scholarly journals Urinary excretion of magnesium and calcium as an index of absorption is not affected by lactose intake in healthy adults

1993 ◽  
Vol 69 (3) ◽  
pp. 863-870 ◽  
Author(s):  
Elizabeth J. Brink ◽  
Emerentia C. H. van Beresteijn ◽  
Pieter R. Dekker ◽  
Anton C. Beynen
Keyword(s):  
Urinary Excretion ◽  
Dairy Products ◽  
Healthy Adults ◽  
Cow’S Milk ◽  
Double Blind ◽  
Cow's Milk ◽  
Adult Volunteers ◽  
Hydrolysis Of ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

The effect of lactose on the urinary excretion of Mg and Ca, as an index of absorption, was studied in a double-blind, crossover study during three 1-week periods. Twenty-four healthy, lactose-tolerant, adult volunteers maintained their habitual diets with the exception that all lactose-containing dairy products in the diet were replaced by 600 g/d of three specially prepared dairy products. These products were based on either lactose-enriched cow's milk or lactose-enriched, lactase (EC3.2.1.23)-treated cow's milk, with or without added Mg, and were given in turn during 1 week. Lactose intake was increased by 127 mmol/d (46 g/d) while taking the lactose-enriched products. While taking the Mg-enriched products, Mg intake was increased by 2.8 mmol/d (69 mg/d) which was equivalent to 17% of the habitual Mg intake. Apart from the lactose and Mg intake, nutrient intake was comparable during the three dietary periods. Urinary excretions of Mg and Ca were used as indicators for their absorption. Mg supplementation significantly increased urinary Mg excretion by 0.97 mmol/d (equivalent to an increase of 18%,P< 0.001), indicating that urinary Mg excretion is a valid indicator for intestinal Mg absorption. Hydrolysis of lactose did not affect urinary excretion of Mg and Ca, which implies that lactose intake does not affect the absorption of Mg and Ca in healthy adults.

Cow's Milk Whey Protein Elicits Symptoms of Infantile Colic in Colicky Formula-Fed Infants: A Double-Blind Crossover Study

PEDIATRICS ◽  
1989 ◽  
Vol 83 (2) ◽  
pp. 262-266 ◽  
Author(s):  
Lasse Lothe ◽  
Tor Lindberg
Keyword(s):  
Crossover Study ◽  
Whey Protein ◽  
Cow’S Milk ◽  
Infantile Colic ◽  
Double Blind ◽  
Milk Whey ◽  
Cow's Milk ◽  
The Mean ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

There are several causes of infantile colic. The aim of this study was to evaluate, under controlled conditions, whether bovine whey proteins can elicit symptoms of infantile colic in colicky formula-fed infants. The mean age for entering the study was 6.4 weeks and the mean age for colic debut was 3.7 weeks. In 24 of 27 infants with severe colic, the symptoms disappeared when they were given a cow's milk-free diet (Nutramigen). These 24 infants were entered into a double-blind crossover study. The infants (receiving cow's milk-free diet) were given the contents of identical capsules with each meal during day 6. The same procedure was repeated on day 10. The capsules contained either whey protein powder (with Nutramigen added) or human albumin powder (with Nutramigen added). Eighteen infants receiving the whey protein-containing capsules reacted with colic, two infants receiving placebo reacted with colic (P&lt; .001), and four infants did not react at all. Crying hours per day for the 24 infants were 5.6 hours for formula-fed infants and 0.7 hour for cow's milk-free diet-fed infants (P&lt; .001). Crying hours per day were 3.2 hours for the infants receiving whey protein capsules and 1.0 hour for those receiving placebo (P&lt; .001). In conclusion, bovine whey protein can elicit symptoms of infantile colic in colicky formula-fed infants.

ERRATA

PEDIATRICS ◽  
1989 ◽  
Vol 84 (1) ◽  
pp. 17-17
Keyword(s):  
Crossover Study ◽  
Whey Protein ◽  
Cow’S Milk ◽  
Infantile Colic ◽  
Double Blind ◽  
Milk Whey ◽  
Cow's Milk ◽  
Blind Crossover Study ◽  
Milk Whey Protein ◽  
Double Blind Crossover Study

In the article, "Cow's Milk Whey Protein Elicits Symptoms of Infantile Colic in Colicky Formula-Fed Infants: A Double-Blind Crossover Study," by Lothe and Lindberg (Pediatrics 1989;83:262-266), there was an error on page 264. The second sentence in "Results" should have read: Infants receiving cow's milkbased formula cried 3 h/d or more.

scholarly journals Diosgenin-Rich Yam Extract Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind, Crossover Study of Healthy Adults

Nutrients ◽  
2017 ◽  
Vol 9 (10) ◽  
pp. 1160 ◽  
Author(s):  
Chihiro Tohda ◽  
Ximeng Yang ◽  
Mie Matsui ◽  
Yuna Inada ◽  
Emika Kadomoto ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Crossover Study ◽  
Healthy Adults ◽  
Double Blind ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

scholarly journals Bioavailability of magnesium and calcium from cow's milk and soya-bean beverage in rats

