scholarly journals Catalase Takes Part in Rat Liver Mitochondria Oxidative Stress Defense

2007 ◽  
Vol 282 (33) ◽  
pp. 24407-24415 ◽  
Author(s):  
Mauro Salvi ◽  
Valentina Battaglia ◽  
Anna Maria Brunati ◽  
Nicoletta La Rocca ◽  
Elena Tibaldi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Liver ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Oxidative Stress Defense ◽  
Stress Defense

Nitric oxide produced in rat liver mitochondria causes oxidative stress and impairment of respiration after transient hypoxia

2003 ◽  
Vol 17 (15) ◽  
pp. 2194-2201 ◽  
Author(s):  
Lorenz Schild ◽  
Thomas Reinheckel ◽  
Michael Reiser ◽  
Thomas F. W. Horn ◽  
Gerald Wolf ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Rat Liver ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria

Effect of graded corticosterone treatment on aging-related markers of oxidative stress in rat liver mitochondria

2006 ◽  
Vol 8 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Pilar Caro ◽  
José Gómez ◽  
Alberto Sanz ◽  
Manel Portero-Otín ◽  
Reinald Pamplona ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Liver ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Markers Of Oxidative Stress ◽  
Corticosterone Treatment

The effects of CeO2 nanoparticle (CeNPs) on oxidative stress biomarkers of rat liver mitochondria: In vitro study ‏

2020 ◽  
Vol 10 ◽  
Author(s):  
Mona Pourjafar ◽  
Sara Malih ◽  
Akram Ranjbar
Keyword(s):  
Oxidative Stress ◽  
Rat Liver ◽  
Antioxidant Properties ◽  
In Vitro Study ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Oxidative Stress Biomarkers ◽  
Beneficial Effects ◽  
Stress Biomarkers

: In recent years, the applications of nanoparticles have received a great attention due to their industrial and biomedical applications, while their beneficial effects suffer from controversial results at clinical stages. In the current study, cytotoxicity of cerium oxide (CeNP) nanoparticles (100 nm) were evaluated using mitochondria derived from wistar rat's liver. Isolated mitochondria from rat’s liver were divided into 7 groups including group 1 as control and group 2 to 7 as treatment group with different doses of CeNP (5, 10, 50, 100, 250 and 500mg/ml, respectively), for 24,48 and 72 hours. After exposure, oxidative stress biomarkers such as total ‎antioxidant capacity (TAC), lipid peroxidation (LPO), total thiol groups (TTG), catalase activity (CAT) and mitochondrial viability, were determined in isolated rat liver mitochondria. Results have shown that CeNPs increase TAC, TTG, CAT, LPO and viability of mitochondria in various exposure times and confirm antioxidant properties of CeNPs in mithocondria while mitochondria is a main source for the generation of reactive oxygen species (ROS).

scholarly journals Tetrandrine concentrations not affecting oxidative phosphorylation protect rat liver mitochondria from oxidative stress

Mitochondrion ◽  
2006 ◽  
Vol 6 (4) ◽  
pp. 176-185 ◽  
Author(s):  
Maria A.S. Fernandes ◽  
José B.A. Custódio ◽  
Maria S. Santos ◽  
António J.M. Moreno ◽  
Joaquim A.F. Vicente
Keyword(s):  
Oxidative Stress ◽  
Oxidative Phosphorylation ◽  
Rat Liver ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria

Toxicity of thallium on isolated rat liver mitochondria: The role of oxidative stress and MPT pore opening

2013 ◽  
Vol 30 (2) ◽  
pp. 232-241 ◽  
Author(s):  
M R Eskandari ◽  
Vida Mashayekhi ◽  
Majid Aslani ◽  
Mir-Jamal Hosseini
Keyword(s):  
Oxidative Stress ◽  
Rat Liver ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Isolated Rat Liver ◽  
Pore Opening ◽  
Isolated Rat

Oxaliplatin-induced Oxidative Stress Provokes Toxicity in Isolated Rat Liver Mitochondria

2015 ◽  
Vol 46 (8) ◽  
pp. 597-603 ◽  
Author(s):  
Heena Tabassum ◽  
Mohammad Waseem ◽  
Suhel Parvez ◽  
M. Irfan Qureshi
Keyword(s):  
Oxidative Stress ◽  
Rat Liver ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Isolated Rat Liver ◽  
Isolated Rat

scholarly journals BISPHENOL A DOSE- AND TIME-DEPENDENTLY INDUCES OXIDATIVE STRESS IN RAT LIVER MITOCHONDRIA EX VIVO

2018 ◽  
Vol 11 (9) ◽  
pp. 98 ◽  
Author(s):  
Mousumi Dutta ◽  
Goutam Paul
Keyword(s):  
Oxidative Stress ◽  
Bisphenol A ◽  
Rat Liver ◽  
Ex Vivo ◽  
Liver Mitochondria ◽  
Time Dependent ◽  
Incubation Mixture ◽  
Rat Liver Mitochondria ◽  
Control Group ◽  
Dependent Manner

Objective: The probable toxic effects of bisphenol A (BPA) on different physiological functions have been reported in animal models. The role of BPA in mitochondrial oxidative stress has not been reported till date. The present study is aimed to elucidate dose- and time-dependent oxidative stress generation by BPA, respectively, in rat liver mitochondria in ex vivo model. Methods: The incubation mixture of BPA-treated groups containing mitochondria, 50 mM potassium phosphate buffer (pH 7.4), and different concentrations of BPA (20–160 μM/ml) (dissolved in 12% DMSO) in a final volume of 1.0 ml was incubated at 37°C in incubator for different time durations (30 min–2 h). Whereas, the incubation mixture of control group contained DMSO (12%), mitochondria and 50 mM potassium phosphatebuffer (pH 7.4).’ will be replaced by ‘Whereas, the incubation mixture of control group contained the same constituents except BPA. Result: We have observed significant decrease in mitochondrial intactness incubated with BPA in dose- and time-dependent manner under bright field and confocal microscopic study compared to control. Further, we have observed a decrease in mitochondrial reduced glutathione (GSH) content and increase in lipid peroxidation and protein carbonylation levels in dose- and time-dependent manner in BPA-exposed mitochondria. We have found a significant increase in the activity of Mn-superoxide dismutase and decrease in the activities of GSH peroxidase, GSH reductase, pyruvate dehydrogenase, and other three enzymes of Kreb’s cycle dose and time dependently in BPA-exposed mitochondria. The results indicate that exposure to BPA leads to decrease in intactness of mitochondria and increase in oxidative stress in mitochondria isolated from rat liver in a dose- and time-dependent manner. Conclusion: It can be concluded that the incubation of mitochondria isolated from rat liver with BPA, caused oxidative stress-mediated damages in mitochondria in both dose- and time-dependent manners.

Sign in / Sign up

Export Citation Format

Share Document