Depot Neuroleptic Medication and Serum Levels by Radioreceptor Assay: Prolactin Concentration, Electrocardiogram Abnormalities and Six-Month Outcome

1987 ◽  
Vol 21 (3) ◽  
pp. 327-338
Author(s):  
John Turbott ◽  
John Villiger ◽  
Lynley Hunter
Keyword(s):  
Serum Levels ◽  
Radioreceptor Assay ◽  
Clinical State ◽  
Serum Prolactin ◽  
Chronic Patients ◽  
Fluphenazine Decanoate ◽  
Schizophrenic Patients ◽  
Depot Neuroleptic ◽  
Electrocardiogram Ecg ◽  
Flupenthixol Decanoate

Twenty-six chronic schizophrenic patients on well-established depot neuroleptic regimes with stable doses (16 on fluphenazine decanoate, 10 on flupenthixol decanoate) had serum neuroleptic levels measured by radioreceptor assay (RRA) and were followed for six months. The serum prolactin (PRL) concentration and resting electrocardiogram (ECG) were also taken at the beginning of the study period. Correlations had previously been noted between RRA measured neuroleptic levels and outcome in both acute and chronic patients on oral medication. However, in this study of depot medication no significant correlations were found between serum neuroleptic concentration, serum prolactin concentration and the clinical state or outcome. The prevalence (33%) and type of ECG abnormality observed was similar to that previously reported.

Neuroleptic Serum Levels Measured by Radioreceptor Assay in Patients Receiving Intramuscular Depot Neuroleptics Some Preliminary Findings

1985 ◽  
Vol 146 (4) ◽  
pp. 439-442 ◽  
Author(s):  
John Turbott ◽  
John Villiger ◽  
Lynley Hunter
Keyword(s):  
Blood Level ◽  
Serum Levels ◽  
Radioreceptor Assay ◽  
Time Interval ◽  
Fluphenazine Decanoate ◽  
Wide Range ◽  
Schizophrenic Patients ◽  
Depot Neuroleptic ◽  
Flupenthixol Decanoate ◽  
Inter Assay Variation

SummaryTwenty-six chronic schizophrenic patients on well established depot neuroleptic regimes with stable doses (16 on fluphenazine decanoate, ten on flupenthixol decanoate) had serum neuroleptic levels measured by a radioreceptor assay (RRA) method. The assay was sufficiently sensitive to measure serum levels in all cases, with acceptable levels of inter-assay variation. Blood level measurements were repeated on two occasions, at the same time interval from the last injection, in 18 patients (11 on fluphenazine decanoate, seven on flupenthixol decanoate) and remained reasonably stable in most cases, although others showed a wider variation. Despite a wide range of doses (× 32 fluphenazine decanoate, × 21 flupenthixol decanoate) the serum levels fell in a remarkably narrow range (× 4, × 6). There was a significant correlation between dose and blood level for flupenthixol decanoate, but not for fluphenazine decanoate.

Effects of Risperidone and Aripiprazole on Serum Levels of Prolactin, Testosterone and Estradiol in Female Patients with Schizophrenia

Drug Research ◽  
2018 ◽  
Vol 68 (07) ◽  
pp. 410-414 ◽  
Author(s):  
Xiao-Jia Jiang ◽  
Fu-Xi Wu ◽  
Jian-Ping Zhang ◽  
Lei Shi ◽  
Jin-Qing Hu ◽  
...  
Keyword(s):  
Prospective Study ◽  
Serum Testosterone ◽  
Serum Levels ◽  
Study Data ◽  
Serum Prolactin ◽  
Female Patients ◽  
Schizophrenic Patients ◽  
High Level ◽  
Estradiol Levels ◽  
Risperidone Treatment

