scholarly journals Stabilization of RNT-1 Protein, Runt-related Transcription Factor (RUNX) Protein Homolog ofCaenorhabditis elegans, by Oxidative Stress through Mitogen-activated Protein Kinase Pathway

2012 ◽  
Vol 287 (13) ◽  
pp. 10444-10452 ◽  
Author(s):  
Kiho Lee ◽  
Jiwon Shim ◽  
Jaebum Bae ◽  
Young-Joon Kim ◽  
Junho Lee
Keyword(s):  
Oxidative Stress ◽  
Transcription Factor ◽  
Protein Kinase ◽  
Mitogen Activated Protein Kinase ◽  
Runx Protein ◽  
Mitogen Activated Protein ◽  
Related Transcription Factor ◽  
Kinase Pathway

The estrogen receptor: more than the average transcription factor

2002 ◽  
Vol 80 (3) ◽  
pp. 335-341 ◽  
Author(s):  
Laura L Hart ◽  
James R Davie
Keyword(s):  
Estrogen Receptor ◽  
Transcription Factor ◽  
Protein Kinase ◽  
Transcriptional Activation ◽  
Mitogen Activated Protein Kinase ◽  
Receptor Mrna ◽  
Estrogen Receptor Mrna ◽  
Mitogen Activated Protein ◽  
Human Estrogen Receptor ◽  
Kinase Pathway

The human estrogen receptor is a steroid nuclear receptor found in breast cancer and a variety of other tissues. Located in the nucleus, it can exist either loosely or tightly associated with the nuclear matrix depending on whether or not it is bound to ligand. When bound to ligand, it is responsible for the transcriptional regulation of estrogen-responsive genes through recruitment of coactivators and corepressors of transcription. The estrogen receptor is also capable of ligand-independent transcriptional activation via the mitogen-activated protein kinase pathway. Ligands have been implicated in the regulation of estrogen receptor levels via changing the levels and stability of estrogen receptor mRNA and protein. The resulting levels of estrogen receptor and the type of ligand bound to it have a direct impact on the transcription of estrogen-responsive genes.Key words: estrogen receptor, transcription factor, mitogen-activated protein kinase, MAPK, estrogen-responsive genes.

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