scholarly journals Reconstitution of functional interleukin 2 receptor complexes on fibroblastoid cells: involvement of the cytoplasmic domain of the gamma chain in two distinct signaling pathways.

1993 ◽  
Vol 90 (9) ◽  
pp. 4127-4131 ◽  
Author(s):  
H. Asao ◽  
T. Takeshita ◽  
N. Ishii ◽  
S. Kumaki ◽  
M. Nakamura ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Interleukin 2 ◽  
Cytoplasmic Domain ◽  
Gamma Chain ◽  
Receptor Complexes ◽  
Interleukin 2 Receptor

scholarly journals Solution assembly of the pseudo-high affinity and intermediate affinity interleukin-2 receptor complexes

2008 ◽  
Vol 8 (3) ◽  
pp. 482-489 ◽  
Author(s):  
Zining Wu ◽  
Byron Goldstein ◽  
Thomas M. Laue ◽  
Stefano F. Liparoto ◽  
Michael J. Nemeth ◽  
...  
Keyword(s):  
Interleukin 2 ◽  
Receptor Complexes ◽  
High Affinity ◽  
Interleukin 2 Receptor

scholarly journals An interleukin-2 receptor gamma chain mutation with normal thymus morphology.

1997 ◽  
Vol 100 (12) ◽  
pp. 3036-3043 ◽  
Author(s):  
N Sharfe ◽  
M Shahar ◽  
C M Roifman
Keyword(s):  
Interleukin 2 ◽  
Gamma Chain ◽  
Interleukin 2 Receptor

Kinetic study of interleukin-2 binding on the reconstituted interleukin-2 receptor complexes including the human γ chain

1993 ◽  
Vol 23 (10) ◽  
pp. 2472-2476 ◽  
Author(s):  
Mitsuo Matsuoka ◽  
Toshikazu Takeshita ◽  
Naoto Ishii ◽  
Masataka Nakamura ◽  
Takao Ohkubo ◽  
...  
Keyword(s):  
Kinetic Study ◽  
Interleukin 2 ◽  
Receptor Complexes ◽  
Interleukin 2 Receptor

scholarly journals Expression of the interleukin-2 receptor gamma chain on cord blood mononuclear cells

Blood ◽  
1996 ◽  
Vol 87 (8) ◽  
pp. 3344-3350 ◽  
Author(s):  
S Saito ◽  
T Morii ◽  
H Umekage ◽  
K Makita ◽  
K Nishikawa ◽  
...  
Keyword(s):  
T Cells ◽  
Cord Blood ◽  
Nk Cells ◽  
Mononuclear Cells ◽  
Interleukin 2 ◽  
Gamma Chain ◽  
Blood Lymphocytes ◽  
Interleukin 2 Receptor ◽  
Significant Difference ◽  
Cord Blood Lymphocytes

Lymphocytes in umbilical cord blood and neonatal peripheral blood have been shown to have less ability in an immune reaction. In our present experimental approach to address this issue, we made use of the cord blood of full-term birth infants to investigate the expression of the interleukin- 2 receptor gamma (IL-2Rgamma) chain that is shared with receptors for IL-4, IL-7, IL-9, and IL-15 as well as IL-2. The gamma chain expression in cord blood lymphocytes was about one-third that in the lymphocytes of adults, whereas no significant difference between cord blood and adult monocytes was observed. A reduced expression of the gamma chain was observed in all of the CD4+ T cells, CD8+ T cells, gamma-delta T cells, B cells, CD16+ natural killer (NK) cells, and CD56(bright) NK cells of the cord blood lymphocytes. The reduced gamma chain expression reached two-thirds of that in adults after 3 days of culture in vitro and in infants 3 days after birth, thus implying that the increase in the gamma chain may significantly contribute to the prevention of neonatal infection.

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