scholarly journals Suppressor of Cytokine Signaling 1 Interacts with the Macrophage Colony-stimulating Factor Receptor and Negatively Regulates Its Proliferation Signal

2001 ◽  
Vol 276 (25) ◽  
pp. 22133-22139 ◽  
Author(s):  
Roland P. Bourette ◽  
Paulo De Sepulveda ◽  
Sylvie Arnaud ◽  
Patrice Dubreuil ◽  
Robert Rottapel ◽  
...  
Keyword(s):  
Cytokine Signaling ◽  
Colony Stimulating Factor ◽  
Suppressor Of Cytokine Signaling ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor

scholarly journals Altered compensatory cytokine signaling underlies the discrepancy between Flt3–/– and Flt3l–/– mice

2018 ◽  
Vol 215 (5) ◽  
pp. 1417-1435 ◽  
Author(s):  
Vivek Durai ◽  
Prachi Bagadia ◽  
Carlos G. Briseño ◽  
Derek J. Theisen ◽  
Arifumi Iwata ◽  
...  
Keyword(s):  
Stem Cell ◽  
Dendritic Cell ◽  
Stem Cell Factor ◽  
Cytokine Signaling ◽  
Colony Stimulating Factor ◽  
Increased Sensitivity ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor

The receptor Flt3 and its ligand Flt3L are both critical for dendritic cell (DC) development, but DC deficiency is more severe in Flt3l−/− mice than in Flt3−/− mice. This has led to speculation that Flt3L binds to another receptor that also supports DC development. However, we found that Flt3L administration does not generate DCs in Flt3−/− mice, arguing against a second receptor. Instead, Flt3−/− DC progenitors matured in response to macrophage colony–stimulating factor (M-CSF) or stem cell factor, and deletion of Csf1r in Flt3−/− mice further reduced DC development, indicating that these cytokines could compensate for Flt3. Surprisingly, Flt3−/− DC progenitors displayed enhanced M-CSF signaling, suggesting that loss of Flt3 increased responsiveness to other cytokines. In agreement, deletion of Flt3 in Flt3l−/− mice paradoxically rescued their severe DC deficiency. Thus, multiple cytokines can support DC development, and the discrepancy between Flt3−/− and Flt3l−/− mice results from the increased sensitivity of Flt3−/− progenitors to these cytokines.

Interleukin-34 and macrophage-colony stimulating factor interact to form a heteromeric and functional cytokine

2014 ◽  
Author(s):  
Aude Segaliny ◽  
Regis Brion ◽  
Benedicte Brulin ◽  
Stephane Teletchea ◽  
Julien Jardin ◽  
...  
Keyword(s):  
Colony Stimulating Factor ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor
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