scholarly journals Patterns of coordinated cortical remodeling during adolescence and their associations with functional specialization and evolutionary expansion

2017 ◽  
Vol 114 (13) ◽  
pp. 3527-3532 ◽  
Author(s):  
Aristeidis Sotiras ◽  
Jon B. Toledo ◽  
Raquel E. Gur ◽  
Ruben C. Gur ◽  
Theodore D. Satterthwaite ◽  
...  
Keyword(s):  
Brain Development ◽  
Large Scale ◽  
Nonnegative Matrix ◽  
Higher Order ◽  
Rapid Expansion ◽  
Small Samples ◽  
Association Cortex ◽  
Functional Specialization ◽  
Normal Brain ◽  
Behavioral Repertoire

During adolescence, the human cortex undergoes substantial remodeling to support a rapid expansion of behavioral repertoire. Accurately quantifying these changes is a prerequisite for understanding normal brain development, as well as the neuropsychiatric disorders that emerge in this vulnerable period. Past accounts have demonstrated substantial regional heterogeneity in patterns of brain development, but frequently have been limited by small samples and analytics that do not evaluate complex multivariate imaging patterns. Capitalizing on recent advances in multivariate analysis methods, we used nonnegative matrix factorization (NMF) to uncover coordinated patterns of cortical development in a sample of 934 youths ages 8–20, who completed structural neuroimaging as part of the Philadelphia Neurodevelopmental Cohort. Patterns of structural covariance (PSCs) derived by NMF were highly reproducible over a range of resolutions, and differed markedly from common gyral-based structural atlases. Moreover, PSCs were largely symmetric and showed correspondence to specific large-scale functional networks. The level of correspondence was ordered according to their functional role and position in the evolutionary hierarchy, being high in lower-order visual and somatomotor networks and diminishing in higher-order association cortex. Furthermore, PSCs showed divergent developmental associations, with PSCs in higher-order association cortex networks showing greater changes with age than primary somatomotor and visual networks. Critically, such developmental changes within PSCs were significantly associated with the degree of evolutionary cortical expansion. Together, our findings delineate a set of structural brain networks that undergo coordinated cortical thinning during adolescence, which is in part governed by evolutionary novelty and functional specialization.

Schizophrenia: A Neuropathological Perspective

1991 ◽  
Vol 158 (1) ◽  
pp. 8-17 ◽  
Author(s):  
G. W. Roberts
Keyword(s):  
Brain Development ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Structural Changes ◽  
Clinical Symptoms ◽  
Association Cortex ◽  
Minor Role ◽  
Normal Brain ◽  
Genetic Mechanisms ◽  
A Minor

It is probable that all schizophrenics have abnormalities in the medial temporal lobe, which differ in degree but not in kind. The structures of the medial temporal lobe are believed to have a crucial role in the integration and processing of the output from the association cortex. Dysfunction of this system could result in the clinical symptoms that form the core of the schizophrenia syndrome. The structural differences appear to fit the profile of a disturbance in the normal pattern of brain development. The asymmetrical patterns of normal brain development explain how such a disturbance simultaneously affecting both hemispheres could, disproportionately, affect the left (dominant) hemisphere. Epidemiological and pathological evidence points to aberrant genetic mechanisms as being the cause of the developmental anomaly in the majority of cases; environmental factors probably play a minor role. Despite the great progress made in solving the enigma of the structural changes in the brains of schizophrenics, the cause(s) of the changes – the aberrant genetic mechanism controlling brain development – may prove difficult to define.

scholarly journals Higher order Hamiltonian Monte Carlo sampling for cosmological large-scale structure analysis

2021 ◽  
Vol 502 (3) ◽  
pp. 3976-3992
Author(s):  
Mónica Hernández-Sánchez ◽  
Francisco-Shu Kitaura ◽  
Metin Ata ◽  
Claudio Dalla Vecchia
Keyword(s):  
Fourth Order ◽  
Large Scale ◽  
Equations Of Motion ◽  
Large Scale Structure ◽  
Real Space ◽  
Higher Order ◽  
Second Order ◽  
Scale Structure ◽  
Integration Schemes ◽  
Reconstruction Methods

