scholarly journals Molecular Cloning and Characterization of a Novel Retinoic Acid-inducible Gene That Encodes a Putative G Protein-coupled Receptor

1998 ◽  
Vol 273 (52) ◽  
pp. 35008-35015 ◽  
Author(s):  
Yijun Cheng ◽  
Reuben Lotan
Keyword(s):  
Retinoic Acid ◽  
Molecular Cloning ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled ◽  
Inducible Gene

Molecular Cloning and Characterization of Two Novel Retinoic Acid-Inducible Orphan G-Protein-Coupled Receptors (GPRC5B and GPRC5C)

Genomics ◽  
2000 ◽  
Vol 67 (1) ◽  
pp. 8-18 ◽  
Author(s):  
M.J. Robbins ◽  
D. Michalovich ◽  
J. Hill ◽  
A.R. Calver ◽  
A.D. Medhurst ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Molecular Cloning ◽  
G Protein ◽  
G Protein Coupled Receptors ◽  
G Protein Coupled

Characterization of the murine orphan G-protein-coupled receptor gene Rai3 and its regulation by retinoic acid

Genomics ◽  
2004 ◽  
Vol 83 (2) ◽  
pp. 270-280 ◽  
Author(s):  
Qingguo Tao ◽  
Yijun Cheng ◽  
John Clifford ◽  
Reuben Lotan
Keyword(s):  
Retinoic Acid ◽  
G Protein ◽  
Receptor Gene ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Molecular Cloning and Characterization of a Novel Human G-protein-coupled Receptor, EDG7, for Lysophosphatidic Acid

1999 ◽  
Vol 274 (39) ◽  
pp. 27776-27785 ◽  
Author(s):  
Koji Bandoh ◽  
Junken Aoki ◽  
Hiroyuki Hosono ◽  
Susumu Kobayashi ◽  
Tetsuyuki Kobayashi ◽  
...  
Keyword(s):  
Molecular Cloning ◽  
G Protein ◽  
Lysophosphatidic Acid ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5.

1994 ◽  
Vol 269 (2) ◽  
pp. 1099-1105 ◽  
Author(s):  
P. Kunapuli ◽  
J.J. Onorato ◽  
M.M. Hosey ◽  
J.L. Benovic
Keyword(s):  
G Protein ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
Purification And Characterization ◽  
G Protein Coupled

scholarly journals Characterization of Two Fly LGR (Leucine-Rich Repeat-Containing, G Protein-Coupled Receptor) Proteins Homologous to Vertebrate Glycoprotein Hormone Receptors: Constitutive Activation of Wild-Type Fly LGR1 But Not LGR2 in Transfected Mammalian Cells**This study was supported by NIH Grant HD-23273. The GenBank submission number for fly LGR2 is AF274591.

Endocrinology ◽  
2000 ◽  
Vol 141 (11) ◽  
pp. 4081-4090 ◽  
Author(s):  
Shinya Nishi ◽  
Sheau Yu Hsu ◽  
Karen Zell ◽  
Aaron J. W. Hsueh
Keyword(s):  
G Protein ◽  
Hormone Receptors ◽  
Coupling Mechanism ◽  
Leucine Rich Repeat ◽  
G Protein Coupled Receptor ◽  
Glycoprotein Hormone ◽  
Glycoprotein Hormone Receptors ◽  
Signaling Mechanisms ◽  
G Protein Coupled

Abstract The receptors for lutropin (LH), FSH, and TSH belong to the large G protein-coupled receptor (GPCR) superfamily and are unique in having a large N-terminal extracellular (ecto-) domain important for interactions with the large glycoprotein hormone ligands. Recent studies indicated the evolution of a large family of the leucine-rich repeat-containing, G protein-coupled receptors (LGRs) with at least seven members in mammals. Based on the sequences of mammalian glycoprotein hormone receptors, we have identified a new LGR in Drosophila melanogaster and named it as fly LGR2 to distinguish it from the previously reported fly LH/FSH/TSH receptor (renamed as fly LGR1). Genomic analysis indicated the presence of 10 exons in fly LGR2 as compared with 16 exons in fly LGR1. The deduced fly LGR2 complementary DNA (cDNA) showed 43 and 64% similarity to the fly LGR1 in the ectodomain and transmembrane region, respectively. Comparison of 12 LGRs from diverse species indicated that these proteins can be divided into three subfamilies and fly LGR1 and LGR2 belong to different subfamilies. Potential signaling mechanisms were tested in human 293T cells overexpressing the fly receptors. Of interest, fly LGR1, but not LGR2, showed constitutive activity as reflected by elevated basal cAMP production in transfected cells. The basal activity of fly LGR1 was further augmented following point mutations of key residues in the intracellular loop 3 or transmembrane VI, similar to those found in patients with familial male precocious puberty. The present study reports the cloning of fly LGR2 and indicates that the G protein-coupling mechanism is conserved in fly LGR1 as compared with the mammalian glycoprotein hormone receptors. The characterization of fly receptors with features similar to mammalian glycoprotein hormone receptors allows a better understanding of the evolution of this unique group of GPCRs and future elucidation of their ligand signaling mechanisms.

scholarly journals Identification and characterization of a G protein-coupled receptor homolog encoded by murine cytomegalovirus.

1997 ◽  
Vol 71 (2) ◽  
pp. 1521-1529 ◽  
Author(s):  
N J Davis-Poynter ◽  
D M Lynch ◽  
H Vally ◽  
G R Shellam ◽  
W D Rawlinson ◽  
...  
Keyword(s):  
G Protein ◽  
Murine Cytomegalovirus ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled ◽  
Identification And Characterization

Characterization of a G Protein-Coupled Receptor for Nicotinic Acid

2001 ◽  
Vol 59 (2) ◽  
pp. 349-357 ◽  
Author(s):  
Anna Lorenzen ◽  
Christina Stannek ◽  
Heidrun Lang ◽  
Viktor Andrianov ◽  
Ivars Kalvinsh ◽  
...  
Keyword(s):  
Nicotinic Acid ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled
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