Interaction of fish oil and a glucocorticoid on metabolic responses to an oral glucose load in healthy human subjects

Compared with saturated fat, n-3 long-chain PUFA-rich fish oil improves insulin sensitivity in rats. We studied whether n-3 long-chain PUFA could prevent insulin resistance induced by dexamethasone (a glucocorticoid) in healthy human volunteers. A group of eight subjects was studied twice after a 2d dexamethasone treatment, before and after a 3-week supplementation with fish oil (providing daily doses of 1·1g 20:5n-3 and 0·7g 22:6n-3). The subjects were studied during the basal state and over the 6h following an oral glucose load (1g/kg). Plasma glucose fluxes were traced with [6,6-2H2]glucose and [13C]glucose (naturally 13C-enriched corn glucose). Substrate oxidation was obtained from indirect calorimetry. Following fish oil supplementation, plasma glucose fluxes and substrate oxidation were maintained despite a 17% reduction (P<0·05) in the area under the curve of plasma insulin response, suggesting an insulin-sensitizing effect.

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Usefulness of Revised Fasting Plasma Glucose Criterion and Characteristics of the Insulin Response to an Oral Glucose Load in Newly Diagnosed Japanese Diabetic Subjects

Diabetes Care ◽

10.2337/diacare.21.7.1133 ◽

1998 ◽

Vol 21 (7) ◽

pp. 1133-1137 ◽

Cited By ~ 48

Author(s):

Y. Tanaka ◽

Y. Atsumi ◽

T. Asahina ◽

K. Hosokawa ◽

K. Matsuoka ◽

...

Keyword(s):

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Insulin Response ◽

Oral Glucose ◽

Newly Diagnosed ◽

Oral Glucose Load ◽

Glucose Load ◽

Fasting Plasma

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Relationship between insulin response to oral glucose load and creatinine clearance

Diabetes ◽

10.2337/diabetes.24.12.1066 ◽

1975 ◽

Vol 24 (12) ◽

pp. 1066-1071 ◽

Cited By ~ 1

Author(s):

K. Yasuda ◽

T. Sato ◽

T. Furuyama ◽

K. Yashinaga

Keyword(s):

Creatinine Clearance ◽

Insulin Response ◽

Oral Glucose ◽

Oral Glucose Load ◽

Glucose Load

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Enhanced Insulin Response to Oral Glucose Load in Patients with Angina Pectoris Associated with ST Segment Elevation in the Absence of Epicardial Coronary Arterial Obstruction

Angiology ◽

10.1177/000331979804900905 ◽

1998 ◽

Vol 49 (9) ◽

pp. 815-826 ◽

Cited By ~ 2

Author(s):

Shigeo Takata ◽

Atsuhiro Shimakura ◽

Satoru Sakagami ◽

Yukio Nakamura ◽

Hitoshi Ohkuwa ◽

...

Keyword(s):

Angina Pectoris ◽

Insulin Response ◽

Oral Glucose ◽

Oral Glucose Load ◽

Glucose Load ◽

St Segment Elevation ◽

St Segment

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Plasma Insulin Response to An Oral Glucose Load in Noncoronary Heart Disease

CHEST Journal ◽

10.1378/chest.59.2.184 ◽

1971 ◽

Vol 59 (2) ◽

pp. 184-187

Author(s):

Wilbert S. Aronow ◽

John R. Kent

Keyword(s):

Heart Disease ◽

Plasma Insulin ◽

Insulin Response ◽

Oral Glucose ◽

Oral Glucose Load ◽

Glucose Load ◽

Plasma Insulin Response

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Interesting insulin response to oral glucose load in young Japanese subjects with impaired glucose tolerance

Diabetes Care ◽

10.2337/diacare.23.5.710 ◽

2000 ◽

Vol 23 (5) ◽

pp. 710-712 ◽

Cited By ~ 9

Author(s):

Y. Tanaka ◽

Y. Atsumi ◽

K. Matsuoka ◽

T. Onuma ◽

R. Kawamori

Keyword(s):

Glucose Tolerance ◽

Impaired Glucose Tolerance ◽

Insulin Response ◽

Oral Glucose ◽

Oral Glucose Load ◽

Glucose Load ◽

Japanese Subjects

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Plasma glucose thresholds for counterregulation after an oral glucose load

Metabolism ◽

10.1016/0026-0495(94)90163-5 ◽

1994 ◽

Vol 43 (1) ◽

pp. 98-103 ◽

Cited By ~ 5

Author(s):

Pauline Genter ◽

Eli Ipp

Keyword(s):

Plasma Glucose ◽

Oral Glucose ◽

Oral Glucose Load ◽

Glucose Load

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Effect of an enkephalin-analogue (FK 33-824) on glucose tolerance in man

Acta Endocrinologica ◽

10.1530/acta.0.1040085 ◽

1983 ◽

Vol 104 (1) ◽

pp. 85-90 ◽

Cited By ~ 6

Author(s):

X. Jeanrenaud ◽

E. Maeder ◽

E. Del Pozo ◽

J. P. Felber

Keyword(s):

Glucose Tolerance ◽

Insulin Response ◽

Normal Subjects ◽

Glucose Absorption ◽

Oral Glucose ◽

Oral Glucose Load ◽

Glucose Load ◽

Oral Test ◽

Insulin Response To Glucose ◽

Glucose Curve

Abstract. The purpose of the present work was to study the effect of a methionine-enkephalin analogue (FK 33-824) on glucose tolerance in man. Groups of 5 to 8 normal subjects were given a 0.5 mg im injection of the drug or placebo just before a 100 g oral glucose load or a 0.5 g/kg iv glucose load. In the enkephalin analogue treated subjects, diminished insulin response to glucose was observed following the oral glucose load, with insulin values significantly lower than in the controls from time 10 to 90 min, but no corresponding change in the glucose curve. This effect was not observed when glucose was given iv in another group of 5 subjects in whom the significant blunting of the insulin response was accompanied by a significant decrease in glucose tolerance. These observations demonstrate that in man, enkephalin produces a decrease in insulin secretion in response to both oral and iv glucose loads. The absence of any marked impairment in glucose tolerance in the oral test in spite of the decreased insulin response suggests that enkephalin might have an additional effect in delaying glucose absorption.

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