Otitis media and mastoiditis in temporal bones of prehistoric Chilean populations. A paleopathological and paleoepidemiological study

2019 ◽  
Vol 139 (4) ◽  
pp. 340-344 ◽  
Author(s):  
Marcos V. Goycoolea ◽  
Mario Castro ◽  
Marcelo Galvez ◽  
Carlos Montoya ◽  
Jorge Fuentes ◽  
...  
Keyword(s):  
Otitis Media ◽  
Temporal Bones ◽  
Chilean Populations

Multiple Otopathologic Disorders

1988 ◽  
Vol 97 (1) ◽  
pp. 14-18 ◽  
Author(s):  
Michael M. Paparella ◽  
Patricia A. Schachern ◽  
Marcos V. Goycoolea
Keyword(s):  
Otitis Media ◽  
Endolymphatic Hydrops ◽  
Pathologic Finding ◽  
Pathologic Lesions ◽  
Temporal Bones

Temporal bones (1,383) from 713 patients were studied systematically for multiple pathologic lesions. Eleven percent (152 temporal bones) were found to have more than one pathologic finding. Males (60.5%) had multiple diseases more commonly than did females (37.7%). The most frequently occurring findings were otitis media (71.1%), otosclerosis (43.4%), endolymphatic hydrops (38.8%), labyrinthitis (25.0%), and cancer (24.3%). We conclude that multiple coexisting pathologic conditions can have coincidental or causative relationships. The otolaryngologist should consider multiple pathologic conditions when diagnosing and treating diseases of the ear.

Experimental Stapedectomy

1977 ◽  
Vol 86 (4_suppl) ◽  
pp. 1-39 ◽  
Author(s):  
Gary K. Thomas
Keyword(s):  
Bone Formation ◽  
Otitis Media ◽  
Endolymphatic Hydrops ◽  
Blood Clot ◽  
Fibrous Tissue ◽  
Oval Window ◽  
New Bone Formation ◽  
Temporalis Fascia ◽  
In Series ◽  
Temporal Bones

This animal experimental study (144 cats) was designed to allow observation of the healing processes at the oval window following stapedectomy during the first two postoperative weeks. The first 61 animals (Series I) had no oval window cover except for a blood clot which might form spontaneously. The second 64 animals (Series II) had Gelfoam® as a cover to the oval window following stapedectomy. A third series of 19 animals had temporalis fascia used as the oval window cover, and these ears were studied histologically for up to nine weeks. The unoperated ear acted as a control for the operated ear in all animals and after the animals were killed, both temporal bones were decalcified, imbedded in celloidin, serially sectioned at 20μ, and every tenth section stained and mounted for histologic study. It was observed that oval window closure was effected by endosteal, periosteal, and fibrous tissue proliferation from the traumatized tissues about the oval window fenestra, and that this process was facilitated by the presence of some type of scaffolding material such as a blood clot or Gelfoam®. Temporalis fascia placed in the oval window was observed to be rapidly incorporated into a much thicker oval window neomembrane and to seal the fenestra promptly. Partial removal of the footplate also facilitated more rapid closure of the smaller oval window fenestra, but fibrous tissue and new bone formation was noted to form about bony fragments still attached at the oval window level. Free bony fragments within the vestibule were not observed to stimulate new bone formation. Suppuration was observed most frequently in Series I (no oval window cover), with 67.8% of these animals having some degree of otitis media. In Series II (Gelfoam® cover) 20.6% had otitis media, and in Series III (temporalis fascia) 21% had middle ear infection. Suppuration markedly impaired but did not completely prevent the oval window reparative processes. Animals having some type of oval window cover were noted to have a lesser incidence of suppurative labyrinthine involvement when otitis media was present. Other labyrinthine complications were observed, including endolymphatic hydrops, Wittmaack's hypotonic atrophy, as well as RBC, fibrin, and albuminous precipitates in the labyrinth. Hypotonic atrophy was observed in a high incidence of animals having rupture of one or more endolymphatic structures, suggesting a mechanical mechanism as one possible explanation for this condition. Hypotonic atrophy may represent the end-stage (collapse) in the fluctuant endolymphatic ballooning of hydrops which is seen when saccular or Reissner's membrane ruptures have occurred.

Secretory Otitis Media and Mastoid Pneumatization

1980 ◽  
Vol 89 (3_suppl) ◽  
pp. 79-82 ◽  
Author(s):  
Burkhard Hussl ◽  
Kunigunde Welzl-Mueller
Keyword(s):  
Otitis Media ◽  
Morphological Changes ◽  
Pure Tone Audiometry ◽  
Functional Results ◽  
Cell System ◽  
Secretory Otitis Media ◽  
Mastoid Pneumatization ◽  
Lateral Projection ◽  
Temporal Bones ◽  
End Results

