scholarly journals Androgen Receptor Gene Knockout Male Mice Exhibit Impaired Cardiac Growth and Exacerbation of Angiotensin II-induced Cardiac Fibrosis

2005 ◽  
Vol 280 (33) ◽  
pp. 29661-29666 ◽  
Author(s):  
Yasumasa Ikeda ◽  
Ken-ichi Aihara ◽  
Takashi Sato ◽  
Masashi Akaike ◽  
Masanori Yoshizumi ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Angiotensin Ii ◽  
Cardiac Fibrosis ◽  
Gene Knockout ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Male Mice ◽  
Cardiac Growth

scholarly journals Osteoblast Deletion of Exon 3 of the Androgen Receptor Gene Results in Trabecular Bone Loss in Adult Male Mice

2006 ◽  
Vol 22 (3) ◽  
pp. 347-356 ◽  
Author(s):  
Amanda J Notini ◽  
Julie F McManus ◽  
Alison Moore ◽  
Mary Bouxsein ◽  
Mark Jimenez ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Bone Loss ◽  
Trabecular Bone ◽  
Adult Male ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Male Mice ◽  
Trabecular Bone Loss

A floxed allele of the androgen receptor gene causes hyperandrogenization in male mice

2008 ◽  
Vol 33 (1) ◽  
pp. 133-137 ◽  
Author(s):  
Helen E. MacLean ◽  
W. S. Maria Chiu ◽  
Cathy Ma ◽  
Julie F. McManus ◽  
Rachel A. Davey ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Receptor Gene ◽  
Serum Testosterone ◽  
Levator Ani ◽  
Androgen Receptor Gene ◽  
Levator Ani Muscle ◽  
Mrna Levels ◽  
Male Mice ◽  
Androgen Action ◽  
Floxed Allele

We previously generated a conditional floxed mouse line to study androgen action, in which exon 3 of the androgen receptor ( AR) gene is flanked by loxP sites, with the neomycin resistance gene present in intron 3. Deletion of exon 3 in global AR knockout mice causes androgen insensitivity syndrome, characterized by genotypic males lacking normal masculinization. We now report that male mice carrying the floxed allele (ARlox) have the reverse phenotype, termed hyperandrogenization. ARlox mice have increased mass of androgen-dependent tissues, including kidney, ( P < 0.001), seminal vesicle ( P < 0.001), levator ani muscle ( P = 0.001), and heart ( P < 0.05). Serum testosterone is not significantly different. Testis mass is normal, histology shows normal spermatogenesis, and ARlox males are fertile. ARlox males also have normal AR mRNA levels in kidney, brain, levator ani, liver, and testis. This study reaffirms the need to investigate the potential phenotypic effects of floxed alleles in the absence of cre in tissue-specific knockout studies. In addition, this androgen hypersensitivity model may be useful to further investigate the effects of subtle perturbations of androgen action in a range of androgen-responsive systems in the male.

417: The Human Androgen Receptor Gene is a Primary Target of the WNT Signaling Pathway

2006 ◽  
Vol 175 (4S) ◽  
pp. 136-136
Author(s):  
Ralph Buttyan ◽  
Xuezhen Yang ◽  
Min-Wei Chen ◽  
Debra L. Bemis ◽  
Mitchell C. Benson ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Receptor Gene ◽  
Wnt Signaling Pathway ◽  
Androgen Receptor Gene ◽  
Primary Target ◽  
Human Androgen Receptor Gene ◽  
Human Androgen Receptor

Father absence, age at menarche, and sexual behaviors in women: Evaluating the genetic confounding hypothesis using the androgen receptor gene.

2019 ◽  
Vol 13 (3) ◽  
pp. 205-222 ◽  
Author(s):  
Gabriel L. Schlomer ◽  
Jessica Murray ◽  
Brianna Yates ◽  
Kerry Hair ◽  
David J. Vandenbergh
Keyword(s):  
Androgen Receptor ◽  
Sexual Behaviors ◽  
Receptor Gene ◽  
Father Absence ◽  
Androgen Receptor Gene ◽  
Age At Menarche

scholarly journals A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat.

