameratunga
Keyword(s):  
Food Allergy ◽  
High Risk ◽  
Allergy Prevention ◽  
Window Of Opportunity ◽  
Early Introduction ◽  
The World ◽  
Food Challenges ◽  
High Risk Children

ABSTRACT Three recent publications from Professor Gideon Lack have fundamentally changed our understanding of how to prevent food allergy. His team has shown that early introduction of allergenic foods may prevent food allergy in most but not all high-risk children. Various allergy and paediatric societies around the world are changing their recommendations based on these three studies. It appears there is a window of opportunity to safely introduce allergenic foods to high-risk children. This has resource implications, as some of these children will need testing and food challenges.

scholarly journals Dietary exposures and allergy prevention in high-risk infants

2021 ◽  
Vol 26 (8) ◽  
pp. 504-505
Author(s):  
Elissa M Abrams ◽  
Julia Orkin ◽  
Carl Cummings ◽  
Becky Blair ◽  
Edmond S Chan
Keyword(s):  
Food Allergy ◽  
High Risk ◽  
Food Allergies ◽  
Allergy Prevention ◽  
Severe Reaction ◽  
Omega 3 ◽  
Atopic Condition ◽  
Specific Formula ◽  
High Risk Infants ◽  
Hydrolyzed Formula

Abstract Infants at high risk for developing a food allergy have either an atopic condition (such as eczema) themselves or an immediate family member with such a condition. Breastfeeding should be promoted and supported regardless of issues pertaining to food allergy prevention, but for infants whose mothers cannot or choose not to breastfeed, using a specific formula (i.e., hydrolyzed formula) is not recommended to prevent food allergies. When cow’s milk protein formula has been introduced in an infant’s diet, make sure that regular ingestion (as little as 10 mL daily) is maintained to prevent loss of tolerance. For high-risk infants, there is compelling evidence that introducing allergenic foods early—at around 6 months, but not before 4 months of age—can prevent common food allergies, and allergies to peanut and egg in particular. Once an allergenic food has been introduced, regular ingestion (e.g., a few times a week) is important to maintain tolerance. Common allergenic foods can be introduced without pausing for days between new foods, and the risk for a severe reaction at first exposure in infancy is extremely low. Pre-emptive in-office screening before introducing allergenic foods is not recommended. No recommendations can be made at this time about the role of maternal dietary modification during pregnancy or lactation, or about supplementing with vitamin D, omega 3, or pre- or probiotics as means to prevent food allergy.

Oral food challenges in clinical practice: a missing element of food allergy diagnosis in Russia

2021 ◽  
Vol 17 (4) ◽  
pp. 19-29
Author(s):  
Daria M. Levina ◽  
Ilya A. Korsunskiy ◽  
Daniel B. Munblit
Keyword(s):  
Food Allergy ◽  
Russian Federation ◽  
Food Challenge ◽  
Clinical History ◽  
Allergy Diagnosis ◽  
Laboratory Test Results ◽  
The World ◽  
Life Threatening ◽  
Food Challenges ◽  
Food Allergy Diagnosis

Food allergy is one of the most prevalent allergic conditions, causing reduction in patient quality of life. It is linked with high levels of anxiety due to potential life-threatening reactions, and high economic burden for a healthcare system. Food allergy affects approximately 5 to 10% of children around the world. In Russian Federation the diagnosis of food allergy is primarily based on clinical history, laboratory test results, examination and elimination of suspected food. Meanwhile oral food challenge (OFC) is considered a gold standard of food allergy diagnosis by most of professional bodies nationally and internationally. OFC is a diagnostic procedure involving administration of a causative allergen in gradually increasing amount under a close medical supervision. The method is safe, highly specific and sensitive and is widely used around the world for more than 45 years. The main goals of OFC include food allergy diagnosis and presence of tolerance evaluation, which may result in diet expansion. OFC may also help establishing both, reaction severity and dose needed to elicit reaction, which may further assist with alleviation of patients anxiety. In this paper we discuss existing approaches to the diagnosis of food allergy in Russian Federation and review available recommendations on OFC outlined in international guidelines.

296 Double blind food challenges (FC) in a prospective allergy prevention program for high risk infants

1985 ◽  
Vol 75 (1) ◽  
pp. 178
Author(s):  
M MELLON ◽  
S HELLER ◽  
R OCONNOR ◽  
R HAMBURGER ◽  
R ZEIGER
Keyword(s):  
High Risk ◽  
Prevention Program ◽  
Allergy Prevention ◽  
Double Blind ◽  
Food Challenges ◽  
High Risk Infants

Induction Of Tolerance Through Early Introduction Of Peanut In High-Risk Children, The LEAP Study

