Usefulness of Revised Fasting Plasma Glucose Criterion and Characteristics of the Insulin Response to an Oral Glucose Load in Newly Diagnosed Japanese Diabetic Subjects

Diabetes Care ◽  
1998 ◽  
Vol 21 (7) ◽  
pp. 1133-1137 ◽  
Author(s):  
Y. Tanaka ◽  
Y. Atsumi ◽  
T. Asahina ◽  
K. Hosokawa ◽  
K. Matsuoka ◽  
...  
Keyword(s):  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Insulin Response ◽  
Oral Glucose ◽  
Newly Diagnosed ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Fasting Plasma

scholarly journals Relationship of HbA1c with Fasting and Plasma Glucose 2 Hours after Oral Glucose Load in Non Diabetic and Newly Diagnosed Pre Diabetic and Diabetic Patients

2012 ◽  
Vol 2 (2) ◽  
pp. 81-83
Author(s):  
Tanjina Hossain ◽  
Zafar Ahmed Latif ◽  
Abdullah Al-mamun Sarkar
Keyword(s):  
Correlation Coefficient ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Oral Glucose ◽  
Diabetic Patients ◽  
Moderate Degree ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Fasting Plasma ◽  
Relationship Of

Objectives: This study was conducted to assess the relationship of Fasting Plasma Glucose and Plasma Glucose 2 hours after 75 gram glucose load with HbA1c in subjects who were not detected before as diabetic, pre diabetic or non diabetic. Methods: Total eight hundred and seventy eight subjects of both sexes coming to do for an Oral Glucose Tolerance Test (OGTT) were included in the study. Fasting and plasma glucose 2 hours after 75 gram glucose load were measured by hexokinase method. HbA1c was measured by high performance liquid chromatography (HPLC) method. Results: According to OGTT among the total study subjects 48.7%(n=428) had DM, 17.1% (n=150) had Pre DM and 34.2% (n=300) were non diabetic. Correlation coefficient between Fasting Plasma Glucose and HbA1c was 0.551 (p.000) and correlation coefficient between HbA1c and plasma glucose at 2 hours after oral glucose load was 0.475 (p.000). Conclusion: This study showed moderate degree of relationship between Fasting Plasma Glucose and HbA1c and between HbA1c and plasma glucose 2 hours after 75 gram glucose load in population never diagnosed before as diabetic, pre diabetic or non diabetic. DOI: http://dx.doi.org/10.3329/birdem.v2i2.12307Birdem Med J 2012; 2(2) 81-83

Glucose tolerance in early pregnancy

1986 ◽  
Vol 112 (2) ◽  
pp. 263-266 ◽  
Author(s):  
Inge Buch ◽  
Peter J. Hornnes ◽  
Claus Kühl
Keyword(s):  
Glucose Tolerance ◽  
Glucose Homeostasis ◽  
Early Pregnancy ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Post Partum ◽  
Insulin Response ◽  
Oral Glucose ◽  
Plasma Glucagon ◽  
Fasting Plasma

Abstract. The effect of pregnancy on oral glucose tolerance (50 g of glucose) and plasma insulin and glucagon responses to oral glucose was studied in weeks 10 and 32 of pregnancy and again 1 year post partum in 12 normal women. Already in week 10, fasting plasma glucose was decreased and the glucose-induced insulin secretion increased as compared with post partum. However, glucose tolerance was not affected at this time. In week 32, glucose tolerance had deteriorated, although the levels of both fasting and glucose-induced insulin were higher than those found in early pregnancy and post partum. At all investigations fasting plasma glucagon and the suppression of plasma glucagon after oral glucose were similar, indicating that glucagon is not implicated in the changes in glucose homeostasis seen in pregnancy. It is concluded that glucose tolerance is unaltered by pregnancy in week 10. Pregnancy has, however, at this very early stage already affected glucose homeostasis as seen by the decrease in fasting plasma glucose and the increase in the insulin response to glucose.

