Examination of inner ear structures: a micro-CT study

2022 ◽  
pp. 1-5
Author(s):  
Ferhat Geneci ◽  
Muhammet Bora Uzuner ◽  
Burak Bilecenoğlu ◽  
Bilge İpek Torun ◽  
Kaan Orhan ◽  
...  
Keyword(s):  
Inner Ear ◽  
Micro Ct

scholarly journals Optimization of 3D-Visualization of Micro-Anatomical Structures of the Human Inner Ear in Osmium Tetroxide Contrast Enhanced Micro-CT Scans

2018 ◽  
Vol 12 ◽  
Author(s):  
Thomas van den Boogert ◽  
Marc van Hoof ◽  
Stephan Handschuh ◽  
Rudolf Glueckert ◽  
Nils Guinand ◽  
...  
Keyword(s):  
Inner Ear ◽  
Osmium Tetroxide ◽  
3D Visualization ◽  
Ct Scans ◽  
Micro Ct ◽  
Anatomical Structures ◽  
Contrast Enhanced ◽  
Human Inner Ear

scholarly journals Automatic segmentation of inner ear on CT-scan using auto-context convolutional neural network

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Raabid Hussain ◽  
Alain Lalande ◽  
Kibrom Berihu Girum ◽  
Caroline Guigou ◽  
Alexis Bozorg Grayeli
Keyword(s):  
Neural Network ◽  
Convolutional Neural Network ◽  
Ct Scan ◽  
Inner Ear ◽  
Temporal Bone ◽  
Ct Images ◽  
Patient Specific ◽  
Micro Ct ◽  
Data Set ◽  
3D Vision

AbstractTemporal bone CT-scan is a prerequisite in most surgical procedures concerning the ear such as cochlear implants. The 3D vision of inner ear structures is crucial for diagnostic and surgical preplanning purposes. Since clinical CT-scans are acquired at relatively low resolutions, improved performance can be achieved by registering patient-specific CT images to a high-resolution inner ear model built from accurate 3D segmentations based on micro-CT of human temporal bone specimens. This paper presents a framework based on convolutional neural network for human inner ear segmentation from micro-CT images which can be used to build such a model from an extensive database. The proposed approach employs an auto-context based cascaded 2D U-net architecture with 3D connected component refinement to segment the cochlear scalae, semicircular canals, and the vestibule. The system was formulated on a data set composed of 17 micro-CT from public Hear-EU dataset. A Dice coefficient of 0.90 and Hausdorff distance of 0.74 mm were obtained. The system yielded precise and fast automatic inner-ear segmentations.

scholarly journals Reconstruction of Cochlea Based on Micro-CT and Histological Images of the Human Inner Ear

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Christos Bellos ◽  
George Rigas ◽  
Ioannis F. Spiridon ◽  
Athanasios Bibas ◽  
Dimitra Iliopoulou ◽  
...  
Keyword(s):  
Mathematical Modelling ◽  
Inner Ear ◽  
Basilar Membrane ◽  
Three Dimensional ◽  
Surgical Excision ◽  
Multiscale Model ◽  
Normal Function ◽  
Spiral Ligament ◽  
Micro Ct ◽  
Histological Images

The study of the normal function and pathology of the inner ear has unique difficulties as it is inaccessible during life and, so, conventional techniques of pathologic studies such as biopsy and surgical excision are not feasible, without further impairing function. Mathematical modelling is therefore particularly attractive as a tool in researching the cochlea and its pathology. The first step towards efficient mathematical modelling is the reconstruction of an accurate three dimensional (3D) model of the cochlea that will be presented in this paper. The high quality of the histological images is being exploited in order to extract several sections of the cochlea that are not visible on the micro-CT (mCT) images (i.e., scala media, spiral ligament, and organ of Corti) as well as other important sections (i.e., basilar membrane, Reissner membrane, scala vestibule, and scala tympani). The reconstructed model is being projected in the centerline of the coiled cochlea, extracted from mCT images, and represented in the 3D space. The reconstruction activities are part of the SIFEM project, which will result in the delivery of an infrastructure, semantically interlinking various tools and libraries (i.e., segmentation, reconstruction, and visualization tools) with the clinical knowledge, which is represented by existing data, towards the delivery of a robust multiscale model of the inner ear.

scholarly journals Random walks with statistical shape prior for cochlea and inner ear segmentation in micro-CT images

2017 ◽  
Vol 29 (3) ◽  
pp. 405-414 ◽  
Author(s):  
Esmeralda Ruiz Pujadas ◽  
Gemma Piella ◽  
Hans Martin Kjer ◽  
Miguel Angel González Ballester
Keyword(s):  
Random Walks ◽  
Inner Ear ◽  
Ct Images ◽  
Micro Ct ◽  
Shape Prior ◽  
Statistical Shape

scholarly journals Multimodal Atlas of the Murine Inner Ear: From Embryo to Adult

2021 ◽  
Vol 12 ◽  
Author(s):  
Jean-Paul Bryant ◽  
Vikram Chandrashekhar ◽  
Anthony J. Cappadona ◽  
Pashayar P. Lookian ◽  
Vibhu Chandrashekhar ◽  
...  
Keyword(s):  
High Resolution ◽  
Inner Ear ◽  
3D Visualization ◽  
Early Adulthood ◽  
Cranial Nerves ◽  
Petrous Bone ◽  
Micro Ct ◽  
Complex Anatomy ◽  
Ct And Mri

