Effects of Risperidone and Aripiprazole on Serum Levels of Prolactin, Testosterone and Estradiol in Female Patients with Schizophrenia

Drug Research ◽  
2018 ◽  
Vol 68 (07) ◽  
pp. 410-414 ◽  
Author(s):  
Xiao-Jia Jiang ◽  
Fu-Xi Wu ◽  
Jian-Ping Zhang ◽  
Lei Shi ◽  
Jin-Qing Hu ◽  
...  
Keyword(s):  
Prospective Study ◽  
Serum Testosterone ◽  
Serum Levels ◽  
Study Data ◽  
Serum Prolactin ◽  
Female Patients ◽  
Schizophrenic Patients ◽  
High Level ◽  
Estradiol Levels ◽  
Risperidone Treatment

Abstract Objective To evaluate the effects of treatment with risperidone and aripiprazole on serum prolactin, testosterone and estradiol levels in female patients with schizophrenia in China. Methods In the retrospective study, Data were collected and included prolactin, testosterone and estradiol levels of 30 female patients with risperidone monotherapy. In the prospective study, Another 30 female schizophrenic patients were randomized to receive risperidone or adjunctive aripiprazole for six weeks. Serum prolactin, testosterone and estradiol levels were measured. Results Serum prolactin, testosterone and estradiol levels in both studies were significantly decreased after risperidone treatment compared with baseline (P<0.05), and prolactin levels remained at a high level. Serum prolactin levels in the adjunctive aripiprazole group were significantly decreased after treatment compared with baseline in the prospective study (P<0.05). Doses of 5 mg and 10 mg of adjunctive aripiprazole achieved the same efficacy at the end of treatment. Conclusions Risperidone treatment decreased serum testosterone and estradiol levels. Adjunctive aripiprazole relieved hyperprolactinemia, but had no effect on testosterone or estradiol levels. Adjunctive aripiprazole at a dose of 5 mg is recommended for clinical use.

ANNUAL RHYTHMS OF LUTEINIZING HORMONE, FOLLICLE-STIMULATING HORMONE, PROLACTIN AND TESTOSTERONE IN THE SERUM OF MALE RHESUS MONKEYS

1979 ◽  
Vol 83 (2) ◽  
pp. 131-139 ◽  
Author(s):  
W. BECK ◽  
W. WUTTKE
Keyword(s):  
Rhesus Monkeys ◽  
Serum Testosterone ◽  
Serum Levels ◽  
Serum Prolactin ◽  
First Year ◽  
Thyrotrophin Releasing Hormone ◽  
Testosterone Levels ◽  
Serum Lh ◽  
June July ◽  
Male Rhesus

Six male rhesus monkeys were kept under rigidly controlled conditions for 1–2 years. During August of the first year a thyrotrophin releasing hormone (TRH) test was performed on each of the monkeys by giving 10 μg TRH as a bolus injection. Significantly increased serum prolactin levels occurred 15 min after the injection. After a training period of 2 months, during which blood samples were collected every other day by puncture of the saphenous vein, blood was collected three times a week for 14 months. Serum levels of prolactin, LH, FSH and testosterone were measured by radioimmunoassay. Mean serum prolactin levels increased significantly during June, July and August in all six animals. Peak levels were observed in August and September and then levels declined gradually to reach a minimum in April and May. Mean serum testosterone levels closely paralleled the annual pattern of prolactin. Mean serum LH levels significantly decreased during the time when mean serum prolactin and testosterone levels were increasing and they increased again at the time of decreasing mean prolactin levels, i.e. mean serum LH and prolactin were negatively correlated. In individual monkeys, however, a rigid negative correlation between serum prolactin and LH could not be demonstrated. Mean serum FSH levels did not change significantly.