scholarly journals Examination of Dysglycaemia among Newly Diagnosed Tuberculosis Patients in Ghana: A Cross-Sectional Study

2018 ◽  
Vol 2018 ◽  
pp. 1-10
Author(s):  
Ernest Yorke ◽  
Vincent Boima ◽  
Ida Dzifa Dey ◽  
Yacoba Atiase ◽  
Josephine Akpalu ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Marital Status ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Sputum Smear ◽  
P Value ◽  
Oral Glucose ◽  
Newly Diagnosed ◽  
Tuberculosis Patients ◽  
Fasting Plasma

The burden of both tuberculosis (TB) and diabetes mellitus in developing countries including Ghana is high; often, the two coexist and impact each other negatively.Objective. The study aimed to determine the prevalence and predictive factors of dysglycaemia among newly diagnosed smear positive tuberculosis patients at a tertiary tuberculosis treatment centre in Ghana.Methods. Dysglycaemia at diagnosis was determined by the use of oral glucose tolerance test (OGTT), while sputum smear microscopy was used to assess the sputum status. Only smear positive patients were included in the study. Information on sociodemographic, anthropometrical, clinical, and medication history was also obtained.Results. In all, 146 participants, aged 18 to 75 years with a mean age of 38.7 years comprising 115 (78.8%) males and 31 (21.2%) females, were involved in the analysis. Upon initial screening, using fasting plasma glucose (FPG), 91.1 % had normal fasting level, 5.5 % had impaired fasting, and 3.4% were diagnosed with diabetes. Using 2-hour postprandial values (2HPP), 59.6% had normal plasma glucose, 28.8 % had impaired glucose tolerance (IGT), and 11.6 % were diagnosed with diabetes. Overall, the prevalence of dysglycaemia (i.e., impaired fasting and diabetes) was 8.9% (95% CI: 5.21–14.82%) with FPG test and 40.4% (95% CI: 32.68–48.65%) with 2HPP test. The analysis revealed that 2HPP was associated with high mean age compared to FPG (36.67 ± 13.97 versus 41.69 ± 13.97, p-value = 0.033). In addition, marital status was significantly associated with FPG status of patients(p=0.028).Conclusion. The prevalence of dysglycaemia was high among smear positive TB patients in Ghana. Higher mean age and marital status were associated with abnormal glucose tolerance and fasting plasma glucose, respectively. Clinical management of patients with tuberculosis should include screening for diabetes.

scholarly journals Interaction of fish oil and a glucocorticoid on metabolic responses to an oral glucose load in healthy human subjects

2006 ◽  
Vol 95 (2) ◽  
pp. 267-272 ◽  
Author(s):  
Jacques Delarue ◽  
Chang-Hong Li ◽  
Richard Cohen ◽  
Charlotte Corporeau ◽  
Brigitte Simon
Keyword(s):  
Fish Oil ◽  
Plasma Glucose ◽  
Insulin Response ◽  
Substrate Oxidation ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Healthy Human ◽  
Chain Pufa ◽  
Long Chain

Compared with saturated fat, n-3 long-chain PUFA-rich fish oil improves insulin sensitivity in rats. We studied whether n-3 long-chain PUFA could prevent insulin resistance induced by dexamethasone (a glucocorticoid) in healthy human volunteers. A group of eight subjects was studied twice after a 2d dexamethasone treatment, before and after a 3-week supplementation with fish oil (providing daily doses of 1·1g 20:5n-3 and 0·7g 22:6n-3). The subjects were studied during the basal state and over the 6h following an oral glucose load (1g/kg). Plasma glucose fluxes were traced with [6,6-2H2]glucose and [13C]glucose (naturally 13C-enriched corn glucose). Substrate oxidation was obtained from indirect calorimetry. Following fish oil supplementation, plasma glucose fluxes and substrate oxidation were maintained despite a 17% reduction (P<0·05) in the area under the curve of plasma insulin response, suggesting an insulin-sensitizing effect.