1992 ◽  
Vol 68 (1) ◽  
pp. 271-282 ◽  
Author(s):  
Elizabeth J. Brink ◽  
Pieter R. Dekker ◽  
Emerentia C. H. Van Beresteijn ◽  
Anton C. Beynen
Keyword(s):  
Urinary Excretion ◽  
Bone Mineralization ◽  
Body Weight Gain ◽  
Inhibitory Effect ◽  
Soya Bean ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Apparent Absorption ◽  
Hydroxyproline Excretion ◽  
Hydrolysis Of

The milk components lactose and casein enhance the apparent absorption of magnesium and possibly also of calcium, whereas phytate, which occurs in soya-bean products, has an inhibitory effect. This implies that soya-bean beverage v. cow's milk could lower bioavailability of Mg and Ca. This hypothesis was tested in two experiments with growing rats. Feeding soya-bean beverage v. cow's milk consistently lowered body-weight gain, enhanced bone turnover, as measured by increased plasma alkaline phosphatase (EC 3.1.3.1) activity and increased urinary hydroxyproline excretion, and decreased Mg and Ca concentrations in the femur. Because the mineral compositions of the soya-bean beverage and the cow's milk were different, the intake of Mg was higher in rats fed on soya-bean beverage, whereas that of Ca was higher in rats fed on cow's milk. Supplementation of the soya-bean beverage either with phosphorus and Ca or with P, Ca and methionine, to concentrations identical to those in milk, restored growth and bone mineralization. When using diets carefully balanced for Mg, Ca, P, sodium, potassium and methionine, soya-bean beverage v. cow's milk in the diets decreased apparent absorption and urinary excretion of Mg and Ca. Hydrolysis of lactose in milk decreased absorption and urinary excretion of Mg; it did not significantly affect Ca absorption but lowered urinary Ca excretion. The present study shows that soya-bean beverage v. milk depresses Mg and Ca bioavailability, as would be predicted on the basis of reported effects of their purified components.

Too Few Cases

PEDIATRICS ◽  
1983 ◽  
Vol 72 (2) ◽  
pp. 267-267
Author(s):  
G. B. Stickler
Keyword(s):  
Crossover Study ◽  
Crossover Trial ◽  
Review Process ◽  
Milk Proteins ◽  
Cow’S Milk ◽  
Infantile Colic ◽  
Double Blind ◽  
Blind Crossover Study ◽  
Breast Fed ◽  
Double Blind Crossover Study

After reading the article by Jakobsson and Lindberg "Cow's Milk Proteins Cause Infantile Colic in Breast-Fed Infants: A Double-Blind Crossover Study" (Pediatrics 1983;71:268-271), I am wondering a little bit what is happening to the review process. The study supposedly shows experience with 66 breast-fed infants. However, the critical double-blind crossover trial was completed successfully only with ten. It is not clear why the article was published including 50 children who were not studied objectively. I do believe a paper of this sort will cause a great deal of alarm on data based on much to small a sample.

Pharmacokinetics and Tolerability of Factor XIII Concentrates Prepared from Human Placenta or Plasma: a Crossover Randomised Study

1995 ◽  
Vol 74 (02) ◽  
pp. 622-625 ◽  
Author(s):  
H H Brackmann ◽  
R Egbring ◽  
A Ferster ◽  
P Fondu ◽  
J M Girardel ◽  
...  
Keyword(s):  
Factor Xiii ◽  
Bleeding Events ◽  
Serious Adverse Events ◽  
Double Blind ◽  
Randomised Study ◽  
The Mean ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study ◽  
Fxiii Activity ◽  
Observation Period

SummaryThe pharmacokinetics and tolerability of factor XIII (FXIII) from plasma were compared with those of FXIII from placenta in a randomised, double-blind, crossover study involving 13 patients with congenital FXIII deficiency. Both FXIII activity and FXIII antigen were monitored. No difference was seen in the mean half-lives of the two preparations (9.3 days and 9.1 days for plasma and placenta FXIII activity, respectively). Response was similar for both preparations, but was slightly greater for FXIII from plasma.Similar results were found for recovery (65% vs 60%). The area under the data completed by extrapolation was significantly higher for FXIII from plasma. No differences between preparations in terms of efficacy or tolerability were observed. It can be concluded that treatment with FXIII concentrate from plasma is as efficient as with FXIII concentrate from placenta in terms of recovery and half-life. Both preparations were equivalent in terms of safety during the observation period. With the administration of monthly injections of approximately 30 U/kg serious bleeding events were prevented and no other serious adverse events occurred.

Inhibition of Spontaneous Platelet Aggregation by Sulfinpyrazone

1979 ◽  
Vol 42 (02) ◽  
pp. 621-625 ◽  
Author(s):  
G G Nenci ◽  
G Agnelli ◽  
M Berrettini ◽  
P Parise ◽  
E Ballatori
Keyword(s):  
Platelet Aggregation ◽  
Crossover Study ◽  
Double Blind ◽  
Platelet Aggregability ◽  
Initiation Of Therapy ◽  
Spontaneous Platelet Aggregation ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

SummaryIn a randomized double-blind crossover study in 16 patients with enhanced in vitro spontaneous platelet aggregation, sulfinpyrazone proved to be effective in normalizing platelet aggregability within 4 days after initiation of therapy.

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