ABSTRACT We investigate higher order symplectic integration strategies within Bayesian cosmic density field reconstruction methods. In particular, we study the fourth-order discretization of Hamiltonian equations of motion (EoM). This is achieved by recursively applying the basic second-order leap-frog scheme (considering the single evaluation of the EoM) in a combination of even numbers of forward time integration steps with a single intermediate backward step. This largely reduces the number of evaluations and random gradient computations, as required in the usual second-order case for high-dimensional cases. We restrict this study to the lognormal-Poisson model, applied to a full volume halo catalogue in real space on a cubical mesh of 1250 h−1 Mpc side and 2563 cells. Hence, we neglect selection effects, redshift space distortions, and displacements. We note that those observational and cosmic evolution effects can be accounted for in subsequent Gibbs-sampling steps within the COSMIC BIRTH algorithm. We find that going from the usual second to fourth order in the leap-frog scheme shortens the burn-in phase by a factor of at least ∼30. This implies that 75–90 independent samples are obtained while the fastest second-order method converges. After convergence, the correlation lengths indicate an improvement factor of about 3.0 fewer gradient computations for meshes of 2563 cells. In the considered cosmological scenario, the traditional leap-frog scheme turns out to outperform higher order integration schemes only when considering lower dimensional problems, e.g. meshes with 643 cells. This gain in computational efficiency can help to go towards a full Bayesian analysis of the cosmological large-scale structure for upcoming galaxy surveys.

Modeling and Implementation of Inter-Campuses Equipment Optimized Management Based on WebGIS

2013 ◽  
Vol 680 ◽  
pp. 534-539
Author(s):  
Wei Feng Ma
Keyword(s):  
Information Management ◽  
Spatial Data ◽  
Large Scale ◽  
New Technology ◽  
Rapid Expansion ◽  
Mathematics Model ◽  
Data Mapping ◽  
Geographically Dispersed ◽  
New Research ◽  
Research Challenge

With the rapid expansion of the campus scale and the increasing of the geographically dispersed campus, how to adopt new theory, new method and new technology to realize the equipment optimized assignment and the information management is a new research challenge. It is the key to safeguard the national fund to use reasonably, and to speed up the development of education healthily. Through analyzing the domestic and foreign related research works, the paper proposed that it can take use of the spatial data expression and analysis with Geographic Information System (GIS) to realize the large-scale and inter-campuses equipment optimized assignment and information management. It discussed the mathematics model and the system architecture. Moreover, the paper described the key implementation technology in great detail such as spatial data mapping with MapInfo professional 9 and the development of WebGIS functions with MapXtreme. The results show that the solution is feasible and effective.

scholarly journals W.S. Gosset and Some Neglected Concepts in Experimental Statistics: Guinnessometrics II

2011 ◽  
Vol 6 (2) ◽  
pp. 252-277 ◽  
Author(s):  
Stephen T. Ziliak
Keyword(s):  
Experimental Design ◽  
Sample Size ◽  
Large Scale ◽  
Statistical Significance ◽  
Small Sample ◽  
Small Samples ◽  
Significant Advance ◽  
Economic Approach ◽  
Barley Malt ◽  
Level Of Significance