Bromocriptin and Cabergolin in Treatment of Hyperprolactinemia in Schizophrenia and Schizoaffective Disorder

2011 ◽  
Vol 26 (S2) ◽  
pp. 1395-1395
Author(s):  
L. Gorobets ◽  
V. Bulanov
Keyword(s):  
Blood Serum ◽  
Schizoaffective Disorder ◽  
Prolactin Level ◽  
Comparative Assessment ◽  
Serum Prolactin ◽  
Serum Prolactin Level ◽  
Female Patients ◽  
Long Period ◽  
Immunoenzyme Method ◽  
High Level

IntroductionCorrection of the syndrome of hyperprolactinemia is very important problem of psychopharmacotherapy.AimsComparative assessment of efficacy by bromocriptin and cabergolin action in syndrome of hyperprolactinemia in patients with schizophrenia and schizoaffective disorder.Methods120 female patients with diagnosis of schizophrenia (86) and schizoaffective disorder (34) were treated for a long period with risperidon; all of them suffered of hyperprolactinemia. Bromocriptin and cabergolin were used for the treatment of hyperprolactinemia. All patients were separated for 2 groups: patients of the 1st group (n = 64) were treated with bromocriptin (5 mg daily/2 months), patients of the 2nd group (n = 56) - with cabergolin (5 mg weekly/2 months). The level of prolactin was estimated in blood serum using immunoenzyme method.ResultsIn the 1st group 48 patients (75%) were responders: prolactin level decreased from 1997 ± 504 m ME/I to 1125 ± 293 m ME/I (p ≤ 0.05) and in 16 (25%) nonresponders prolactin level did not change - 2165 ± 606 m ME/I before and 2190 ± 441 m ME/I after the treatment (p ≥ 0.05). In the 2nd group 48 patients were responders (85.7%) and serum prolactin level was reduced in the range of 30-75% from 2294 ± 634 mME/l to 1109 ± 240 mME/l (p ≤ 0.05). In the nonresponders (8 patients; 14.3%) changes of serum prolactin were insignificant (2514 ± 578 mME/l/ before and 2084 ± 451 mME/l after the therapy; p ≥ 0.05).ConclusionsInvestigation has shown a high level of efficiency of cabergolin (dostinex) and bromocriptin in correction of hyperprolactinemia.

scholarly journals Low serum levels of dehydroepiandrosterone sulfate and testosterone in Albanian female patients with allergic disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Violeta Lokaj-Berisha ◽  
Besa Gacaferri Lumezi ◽  
Naser Berisha
Keyword(s):  
Serum Testosterone ◽  
Allergic Diseases ◽  
Serum Levels ◽  
Dehydroepiandrosterone Sulfate ◽  
Total Serum ◽  
Control Group ◽  
Total Testosterone ◽  
Serum Concentrations ◽  
Female Patients ◽  
Subject Selection

AbstractEvidence from several unrelated animal models and some studies conducted in humans, points to the immunomodulatory effects of androgens on various components of the immune system, especially on allergic disorders. This study evaluated the serum concentrations of sex hormones in women with allergy. For this purpose, blood samples were obtained from 78 participants in order to detect serum IgE concentrations, total testosterone, estradiol, progesterone, and DHEA-S. The majority of the subjects (54) in the study were consecutive patients with doctor-diagnosed allergic pathologies: 32 with allergic rhinitis, 10 with asthma and rhinitis, and 12 with skin allergies. In addition, 24 healthy volunteers were included in the research as the control group. The average age of the subjects was 32.54 years (SD ± 11.08 years, range between 4–59 years). All participants stated that they had not used any medical treatment to alleviate any of their symptoms prior to taking part in the research. They all underwent skin-prick tests for common aero-allergens, which was used as criterion for subject selection. Hence, the subjects were selected if they reacted positively to at least one aero-allergen. Their height and weight were measured in order to calculate the BMI. As a result, statistically significant differences between controls and allergic women in serum concentrations of androgens (testosterone, p = 0.0017; DHEA-S, p = 0.04) were found, which lead to the conclusion that the concentration of total serum testosterone and DHEA-S was lower in female patients with allergic diseases compared to controls.