Abstract Objective To evaluate the effects of treatment with risperidone and aripiprazole on serum prolactin, testosterone and estradiol levels in female patients with schizophrenia in China. Methods In the retrospective study, Data were collected and included prolactin, testosterone and estradiol levels of 30 female patients with risperidone monotherapy. In the prospective study, Another 30 female schizophrenic patients were randomized to receive risperidone or adjunctive aripiprazole for six weeks. Serum prolactin, testosterone and estradiol levels were measured. Results Serum prolactin, testosterone and estradiol levels in both studies were significantly decreased after risperidone treatment compared with baseline (P<0.05), and prolactin levels remained at a high level. Serum prolactin levels in the adjunctive aripiprazole group were significantly decreased after treatment compared with baseline in the prospective study (P<0.05). Doses of 5 mg and 10 mg of adjunctive aripiprazole achieved the same efficacy at the end of treatment. Conclusions Risperidone treatment decreased serum testosterone and estradiol levels. Adjunctive aripiprazole relieved hyperprolactinemia, but had no effect on testosterone or estradiol levels. Adjunctive aripiprazole at a dose of 5 mg is recommended for clinical use.

Interactions between Procyclidine and Neuroleptic Drugs

1986 ◽  
Vol 149 (6) ◽  
pp. 726-733 ◽  
Author(s):  
J. S. Bamrah ◽  
V. Kumar ◽  
J. Krska ◽  
S. D. Soni
Keyword(s):  
Clinical Relevance ◽  
Serum Levels ◽  
Serum Prolactin ◽  
Neuroleptic Drugs ◽  
Fluphenazine Decanoate

Procyclidine was administered to 25 chronic psychotic inpatients, stabilised on chlorpromazine, haloperidol or fluphenazine decanoate injection. We observed a significant reduction in mean serum levels of all three neuroleptic drugs which was reversed on stopping procyclidine and was Inversely correlated with mean serum procyclidine levels. No significant alterations occurred on the BPRS scores or in serum prolactin levels throughout the study In any of the three groups. Possible mechanisms of this interaction and its clinical relevance are discussed.

Comparison of Antipsychotic Depot Injections in the Maintenance Treatment of Schizophrenia

1976 ◽  
Vol 129 (5) ◽  
pp. 476-481 ◽  
Author(s):  
M. W. P. Carney ◽  
B. F. Sheffield
Keyword(s):  
Movement Disorder ◽  
Maintenance Treatment ◽  
Severe Depression ◽  
The Other ◽  
Fluphenazine Decanoate ◽  
Schizophrenic Patients ◽  
Extrapyramidal Effects ◽  
Depot Injections ◽  
Flupenthixol Decanoate

Summary122 Schizophrenic patients treated with injections of fluphenazine ethanate, 97 with fluphenazine decanoate and 199 with flupenthixol decanoate were followed up for mean times of 41, 33 and 21 months respectively. Their progress was compared by examining reasons for discontinuing injections and outcome in three separate groups defined according to first preparation given; relating the events causing patients to discontinue injections or be readmitted to patient-months spent on each drug; and analysing reasons for inter-drug transfers 43 per cent, 24 per cent and 23 per cent respectively of these three groups of patients discontinued the injections. Severe extrapyramidal effects were most frequent with fluphenazine ethanate, intermediate with fluphenazine decanote, and least frequent with flupenthixol. Lack of cooperation was rather more frequent with flupenthixol than with the other drugs. Severe depression occurred with all three. More patients on fluphenazine injections were transferred for any reason to flupenthixol than vice-versa. A case of ‘irreversible’ movement disorder was seen with each preparation. It is suggested that current maintenance doses of flupenthixol decanoate are too low.

Neuroleptic Serum Levels Measured by Radioreceptor Assay and Clinical Response in Schizophrenic Patients

1981 ◽  
Vol 169 (1) ◽  
pp. 60-63 ◽  
Author(s):  
LARRY E. TUNE ◽  
IAN CREESE ◽  
J. RAYMOND DEPAULO ◽  
PHILLIP R. SLAVNEY ◽  
SOLOMON H. SNYDER
Keyword(s):  
Clinical Response ◽  
Serum Levels ◽  
Radioreceptor Assay ◽  
Schizophrenic Patients

scholarly journals Determination of Chlorpromazine in Serum by Radioreceptor Assay and HPLC

