scholarly journals Diet composition and lipoprotein lipase (EC 3.1.1.34) activity in human obesity

1987 ◽  
Vol 58 (1) ◽  
pp. 13-21 ◽  
Author(s):  
Lori A. Smolin ◽  
Mary B. Grosvenor ◽  
David J. Handelsman ◽  
Jo Anne Brasel
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Lipoprotein Lipase ◽  
Diet Composition ◽  
Weight Maintenance ◽  
High Protein Diet ◽  
Obese Women ◽  
Human Obesity ◽  
Adipose Tissue Lipoprotein Lipase ◽  
Rate Limiting

1. Adipose tissue lipoprotein lipase (EC 3.1.1.34; AT-LPL), a rate-limiting enzyme in triglyceride storage in adipose tissue, is hormonally regulated and may be important in the maintenance of obesity.2. In twelve obese women, AT-LPL activity was measured before weight loss, during weight loss and after 1 and 2 weeks of weight maintenance on either a high-carbohydrate or a high-protein diet.3. When related to tissue weight, AT-LPL activity during the 2 weeks of weight maintenance was higher than the initial AT-LPL activity; there was no difference when activity was expressed per cell.4. Changes in AT-LPL activity were not affected by diet composition. AT-LPL activity correlated with insulin levels and a change in the insulin sensitivity of AT-LPL was observed after weight loss.

Prolactin and Insulin Ultradian Secretion and Adipose Tissue Lipoprotein lipase Expression in Severely Obese Women After Bariatric Surgery

Obesity ◽  
2008 ◽  
Vol 16 (8) ◽  
pp. 1831-1837 ◽  
Author(s):  
Geltrude Mingrone ◽  
Melania Manco ◽  
Amerigo Iaconelli ◽  
Donatella Gniuli ◽  
Roberto Bracaglia ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Adipose Tissue ◽  
Lipoprotein Lipase ◽  
Obese Women ◽  
Severely Obese ◽  
Adipose Tissue Lipoprotein Lipase ◽  
Lipase Expression

Responses of adipose tissue lipoprotein lipase to weight loss affect lipid levels and weight regain in women

2000 ◽  
Vol 279 (5) ◽  
pp. E1012-E1019 ◽  
Author(s):  
Barbara J. Nicklas ◽  
Ellen M. Rogus ◽  
Dora M. Berman ◽  
Karen E. Dennis ◽  
Andrew P. Goldberg
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Postmenopausal Women ◽  
Lipoprotein Lipase ◽  
Weight Regain ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Total Body Weight ◽  
Fat Distribution ◽  
Adipose Tissue Lipoprotein Lipase

This study determines whether changes in abdominal (ABD) and gluteal (GLT) adipose tissue lipoprotein lipase (LPL) activity in response to a 6-mo weight loss intervention, comprised of a hypocaloric diet and low-intensity walking, affect changes in body composition, fat distribution, lipid metabolism, and the magnitude of weight regain in 36 obese postmenopausal women. Average adipose tissue LPL activity did not change with an average 5.6-kg weight loss, but changes in LPL activity were inversely related to baseline LPL activity (ABD: r= −0.60, GLT: r = −0.48; P < 0.01). The loss of abdominal body fat and decreases in total and low-density lipoprotein cholesterol were greater in women whose adipose tissue LPL activity decreased with weight loss despite a similar loss of total body weight and fat mass. Moreover, weight regain after a 6-mo follow-up was less in women whose adipose tissue LPL activity decreased than in women whose LPL increased (ABD: 0.9 ± 0.5 vs. 2.8 ± 0.6 kg, P < 0.05; GLT: 0.2 ± 0.5 vs. 2.8 ± 0.5 kg, P < 0.01). These results suggest that a reduction in adipose tissue LPL activity with weight loss is associated with improvements in lipid metabolic risk factors with weight loss and with diminished weight regain in postmenopausal women.

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