1990 ◽  
Vol 265 (15) ◽  
pp. 8893-8900 ◽  
Author(s):  
W G Yarbrough ◽  
V E Quarmby ◽  
J A Simental ◽  
D R Joseph ◽  
M Sar ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Single Base ◽  
Androgen Insensitivity

The CAG Repeat Within the Androgen Receptor Gene and Benign Prostatic Hyperplasia

1999 ◽  
Vol 162 (1) ◽  
pp. 269-270
Author(s):  
E. Giovannucci ◽  
E.A. Platz ◽  
M.J. Stampfer ◽  
A. Chan ◽  
K. Krithivas ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Benign Prostatic Hyperplasia ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Prostatic Hyperplasia ◽  
Cag Repeat

scholarly journals Chromosome X aneusomy and androgen receptor gene copy number aberrations in apocrine carcinoma of the breast

2021 ◽  
Author(s):  
Anna Cremonini ◽  
Luca Saragoni ◽  
Luca Morandi ◽  
Angelo G. Corradini ◽  
Caterina Ravaioli ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Receptor Gene ◽  
Gene Copy Number ◽  
Androgen Receptor Gene ◽  
Gene Copy ◽  
Immunohistochemical Expression ◽  
Neoplastic Cells ◽  
Genetic Changes ◽  
Rare Tumours ◽  
Regulator Genes

AbstractCarcinomas with apocrine differentiation (CAD) of the breast are rare tumours typically presenting high immunohistochemical expression of androgen receptor (AR) which is a target molecule for personalised therapy. To date, no studies have evaluated the genetic changes that are associated with AR immunohistochemical expression in CADs. The present work aims to characterise AR status in CADs. Twenty CAD tumours were studied with immunohistochemistry, in situ fluorescence hybridization and DNA methylation analysis, to evaluate AR expression and its regulator status. All tumours demonstrated high AR immunohistochemical expression, with over 95% of the neoplastic cells showing AR positivity in 19/20 cases. CADs showed AR gene copy loss in a percentage of neoplastic cells ranging from 5 to 84% (mean 48.93%). AR regulator genes, including the MAGE family, UXT and FLNA, presented variable methylation levels, but were mainly hypomethylated and therefore all transcriptionally active. The results of this study indicate that CADs present AR monosomy, paralleled by higher transcriptional activity of the gene with potential to influence response to AR deprivation therapy.

Analysis of the CAG tract length in the Androgen Receptor gene in Mexican patients with nonsyndromic cryptorchidism

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Daniel A. Landero-Huerta ◽  
Rosa M. Vigueras-Villaseñor ◽  
Lucía Taja-Chayeb ◽  
Fabiola García-Andrade ◽  
Elena Aréchaga-Ocampo ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Germ Cell ◽  
Receptor Gene ◽  
Germ Cell Tumors ◽  
Androgen Receptor Gene ◽  
Testicular Descent ◽  
Healthy Individuals ◽  
Testicular Germ Cell ◽  
Molecular Alteration ◽  
Mexican Patients

Abstract Objectives Cryptorchidism is the most common genitourinary birth defect in live newborn males and is considered as an important risk factor for testicular germ cell tumors and infertility. The Androgen Receptor gene is important in this pathology due to its participation, mainly, in the inguinoscrotal phase of testicular descent. We determine the length of the CAG tract in the Androgen Receptor (AR) gene in Mexican patients with nonsyndromic cryptorchidism. Methods One hundred and 15 males were included; of these, 62 had nonsyndromic cryptorchidism and 53 were healthy volunteers. DNA was extracted from a peripheral blood samples, subsequently, the CAG tract in exon 1 of AR gene was amplified by PCR and sequenced. Results Mexican patients with nonsyndromic cryptorchidism presented 25.03 ± 2.58 repeats of CAG tract in the AR gene compared to 22.72 ± 3.17 repeats of CAG tract in Mexican healthy individuals (p≤0.0001; t value of 4.3). Furthermore, the deletion of codon 57 that corresponds to the deletion of a leucine residue at position 57 (Del L57) in the AR gene was found for the first time in a nonsyndromic cryptorchidism patient. This molecular alteration has been related previously to testicular germ cell tumor (TGCT). Conclusions The CAG tract in the AR gene is longer in patients with nonsyndromic cryptorchidism than in healthy individuals, supporting the association between this polymorphism of the AR gene and nonsyndromic cryptorchidism in the Mexican population.

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