Relationship between insulin response to oral glucose load and creatinine clearance

Diabetes ◽  
1975 ◽  
Vol 24 (12) ◽  
pp. 1066-1071 ◽  
Author(s):  
K. Yasuda ◽  
T. Sato ◽  
T. Furuyama ◽  
K. Yashinaga
Keyword(s):  
Creatinine Clearance ◽  
Insulin Response ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load

Enhanced Insulin Response to Oral Glucose Load in Patients with Angina Pectoris Associated with ST Segment Elevation in the Absence of Epicardial Coronary Arterial Obstruction

Angiology ◽  
1998 ◽  
Vol 49 (9) ◽  
pp. 815-826 ◽  
Author(s):  
Shigeo Takata ◽  
Atsuhiro Shimakura ◽  
Satoru Sakagami ◽  
Yukio Nakamura ◽  
Hitoshi Ohkuwa ◽  
...  
Keyword(s):  
Angina Pectoris ◽  
Insulin Response ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
St Segment Elevation ◽  
St Segment

Insulin response after treatment depends on fasting plasma glucose level in NIDDM

1994 ◽  
Vol 26 (2) ◽  
pp. 129-135
Author(s):  
Kazunari Matsumoto ◽  
Shoichi Akazawa ◽  
Norio Abiru ◽  
Mayumi Yano ◽  
Miwa Ishibasi ◽  
...  
Keyword(s):  
Glucose Level ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Plasma Glucose Level ◽  
Insulin Response ◽  
Fasting Plasma Glucose Level ◽  
Fasting Plasma

scholarly journals Demographic Associations of Diabetes Status by Both Fasting Plasma Glucose Concentration and Glycated Hemoglobin in a Community Survey in Galle District, Sri Lanka

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Keddagoda Gamage Piyumi Wasana ◽  
Anoja Priyadarshani Attanayake ◽  
Thilak Priyantha Weerarathna ◽  
Kamani Ayoma Perera Wijewardana Jayatilaka
Keyword(s):  
Sri Lanka ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Glycated Hemoglobin ◽  
Diagnostic Tools ◽  
Oral Glucose ◽  
Family History Of Diabetes ◽  
Fasting Plasma ◽  
Diabetes Status ◽  
Significant Difference

Diagnostic tools used in detecting individuals with diabetes mellitus (DM) include fasting plasma glucose (FPG), glycated hemoglobin (HbA1C), and oral glucose tolerance test (OGTT). The present study was aimed to determine the demographic associations of diabetes status by both tests (FPG and HbA1C) in Galle district, Sri Lanka. 147 adults (30–60 years) who are having FPG ≥ 126 mg/dL underwent demographic evaluations and testing for HbA1C. Group 01 (diabetes status diagnosed by both tests) and group 2 (diabetes status diagnosed only by FPG) were compared using independant sample t-test and chi-square test. Logistic regression was used to study the association between the demographic factors and the diabetes status by both tests. Of the 147 study subjects, 38.1% were males, 61.9% were females, and 63.3% had a family history of diabetes among first-degree relatives (FDR). Mean age, body mass index (BMI), waist circumference (WC), FPG, and HbA1C of the participants were 48.4 ± 7.2 years, 25.1 ± 4.0 kg/m2, 88.8 ± 9.0 cm, 139.4 ± 30.1 mg/dL, and 6.4 ± 0.7%, respectively. The prevalence of diabetes based on both tests was 55.1%. There is a significant difference in mean BMI and WC while no significant differences in mean age between groups 01 and 02. No association was seen between gender and diabetes status (X2(1) = 0.086, p=0.770), while a significant difference was observed between DM among FDR and diabetes status (X2(1) = 33.215, p<0.001). Significance of odds of having diabetes by both tests with rising BMI (OR = 1.97, CI 1.15–3.36, p=0.013) and DM among FDR (OR = 7.95, CI 3.54–17.88, p=0.000) was seen. We conclude rising BMI and having DM among FDR are strongly associated with diabetes status diagnosed by both tests of FPG and HbA1C in community screening.

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