Plasma glucose thresholds for counterregulation after an oral glucose load

Metabolism ◽  
1994 ◽  
Vol 43 (1) ◽  
pp. 98-103 ◽  
Author(s):  
Pauline Genter ◽  
Eli Ipp
Keyword(s):  
Plasma Glucose ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load

Metoprolol in Diabetes Mellitus: Effect on Glucose Homeostasis

1980 ◽  
Vol 59 (s6) ◽  
pp. 469s-472s ◽  
Author(s):  
B. N. Garrett ◽  
P. Raskin ◽  
N. M. Kaplan
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Plasma Renin Activity ◽  
Glucose Homeostasis ◽  
Plasma Glucose ◽  
Plasma Renin ◽  
Renin Activity ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load

1. In eight hypertensive diabetic subjects receiving hydrochlorothiazide, glucose homeostasis as measured by the changes in plasma glucose, insulin and glucagon after an oral glucose load was not significantly affected by 8 weeks of therapy with metoprolol. 2. The combination of metoprolol plus hydrochlorothiazide significantly lowered blood pressure in all subjects. 3. Plasma renin activity was suppressed by therapy with metoprolol.

Effects of hyperglycemia on glucose metabolism before and after oral glucose ingestion in normal men

2006 ◽  
Vol 290 (6) ◽  
pp. E1198-E1204 ◽  
Author(s):  
Vincent Rigalleau ◽  
Marie-Christine Beauvieux ◽  
Jean-Louis Gallis ◽  
Henri Gin ◽  
Phillippe Schneiter ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Plasma Glucose ◽  
Glucose Disposal ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Glucose Ingestion ◽  
Before And After ◽  
Endogenous Glucose ◽  
Normal Men

The plasma glucose excursion may influence the metabolic responses after oral glucose ingestion. Although previous studies adressed the effects of hyperglycemia in conditions of hyperinsulinemia, it has not been evaluated whether the route of glucose administration (oral vs. intravenous) plays a role. Our aim was to determine the effects of moderately controlled hyperglycemia on glucose metabolism before and after oral glucose ingestion. Eight normal men underwent two oral glucose clamps at 6 and 10 mmol/l plasma glucose. Glucose turnover and cycling rates were measured by infusion of [2H7]glucose. The oral glucose load was labeled by d-[6,6-2H2]glucose to monitor exogenous glucose appearance, and respiratory exchanges were measured by indirect calorimetry. Sixty percent of the oral glucose load appeared in the systemic circulation during both the 6 and 10 mmol/l plasma glucose tests, although less endogenous glucose appeared during the 10 mmol/l tests before glucose ingestion ( P < 0.05). This inhibitory effect of hyperglycemia was not detectable after oral glucose ingestion, although glucose utilization was increased (+28%, P < 0.05) due to increased nonoxidative glucose disposal [10 vs. 6 mmol/l: +20%, not significant (NS) before oral glucose ingestion; +40%, P < 0.05 after oral glucose ingestion]. Glucose cycling rates were increased by hyperglycemia (+13% before oral glucose ingestion, P < 0.001; +31% after oral glucose ingestion, P < 0.05) and oral glucose ingestion during both the 6 (+10%, P < 0.05) and 10 mmol/l (+26%, P < 0.005) tests. A moderate hyperglycemia inhibits endogenous glucose production and contributes to glucose tolerance by enhancing nonoxidative glucose disposal. Hyperglycemia and oral glucose ingestion both stimulate glucose cycling.

scholarly journals Lean mass inversely predicts plasma glucose levels after oral glucose load independent of insulin secretion or insulin sensitivity in glucose intolerance subjects

2014 ◽  
Vol 61 (1) ◽  
pp. 77-83 ◽  
Author(s):  
Jirateep Kwankaew ◽  
Sunee Saetung ◽  
Suwannee Chanprasertyothin ◽  
Rattana Leelawattana ◽  
Chatchalit Rattarasarn
Keyword(s):  
Insulin Secretion ◽  
Insulin Sensitivity ◽  
Glucose Intolerance ◽  
Lean Mass ◽  
Plasma Glucose ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Glucose Levels

Diurnal changes in plasma glucose and insulin responses to oral glucose load in rats

1980 ◽  
Vol 238 (5) ◽  
pp. E463-E466 ◽  
Author(s):  
E. Hara ◽  
M. Saito
Keyword(s):  
Plasma Glucose ◽  
Diurnal Variations ◽  
Oral Glucose ◽  
Diurnal Changes ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Feeding Schedule ◽  
Insulin Responses

The plasma glucose and insulin responses to an oral load of glucose were examined in the daytime and at night in unanesthetized and unrestrained rats. In rats that had been fed during the nighttime (2200-0400 h) every day for 2 wk, the plasma glucose and insulin responses were significantly greater (P less than 0.05) at night (2200-2400 h) than in the daytime (1000-1200 h). In rats that had been fed during the daytime (1000-1600 h), the plasma glucose and insulin responses were greater in the daytime than at night (P less than 0.05). It was concluded that the diurnal variations in the plasma glucose and insulin responses to an oral glucose load are closely related to the feeding schedule on which the rats are kept.