2010 ◽  
Vol 125 (2) ◽  
pp. AB22 ◽  
Author(s):  
G. Du Toit ◽  
G. Roberts ◽  
P. Sayre ◽  
V. Turcanu ◽  
H.R. Fisher ◽  
...  
Keyword(s):  
High Risk ◽  
Early Introduction ◽  
Induction Of Tolerance ◽  
High Risk Children

scholarly journals Food allergy: Mechanisms, diagnosis, and management

2021 ◽  
Vol 35 ◽  
pp. 100-104
Author(s):  
Sowmya Arudi Nagarajan ◽  
Harsha Neramballi Subba Rao
Keyword(s):  
Food Allergy ◽  
Health Professionals ◽  
Public Perception ◽  
Early Introduction ◽  
Diagnosis And Management ◽  
True Prevalence ◽  
The Past ◽  
The World ◽  
Developed World ◽  
India And China

Food allergy (FA) is a dynamic field. It is not only evolving but also increasing in the prevalence and incidence all over the world. The term “Food allergy” is often misused, not only by patients, their families but also by health professionals. All adverse food reactions are erroneously labeled as “Food allergy.” This has to be recognized and avoided to make a proper evaluation, diagnosis and management. Surveys have shown that the prevalence of FA based on public perception runs as high as 60%, whereas the true prevalence is around is around 2–8%. FA is more common in early childhood days (6–8%) compared to adults (1–2%). There are several known and unknown reasons for changing picture of FA across the globe. In the developed world, the peanut sensitivity has doubled in prevalence over the past decade. In the developing world (namely, India, and China), the prevalence of Peanut sensitivity/allergy is much less, although the consumption of Peanuts is much higher. Lately, it has also been observed that early introduction of so called “allergenic foods” to infants and children early in life seems to actually reduce the incidence of allergies developing later in childhood.

Which advises for primary food allergy prevention in normal or high-risk infant?

2016 ◽  
Vol 27 (8) ◽  
pp. 774-778 ◽  
Author(s):  
Giampaolo Ricci ◽  
Francesca Cipriani
Keyword(s):  
Food Allergy ◽  
High Risk ◽  
Allergy Prevention ◽  
High Risk Infant

scholarly journals Early Introduction of Foods for Food Allergy Prevention

2014 ◽  
Vol 1 (2) ◽  
pp. 107-116 ◽  
Author(s):  
Jennifer J. Koplin ◽  
Katrina J. Allen
Keyword(s):  
Food Allergy ◽  
Allergy Prevention ◽  
Early Introduction

scholarly journals Introduction of Complementary Foods to Infants

2017 ◽  
Vol 70 (Suppl. 2) ◽  
pp. 47-54 ◽  
Author(s):  
Christina West
Keyword(s):  
Food Allergy ◽  
High Risk ◽  
Infant Feeding ◽  
Allergic Disease ◽  
Peanut Allergy ◽  
Future Research ◽  
Optimal Timing ◽  
Controlled Trials ◽  
Allergy Prevention ◽  
Complementary Foods

While earlier food allergy prevention strategies implemented avoidance of allergenic foods in infancy, the current paradigm is shifting from avoidance to controlled exposure. This review focuses on the outcome of recent randomized controlled trials, which have examined the early introduction of allergenic foods for allergy prevention, and discusses the implementation of results in clinical practice. In infants at high risk of allergic disease, there is now direct evidence that regular early peanut consumption will reduce the prevalence of peanut allergy, compared to avoidance. Many international infant feeding guidelines already recommend complementary foods, including allergenic foods, to be introduced from 4 to 6 months of age irrespective of family history risk. Interim guidelines from 10 International Pediatric Allergy Associations state that healthcare providers should recommend the introduction of peanut-containing products into the diets of infants at high risk of allergic disease in countries where peanut allergy is prevalent. Direct translation of the results obtained from a cohort of high-risk infants to the general population has proved difficult, and issues regarding feasibility, safety, and cost-effectiveness have been raised. Five randomized placebo-controlled trials have assessed the effects of early egg exposure in infancy with varying results. In a recent comprehensive meta-analysis, there was moderate-certainty evidence that early versus late introduction of egg was associated with a reduced egg allergy risk. Although promising, optimal timing, doses, and if the feeding regimen should be stratified according to infant allergy risk remain to be determined. The single study that assessed introduction of multiple foods from 3 months whilst breastfeeding compared with exclusive breastfeeding until 6 months of age showed no reduction in food allergy prevalence. Future research should aim at optimizing infant feeding regimens and support a tolerogenic gastrointestinal microenvironment during the period of food allergen introduction.

The development of allergy in high-risk children

1997 ◽  
Vol 27 (11) ◽  
pp. 1247-1253 ◽  
Author(s):  
M. L. BURR ◽  
T. G. MERRETT ◽  
F. D. J. DUNSTAN ◽  
M. J. MAGUIRE
Keyword(s):  
High Risk ◽  
High Risk Children
Sign in / Sign up

Export Citation Format

Share Document