scholarly journals Alternately Spliced NH2-terminal Immunoglobulin-like Loop I in the Ectodomain of the Fibroblast Growth Factor (FGF) Receptor 1 Lowers Affinity for both Heparin and FGF-1

1995 ◽  
Vol 270 (17) ◽  
pp. 10231-10235 ◽  
Author(s):  
Fen Wang ◽  
Mikio Kan ◽  
Guochen Yan ◽  
Jianming Xu ◽  
Wallace L. McKeehan
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Fgf Receptor

scholarly journals Differential Regulation of Fibroblast Growth Factor (FGF) Receptor-1 mRNA and Protein by Two Molecular Forms of Basic FGF

1996 ◽  
Vol 271 (10) ◽  
pp. 5663-5670 ◽  
Author(s):  
Agnes Estival ◽  
Veronique Monzat ◽  
Karine Miquel ◽  
François Gaubert ◽  
Etienne Hollande ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Differential Regulation ◽  
Molecular Forms ◽  
Fibroblast Growth ◽  
Fgf Receptor ◽  
Basic Fgf

Fibroblast growth factor-2 stimulates phospholipase Cβ in adult cardiomyocytes

1999 ◽  
Vol 77 (6) ◽  
pp. 569-575 ◽  
Author(s):  
Paramjit S Tappia ◽  
Raymond R Padua ◽  
Vincenzo Panagia ◽  
Elissavet Kardami
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Isolated Heart ◽  
Second Messengers ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Fgf Receptor ◽  
Hypertrophic Response ◽  
Adult Cardiomyocytes ◽  
G Protein Coupled

Although fibroblast growth factor-2 (FGF-2) plays an important role in cardioprotection and growth, little is known about the signals triggered by it in the adult heart. We therefore examined FGF-2-induced effects on phosphoinositide-specific phospholipase C (PI-PLC) isozymes, which produce second messengers linked to the inotropic and hypertrophic response of the myocardium. FGF-2, administered by retrograde perfusion to the isolated heart, induced an increase in inositol-1,4,5-trisphosphate levels in the cytosol, as well as an increase in total PI-PLC activity associated with sarcolemmal and cytosolic fractions. Furthermore FGF-2 induced a time-dependent elevation in cardiomyocyte membrane-associated PLC gamma1 and PLC β1 activities, assayed in immunoprecipitated fractions, and moreover, increased the membrane levels of PLC β1 and PLC β3. Activation of PLC β is suggestive of FGF-2-induced cross-talk between FGF-receptor tyrosine kinase and G-protein-coupled signaling in adult cardiomyocytes and underscores the importance of FGF-2 in cardiac physiology.Key words: FGF-2, signal transduction, PLC gamma, PLC β, cardiomyocytes.

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