The objective of this study is to correlate in children with chronic secretory otitis media the extent of pneumatization with morphological and functional end results after therapy. For this purpose we examined 82 children and adolescents (147 ears), who 5 to 8 years previously were treated with insertion of ventilating tubes for chronic secretory otitis media. We evaluated the morphological and functional end results with otomicroscopy, pure tone audiometry, tympanometry and stapedial reflex testing. Roentgenograms of the temporal bones in a lateral projection were taken initially in 96 ears and at time of control in 145 ears. We judged the size of the mastoid air cell system by visual estimation and classified the mastoids according to the extent of pneumatization into three groups: large, middle-sized and small (sclerotic). Twenty-five percent of the ears had sclerotic mastoids at time of control. Statistically significant correlations exist between arrested pneumatization (sclerotic mastoids), major morphological changes in the tympanic membranes and unfavorable functional results. Also the correlation between sclerotic mastoids and the number of tube insertions required in the course of the disease is statistically significant. But no correlation can be established between the physical properties of secretions and the extent of pneumatization. Arrest of pneumatization leading to a small mastoid air cell system constitutes an unfavorable prognostic factor for the final outcome of chronic secretory otitis media.

scholarly journals Tympanic membrane changes in experimental acute otitis media and myringotomy

Medicina ◽  
2008 ◽  
Vol 44 (4) ◽  
pp. 313 ◽  
Author(s):  
Giedrė Alzbutienė ◽  
Ann Hermansson ◽  
Per Cayè-Thomasen ◽  
Vytenis Kinduris
Keyword(s):  
Calcium Phosphate ◽  
Haemophilus Influenzae ◽  
Tympanic Membrane ◽  
Otitis Media ◽  
Acute Otitis Media ◽  
Polymorphonuclear Neutrophil ◽  
Sprague Dawley ◽  
Nontypeable Haemophilus Influenzae ◽  
Temporal Bones ◽  
Tympanic Membranes

Objective. The present experimental study explored pathomorphological changes and calcium depositions in the tympanic membrane during experimental acute otitis media caused by nontypeable Haemophilus influenzae in myringotomized and nonmyringotomized ears. Material and methods. A rat model of experimental acute otitis media caused by nontypeable Haemophilus influenzae was employed. Sixteen Sprague-Dawley rats were used. Four days following middle ear inoculation, a bilateral myringotomy was performed in six randomly selected animals. Another group of 10 animals was inoculated only. On days 4, 7, 14, and 28 after inoculation, two animals from each group were sacrificed. The temporal bones were removed and the tympanic membranes were dissected, followed by paraffin embedding. Adjacent sections were stained with PAS-alcian blue for basic histopathological observations and by von Kossa method for determination of calcium phosphate depositions. Results. Particularly intense invasion of polymorphonuclear neutrophil leukocytes was seen on day 4 after inoculation. The highest infiltration of macrophages was observed on day 7. The peak number of lymphocytes was seen on day 14. No difference occurred in the number of polymorphonuclear leukocytes in myringotomized and nonmyringotomized tympanic membranes. The infiltration with lymphocytes and activated macrophages in all parts of the myringotomized tympanic membranes was statistically significantly higher than in the nonmyringotomized animals. The total amount of interstitial calcium phosphate depositions during days 7, 14, and 28 of study was statistically higher in the sections of pars tensa from myringotomized membranes compared to the nonmyringotomized membranes. Conclusion. Nontypeable Haemophilus influenzae-induced acute otitis media and myringotomy provoke more extensive inflammatory reaction with microcalcification in the tympanic membranes.

Pathology of labyrinthine ossification

1991 ◽  
Vol 105 (8) ◽  
pp. 621-624 ◽  
Author(s):  
Christopher deSouza ◽  
Michael M. Paparella ◽  
Pat Schachern ◽  
Tae H. Yoon
Keyword(s):  
Inner Ear ◽  
Otitis Media ◽  
Osseous Tissue ◽  
Scala Tympani ◽  
Fabry’S Disease ◽  
Fabry's Disease ◽  
Basal Turn ◽  
Vascular Compromise ◽  
Temporal Bones

AbstractOssification of the inner ear is the result of multifactorial pathogeneses, such as infection or malignant infiltration, and otosclerosis. Ossification of the innerear spaces is a well documented sequela of suppurative labyrinthitis. In this study of human temporal bones, sections from 14 patients (28 temporal bones)were studied. In additionto the osseous tissue within the inner ear, findings included neoplasms, otosclerosis, otitis media, trauma, and Fabry's disease. We have attempted to correlate these conditions and their influence on the formation of osseous tissue within the spaces of the inner ear. Tympanogenic infection and vascular compromise were found to play an important role in ossification. The scala tympani ofthe basal turn of the cochlea was frequently the site involved.

