scholarly journals Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex

2017 ◽  
Vol 292 (37) ◽  
pp. 15378-15394 ◽  
Author(s):  
Naoki Okamoto ◽  
Keisuke Mizote ◽  
Hiroe Honda ◽  
Akinori Saeki ◽  
Yasuharu Watanabe ◽  
...  
Keyword(s):  
Immune Responses ◽  
Innate Immune ◽  
Myeloid Differentiation ◽  
Innate Immune Responses ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Differentiation Factor ◽  
Myeloid Differentiation Factor

scholarly journals Toll-like Receptors Induce a Phagocytic Gene Program through p38

2003 ◽  
Vol 199 (1) ◽  
pp. 81-90 ◽  
Author(s):  
Sean E. Doyle ◽  
Ryan M. O'Connell ◽  
Gustavo A. Miranda ◽  
Sagar A. Vaidya ◽  
Edward K. Chow ◽  
...  
Keyword(s):  
Immune Responses ◽  
Interleukin 1 ◽  
Innate Immune ◽  
Myeloid Differentiation ◽  
Innate Immune Responses ◽  
Toll Like Receptor ◽  
Evolutionarily Conserved ◽  
Myeloid Differentiation Factor ◽  
The Relationship ◽  
Number Of Bacteria

Toll-like receptor (TLR) signaling and phagocytosis are hallmarks of macrophage-mediated innate immune responses to bacterial infection. However, the relationship between these two processes is not well established. Our data indicate that TLR ligands specifically promote bacterial phagocytosis, in both murine and human cells, through induction of a phagocytic gene program. Importantly, TLR-induced phagocytosis of bacteria was found to be reliant on myeloid differentiation factor 88–dependent signaling through interleukin-1 receptor–associated kinase-4 and p38 leading to the up-regulation of scavenger receptors. Interestingly, individual TLRs promote phagocytosis to varying degrees with TLR9 being the strongest and TLR3 being the weakest inducer of this process. We also demonstrate that TLR ligands not only amplify the percentage of phagocytes uptaking Escherichia coli, but also increase the number of bacteria phagocytosed by individual macrophages. Taken together, our data describe an evolutionarily conserved mechanism by which TLRs can specifically promote phagocytic clearance of bacteria during infection.

scholarly journals Toll-Like Receptor 4 Mediates Innate Immune Responses to Haemophilus influenzae Infection in Mouse Lung

2002 ◽  
Vol 168 (2) ◽  
pp. 810-815 ◽  
Author(s):  
Xiaorong Wang ◽  
Christian Moser ◽  
Jean-Pierre Louboutin ◽  
Elena S. Lysenko ◽  
Daniel J. Weiner ◽  
...  
Keyword(s):  
Immune Responses ◽  
Haemophilus Influenzae ◽  
Innate Immune ◽  
Mouse Lung ◽  
Innate Immune Responses ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4

194 A Non-Gluten Component of Wheat is a Strong Stimulator of Innate Immune Responses In Vitro and In Vivo and Acts via Toll Like Receptor 4

2010 ◽  
Vol 138 (5) ◽  
pp. S-36
Author(s):  
Yvonne Junker ◽  
Donatella Barisani ◽  
Daniel A. Leffler ◽  
Towia Libermann ◽  
Simon T. Dillon ◽  
...  
Keyword(s):  
Immune Responses ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4
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