1986 ◽  
Vol 23 (3) ◽  
pp. 340-345 ◽  
Author(s):  
J Krska ◽  
G M Addison ◽  
S D Soni
Keyword(s):  
Parent Drug ◽  
Hplc Method ◽  
Radioreceptor Assay ◽  
Serum Prolactin ◽  
Active Metabolites ◽  
Serum Prolactin Level ◽  
Serum Samples ◽  
Blocking Activity ◽  
Schizophrenic Patients

A radioreceptor assay for chlorpromazine in serum, which is based on binding to dopamine receptors, is described. This method has been postulated to measure all active metabolites as well as the parent drug. We have compared this method with an HPLC method for chlorpromazine. Dopamine-blocking activity, measured in serum samples from schizophrenic patients receiving chlorpromazine, was 1·85–9·1 times higher than serum chlorpromazine level measured by HPLC. The correlation between the two methods was 0·75. Dopamine-blocking activity was related more closely to dose of drug and to serum prolactin level than was serum chlorpromazine level measured by HPLC.

scholarly journals Amino Acid and Acylcarnitine Levels in Chronic Patients with Schizophrenia: A Preliminary Study

Metabolites ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 34
Author(s):  
Irina A. Mednova ◽  
Alexander A. Chernonosov ◽  
Marat F. Kasakin ◽  
Elena G. Kornetova ◽  
Arkadiy V. Semke ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Amino Acids ◽  
Amino Acid ◽  
Chronic Schizophrenia ◽  
Integrated Approach ◽  
Serum Levels ◽  
Tandem Mass ◽  
Chronic Patients ◽  
Healthy Donors ◽  
Preliminary Study

Amino acids and acylcarnitines play an important role as substrates and intermediate products in most of pathways involved in schizophrenia development such as mitochondrial dysfunction, inflammation, lipid oxidation, DNA damage, oxidative stress, and apoptosis. It seems relevant to use an integrated approach with ‘omics’ technology to study their contribution. The aim of our study was to investigate serum amino acid and acylcarnitine levels in antipsychotics-treated patients with chronic schizophrenia compared with healthy donors. We measured serum levels of 15 amino acids and 30 acylcarnitines in 37 patients with schizophrenia and 36 healthy donors by means of tandem mass spectrometry. In summary, patients with chronic schizophrenia had an altered concentration of a few amino acids and acylcarnitines in comparison to the healthy probands. Further research is needed to assess and understand the identified changes.

scholarly journals Serum levels of Cadmium, Calcium, Lead and Iron in Schizophrenic Patients

1970 ◽  
Vol 5 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Pinky Karim ◽  
Md. Iqbal Hossain ◽  
AFM Nazmus Sadat ◽  
Zabun Nahar ◽  
Md. Khalid Hossain ◽  
...  
Keyword(s):  
Trace Elements ◽  
Serum Concentration ◽  
Prognostic Significance ◽  
Serum Levels ◽  
Schizophrenic Disorder ◽  
Flame Atomic Absorption Spectroscopy ◽  
Flame Atomic Absorption ◽  
Schizophrenic Patients ◽  
Calcium Lead ◽  
Exact Correlation

The serum concentration of cadmium (Cd), lead (Pb), calcium (Ca) and iron (Fe) in 30 schizophrenic patients and 30 normal healthy subjects were analyzed by flame atomic absorption spectroscopy. The concentrations of Cd, Pb and Ca in schizophrenic disorder patients was not increased significantly (P > 0.05) compared to that of the cohort controls. But the concentration of Fe in schizophrenic patients was significantly different from that of the cohort control (p < 0.000). The change in serum concentration of different trace elements may have some prognostic significance for the diagnosis of schizophrenic disorder. However further work is suggested to examine the exact correlation between trace elements level and the degree of disorder in schizophrenic patients. Key words: Schizophrenic patients, trace elements, clinical significance Dhaka Univ. J. Pharm. Sci. Vol.5(1-2) 2006 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

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