The Effect of Encapsulated Soluble Fiber on Carbohydrate Metabolism during Exercise

1999 ◽  
Vol 9 (1) ◽  
pp. 13-23 ◽  
Author(s):  
Allen C. Parcell ◽  
Melinda L. Ray ◽  
Kristine A. Moss ◽  
Timothy M. Ruden ◽  
Rick L. Sharp ◽  
...  
Keyword(s):  
Carbohydrate Metabolism ◽  
Plasma Glucose ◽  
Muscle Glycogen ◽  
Guar Gum ◽  
Metabolic Responses ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Soluble Fiber ◽  
Glycogen Utilization

Previous investigations have reported that soluble fiber reduces the plasma glucose and insulin changes after an oral glucose load. To improve the payability of a soluble-fiber feeding, this study addressed how a combined, soluble fiber (delivered in capsule form) and a preexercise CHO feeding would affect metabolic responses during exercise. On 3 different days, participants ingested a placebo (CON), 75 g liquid CHO (GLU), or 75 g liquid CHO with 14.5 g encapsulated guar gum (FIB) 45 min before cycling for 60 min at 70% VO2peak. Peak concentrations of plasma glucose and insulin were similar and significantly greater than CON preexercise (p < .05). Similarities in carbohydrate reliance were observed in GLU and FIB. Muscle glycogen use did not differ significantly among trials. These results demonstrate that encapsulated soluble fiber delivered with a liquid CHO feeding does not affect plasma glucose, insulin, or muscle glycogen utilization during exercise.

scholarly journals Relationship of HbA1c with Fasting and Plasma Glucose 2 Hours after Oral Glucose Load in Non Diabetic and Newly Diagnosed Pre Diabetic and Diabetic Patients

2012 ◽  
Vol 2 (2) ◽  
pp. 81-83
Author(s):  
Tanjina Hossain ◽  
Zafar Ahmed Latif ◽  
Abdullah Al-mamun Sarkar
Keyword(s):  
Correlation Coefficient ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Oral Glucose ◽  
Diabetic Patients ◽  
Moderate Degree ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Fasting Plasma ◽  
Relationship Of

Objectives: This study was conducted to assess the relationship of Fasting Plasma Glucose and Plasma Glucose 2 hours after 75 gram glucose load with HbA1c in subjects who were not detected before as diabetic, pre diabetic or non diabetic. Methods: Total eight hundred and seventy eight subjects of both sexes coming to do for an Oral Glucose Tolerance Test (OGTT) were included in the study. Fasting and plasma glucose 2 hours after 75 gram glucose load were measured by hexokinase method. HbA1c was measured by high performance liquid chromatography (HPLC) method. Results: According to OGTT among the total study subjects 48.7%(n=428) had DM, 17.1% (n=150) had Pre DM and 34.2% (n=300) were non diabetic. Correlation coefficient between Fasting Plasma Glucose and HbA1c was 0.551 (p.000) and correlation coefficient between HbA1c and plasma glucose at 2 hours after oral glucose load was 0.475 (p.000). Conclusion: This study showed moderate degree of relationship between Fasting Plasma Glucose and HbA1c and between HbA1c and plasma glucose 2 hours after 75 gram glucose load in population never diagnosed before as diabetic, pre diabetic or non diabetic. DOI: http://dx.doi.org/10.3329/birdem.v2i2.12307Birdem Med J 2012; 2(2) 81-83

scholarly journals Interaction of fish oil and a glucocorticoid on metabolic responses to an oral glucose load in healthy human subjects

2006 ◽  
Vol 95 (2) ◽  
pp. 267-272 ◽  
Author(s):  
Jacques Delarue ◽  
Chang-Hong Li ◽  
Richard Cohen ◽  
Charlotte Corporeau ◽  
Brigitte Simon
Keyword(s):  
Fish Oil ◽  
Plasma Glucose ◽  
Insulin Response ◽  
Substrate Oxidation ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Healthy Human ◽  
Chain Pufa ◽  
Long Chain

Compared with saturated fat, n-3 long-chain PUFA-rich fish oil improves insulin sensitivity in rats. We studied whether n-3 long-chain PUFA could prevent insulin resistance induced by dexamethasone (a glucocorticoid) in healthy human volunteers. A group of eight subjects was studied twice after a 2d dexamethasone treatment, before and after a 3-week supplementation with fish oil (providing daily doses of 1·1g 20:5n-3 and 0·7g 22:6n-3). The subjects were studied during the basal state and over the 6h following an oral glucose load (1g/kg). Plasma glucose fluxes were traced with [6,6-2H2]glucose and [13C]glucose (naturally 13C-enriched corn glucose). Substrate oxidation was obtained from indirect calorimetry. Following fish oil supplementation, plasma glucose fluxes and substrate oxidation were maintained despite a 17% reduction (P<0·05) in the area under the curve of plasma insulin response, suggesting an insulin-sensitizing effect.

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