Statistical Model Estimating the Occurrence of Otitis Media from Temporal Bone Pneumatization

1994 ◽  
Vol 103 (6) ◽  
pp. 469-473 ◽  
Author(s):  
Preben Homøe ◽  
Niels Rasmussen ◽  
Niels Lynnerup ◽  
Lene Theil Skovgaard
Keyword(s):  
Risk Assessment ◽  
Logistic Regression ◽  
Confidence Interval ◽  
Otitis Media ◽  
Logistic Regression Model ◽  
Cell Area ◽  
Temporal Bone Pneumatization ◽  
Middle Ear Disease ◽  
Temporal Bones ◽  
The Relationship

In order to investigate the relationship between the pneumatization of temporal bones and the occurrence of otitis media in Greenlandic Inuit, 36 Greenlandic Inuit were examined by radiography of the temporal bones. The pneumatized cell area was measured planimetrically. All subjects answered a questionnaire on infectious middle ear disease (IMED), and an objective otologic examination was performed. Nine persons of 34 (26%) reported IMED in childhood, and there was IMED reported in all pneumatized areas below 400 mm2. Based on bilateral area measures, a polychotomous logistic regression model was applied. The occurrence of IMED was shown to be associated with smaller areas, and unilateral IMED was associated with pronounced asymmetry. The model has enabled risk assessment, and 8 persons were designated by the model as having had IMED with a sensitivity of 67% (confidence interval 30% to 93%) and a specificity of 92% (confidence interval 74% to 99%). When the model was applied to a historical anthropological Inuit material from 1700 to 1800 AD, 6 of 56 crania were designated as having had IMED. This method has improved the accuracy of estimating the occurrence of IMED in ancient populations.

scholarly journals Cochlear pathology in human temporal bones with otitis media

2009 ◽  
Vol 130 (4) ◽  
pp. 472-476 ◽  
Author(s):  
Shruti Joglekar ◽  
Norimasa Morita ◽  
Sebahattin Cureoglu ◽  
Patricia A. Schachern ◽  
Armin F. Deroee ◽  
...  
Keyword(s):  
Otitis Media ◽  
Cochlear Pathology ◽  
Temporal Bones

Pathology of Chronic Otitis Media

1978 ◽  
Vol 87 (6) ◽  
pp. 749-760 ◽  
Author(s):  
William L. Meyerhoff ◽  
Chong Sun Kim ◽  
Michael M. Paparella
Keyword(s):  
Tympanic Membrane ◽  
Otitis Media ◽  
Granulation Tissue ◽  
Endolymphatic Hydrops ◽  
Chronic Otitis Media ◽  
Tympanic Membrane Perforation ◽  
Membrane Perforation ◽  
Bone Changes ◽  
Subdural Abscess ◽  
Temporal Bones

A review of 800 pathological temporal bones collected from autopsy cases revealed 333 (41.6%) to have some type of otitis media; purulent otitis media (52.5%), serous otitis media (6%), mucoid otitis media (4.5%), and chronic otitis media (36.9%). The 123 temporal bones with chronic otitis media were further studied and found to have granulation tissue, cholesteatoma, cholesterin granuloma, bone changes, and fibrosis. Other findings included tympanic membrane perforation, tympanosclerosis, metaplasia of the epithelium with subepithelial glandular formation, suppuration, labyrinthitis, and evidence of complications of chronic otitis media (meningitis, subdural abscess, brain abscess, petrositis, and endolymphatic hydrops). From this study it was concluded: 1) chronic otitis media occurred quite frequently, from a histological standpoint, in the absence of tympanic membrane perforation; 2) granulation tissue in temporal bones was found much more frequently in chronic otitis media than was cholesteatoma; and 3) complications and sequelae of otitis media tended to occur more commonly secondary to granulation tissue than to cholesteatoma.

R436 – Association Between Chronic Otitis Media and Otosclerosis

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P190-P190
Author(s):  
Sebahattin Cureoglu ◽  
Nomiya Rie ◽  
Nomiya Shigenobu ◽  
Schachern Patricia ◽  
Norimasa Morita ◽  
...  
Keyword(s):  
Clinical Study ◽  
Tympanic Membrane ◽  
Otitis Media ◽  
Chronic Otitis Media ◽  
Tympanic Membrane Perforation ◽  
Membrane Perforation ◽  
Temporal Bones ◽  
Previous Clinical Study

Problem In a previous clinical study, the incidence of chronic otitis media in cases of otosclerosis was reported to be less than that observed in patients without otosclerosis. Histopathologically, we can detect minimal changes such as histological otosclerosis or silent otitis media which are not detected clinically. The purpose of this study is to reveal the association of otosclerosis and chronic otitis media by evaluating human temporal bones, histopathologically. Methods 1235 human temporal bones were reviewed for this study. In order to match patients with otosclerosis, patients with chronic otitis media were limited to 16 to 92 years of age. The incidence of otosclerosis (clinical otosclerosis, histological otosclerosis) and chronic otitis media, either clinical (tympanic membrane perforation) or silent (without perforation) were analyzed. Results There was no statistically difference between the incidence of chronic otitis media in temporal bones with and without otosclerosis. Conclusion The association of chronic otitis media and otosclerosis appears to be a coincidental. Significance The incidence of chronic otitis media in cases of otosclerosis is not less than that observed in cases of chronic otitis media in cases without otosclerosis. Support International Hearing Foundation, Hubbard Foundation, Starkey Foundation.

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