The inner ear is a complex organ housed within the petrous bone of the skull. Its intimate relationship with the brain enables the transmission of auditory and vestibular signals via cranial nerves. Development of this structure from neural crest begins in utero and continues into early adulthood. However, the anatomy of the murine inner ear has only been well-characterized from early embryogenesis to post-natal day 6. Inner ear and skull base development continue into the post-natal period in mice and early adulthood in humans. Traditional methods used to evaluate the inner ear in animal models, such as histologic sectioning or paint-fill and corrosion, cannot visualize this complex anatomy in situ. Further, as the petrous bone ossifies in the postnatal period, these traditional techniques become increasingly difficult. Advances in modern imaging, including high resolution Micro-CT and MRI, now allow for 3D visualization of the in situ anatomy of organs such as the inner ear. Here, we present a longitudinal atlas of the murine inner ear using high resolution ex vivo Micro-CT and MRI.

scholarly journals Micro CT visualization of silver nanoparticles in the middle and inner ear of rat and transportation pathway after transtympanic injection

2015 ◽  
Vol 13 (1) ◽  
pp. 5 ◽  
Author(s):  
Jing Zou ◽  
Markus Hannula ◽  
Superb Misra ◽  
Hao Feng ◽  
Roberto Labrador ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Inner Ear ◽  
Micro Ct

scholarly journals Micro CT visualization of silver nanoparticles in the middle and inner ear of rat and transportation pathway after transtympanic injection

nano Online ◽  
2016 ◽  
Author(s):  
Jing Zou ◽  
Markus Hannula ◽  
Superb Misra ◽  
Hao Feng ◽  
Roberto Hanoi Labrador ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Inner Ear ◽  
Micro Ct

scholarly journals IE-Map: a novel in-vivo atlas and template of the human inner ear

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Seyed-Ahmad Ahmadi ◽  
Theresa Marie Raiser ◽  
Ria Maxine Rühl ◽  
Virginia Lee Flanagin ◽  
Peter zu Eulenburg
Keyword(s):  
Inner Ear ◽  
Normal Subjects ◽  
Intracranial Volume ◽  
Micro Ct ◽  
Bony Labyrinth ◽  
Non Invasive ◽  
Auditory Organ ◽  
Magnetic Resonance Imaging Mri ◽  
Human Inner Ear

AbstractBrain atlases and templates are core tools in scientific research with increasing importance also in clinical applications. Advances in neuroimaging now allowed us to expand the atlas domain to the vestibular and auditory organ, the inner ear. In this study, we present IE-Map, an in-vivo template and atlas of the human labyrinth derived from multi-modal high-resolution magnetic resonance imaging (MRI) data, in a fully non-invasive manner without any contrast agent or radiation. We reconstructed a common template from 126 inner ears (63 normal subjects) and annotated it with 94 established landmarks and semi-automatic segmentations of all relevant macroscopic vestibular and auditory substructures. We validated the atlas by comparing MRI templates to a novel CT/micro-CT atlas, which we reconstructed from 21 publicly available post-mortem images of the bony labyrinth. Templates in MRI and micro-CT have a high overlap, and several key anatomical measures of the bony labyrinth in IE-Map are in line with micro-CT literature of the inner ear. A quantitative substructural analysis based on the new template, revealed a correlation of labyrinth parameters with total intracranial volume. No effects of gender or laterality were found. We provide the validated templates, atlas segmentations, surface meshes and landmark annotations as open-access material, to provide neuroscience researchers and clinicians in neurology, neurosurgery, and otorhinolaryngology with a widely applicable tool for computational neuro-otology.

Otoconia formation in the chick embryo

1983 ◽  
Vol 41 ◽  
pp. 572-573
Author(s):  
C.D. Fermin ◽  
M. Igarashi
Keyword(s):  
Chick Embryo ◽  
Inner Ear ◽  
Gallus Domesticus ◽  
The Body ◽  
Abnormal Behavior ◽  
Intensive Study ◽  
Basic Fuchsin ◽  
Gestational Period ◽  
Sensory Epithelia ◽  
Transmission Electron

Otoconia are microscopic geometric structures that cover the sensory epithelia of the utricle and saccule (gravitational receptors) of mammals, and the lagena macula of birds. The importance of otoconia for maintanance of the body balance is evidenced by the abnormal behavior of species with genetic defects of otolith. Although a few reports have dealt with otoconia formation, some basic questions remain unanswered. The chick embryo is desirable for studying otoconial formation because its inner ear structures are easily accessible, and its gestational period is short (21 days of incubation).The results described here are part of an intensive study intended to examine the morphogenesis of the otoconia in the chick embryo (Gallus- domesticus) inner ear. We used chick embryos from the 4th day of incubation until hatching, and examined the specimens with light (LM) and transmission electron microscopy (TEM). The embryos were decapitated, and fixed by immersion with 3% cold glutaraldehyde. The ears and their parts were dissected out under the microscope; no decalcification was used. For LM, the ears were embedded in JB-4 plastic, cut serially at 5 micra and stained with 0.2% toluidine blue and 0.1% basic fuchsin in 25% alcohol.

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