AbstractStudent's exacting theory of errors, both random and real, marked a significant advance over ambiguous reports of plant life and fermentation asserted by chemists from Priestley and Lavoisier down to Pasteur and Johannsen, working at the Carlsberg Laboratory. One reason seems to be that William Sealy Gosset (1876–1937) aka “Student” – he of Student'st-table and test of statistical significance – rejected artificial rules about sample size, experimental design, and the level of significance, and took instead an economic approach to the logic of decisions made under uncertainty. In his job as Apprentice Brewer, Head Experimental Brewer, and finally Head Brewer of Guinness, Student produced small samples of experimental barley, malt, and hops, seeking guidance for industrial quality control and maximum expected profit at the large scale brewery. In the process Student invented or inspired half of modern statistics. This article draws on original archival evidence, shedding light on several core yet neglected aspects of Student's methods, that is, Guinnessometrics, not discussed by Ronald A. Fisher (1890–1962). The focus is on Student's small sample, economic approach to real error minimization, particularly in field and laboratory experiments he conducted on barley and malt, 1904 to 1937. Balanced designs of experiments, he found, are more efficient than random and have higher power to detect large and real treatment differences in a series of repeated and independent experiments. Student's world-class achievement poses a challenge to every science. Should statistical methods – such as the choice of sample size, experimental design, and level of significance – follow the purpose of the experiment, rather than the other way around? (JEL classification codes: C10, C90, C93, L66)

scholarly journals The diffusion tensor imaging (DTI) component of the NIH MRI study of normal brain development (PedsDTI)

NeuroImage ◽  
2016 ◽  
Vol 124 ◽  
pp. 1125-1130 ◽  
Author(s):  
Lindsay Walker ◽  
Lin-Ching Chang ◽  
Amritha Nayak ◽  
M. Okan Irfanoglu ◽  
Kelly N. Botteron ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Brain Development ◽  
Diffusion Tensor ◽  
Normal Brain ◽  
Mri Study ◽  
Normal Brain Development ◽  
Diffusion Tensor Imaging Dti

Efficient and High-Quality Seeded Graph Matching: Employing Higher-order Structural Information

2021 ◽  
Vol 15 (3) ◽  
pp. 1-31
Author(s):  
Haida Zhang ◽  
Zengfeng Huang ◽  
Xuemin Lin ◽  
Zhe Lin ◽  
Wenjie Zhang ◽  
...  
Keyword(s):  
Large Scale ◽  
Graph Matching ◽  
Structural Information ◽  
Experimental Studies ◽  
Higher Order ◽  
Personalized Pagerank ◽  
Matching Accuracy ◽  
Approximation Techniques ◽  
Order Of Magnitude ◽  
Matching Score

Driven by many real applications, we study the problem of seeded graph matching. Given two graphs and , and a small set of pre-matched node pairs where and , the problem is to identify a matching between and growing from , such that each pair in the matching corresponds to the same underlying entity. Recent studies on efficient and effective seeded graph matching have drawn a great deal of attention and many popular methods are largely based on exploring the similarity between local structures to identify matching pairs. While these recent techniques work provably well on random graphs, their accuracy is low over many real networks. In this work, we propose to utilize higher-order neighboring information to improve the matching accuracy and efficiency. As a result, a new framework of seeded graph matching is proposed, which employs Personalized PageRank (PPR) to quantify the matching score of each node pair. To further boost the matching accuracy, we propose a novel postponing strategy, which postpones the selection of pairs that have competitors with similar matching scores. We show that the postpone strategy indeed significantly improves the matching accuracy. To improve the scalability of matching large graphs, we also propose efficient approximation techniques based on algorithms for computing PPR heavy hitters. Our comprehensive experimental studies on large-scale real datasets demonstrate that, compared with state-of-the-art approaches, our framework not only increases the precision and recall both by a significant margin but also achieves speed-up up to more than one order of magnitude.

scholarly journals Coxsackievirus B3 infection affects neurogenesis and hinders normal brain development

2008 ◽  
Vol 2 (Suppl 1) ◽  
pp. P61
Author(s):  
Chelsea M Ruller ◽  
Jenna M Tabor-Godwin ◽  
Scott Robinson ◽  
Naili An ◽  
J Lindsay Whitton ◽  
...  
Keyword(s):  
Brain Development ◽  
Coxsackievirus B3 ◽  
Normal Brain ◽  
Normal Brain Development
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