Serum concentrations of testosterone throughout pregnancy in rats

1982 ◽  
Vol 94 (1) ◽  
pp. 21-27 ◽  
Author(s):  
R. S. Bridges ◽  
R. B. Todd ◽  
C. M. Logue
Keyword(s):  
Post Partum ◽  
Late Pregnancy ◽  
Serum Testosterone ◽  
Serum Levels ◽  
Diurnal Variations ◽  
Serum Prolactin ◽  
Serum Concentrations ◽  
Pregnant Rats ◽  
Pregnant Rat ◽  
Microcolumn Chromatography

Testosterone concentrations in serum of rats bled throughout pregnancy and post partum were measured using Celite microcolumn chromatography and a radioimmunoassay for testosterone. Mean serum levels of testosterone ranged from about 170 to 340 pmol/l during the first 10 days of pregnancy. Significant increases in concentrations of testosterone in serum of pregnant rats were found on days 12, 15 and 18 of gestation. The highest testosterone concentrations occurred on days 18 and 20 of pregnancy when mean levels were 3228 and 3685 pmol/l respectively. Testosterone levels declined before parturition on day 22 (mean = 1449 pmol/l and declined further after parturition (mean = 315 pmol/l). In order to determine whether serum testosterone concentrations varied during the day in the pregnant rat, samples were collected at 6-h intervals on days 6–7 and 14–15 of gestation. Diurnal variations in serum testosterone concentrations were not evident during early or late pregnancy, unlike the rhythmic changes in serum prolactin levels found at these times during early pregnancy. The possible sources of the increased titres of serum testosterone during the second part of gestation in rats are discussed.

scholarly journals Evaluation of Serum Testosterone, Progesterone, Seminal Antisperm Antibody, and Fructose Levels among Jordanian Males with a History of Infertility

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
Hala I. Al-Daghistani ◽  
Abdul-Wahab R. Hamad ◽  
Muna Abdel-Dayem ◽  
Mohammad Al-Swaifi ◽  
Mohammad Abu Zaid
Keyword(s):  
Sperm Motility ◽  
Seminal Plasma ◽  
Seminal Fluid ◽  
Inverse Correlation ◽  
Serum Testosterone ◽  
Serum Levels ◽  
Fertility Treatment ◽  
Mean Values ◽  
Sperm Antibodies ◽  
High Level

Due to the biochemical complexity of seminal fluid, we attempt to study the possible correlation between fructose, which is secreted under the effect of androgen hormone, and autoimmunity, which might play a role in varicocele associated infertility, in reducing sperm motility. Seminal fructose, antisperm antibodies (ASAs) and blood steroids hormones (testosterone and progesterone) levels were measured in 66 infertile males with varicocele and 84 without varicocele referred for fertility treatment. Seminal analysis was performed with biochemical measurements of seminal fructose and mixed agglutination reaction (MAR) for ASA. Serum levels of progesterone and testosterone were estimated using a competitive chemoluminescent enzyme immunoassay. The mean values for serum testosterone were380.74±24.331,365.9±16.55, and367.5±21.8 ng/dl, progesterone0.325±0.243,0.341±0.022, and0.357  ±  0.0306 ng/ml, and seminal plasma fructose359.6  ±  26.75,315.6  ±  13.08, and332.08  ±  24.38 mg/dl in males with varicocele, without varicocele, and fertile males, respectively. A significant high level of testosterone was observed within varicocele group (P=.001). This result showed that testosterone may play a role as an infertility determinant in subjects with varicocele. ASA was detected in 18 (26.47%) of cases with varicocele, 20 (38.46%) without varicocele, and in 16 (32.0%) fertile men. Cases with ASAs associated with low sperm motility morphology. An inverse correlation between sperm-bound antibodies and viscosity has been shown (P=.017). ASA showed some significant inverse relations with ages, durations of infertility, and viscosity (P<.05). In addition, a significant correlation was observed between ASA positive seminal plasma and testosterone concentration among infertile cases (with or without varicocele) and fertile (P<.05). Our results suggest a relationship between testicular steroid hormone levels with autoimmunity and sperm antibodies which influence the motility of ejaculated spermatozoa among Jordanian infertile males.

Depot Neuroleptic Medication and Serum Levels by Radioreceptor Assay: Prolactin Concentration, Electrocardiogram Abnormalities and Six-Month Outcome

1987 ◽  
Vol 21 (3) ◽  
pp. 327-338
Author(s):  
John Turbott ◽  
John Villiger ◽  
Lynley Hunter
Keyword(s):  
Serum Levels ◽  
Radioreceptor Assay ◽  
Clinical State ◽  
Serum Prolactin ◽  
Chronic Patients ◽  
Fluphenazine Decanoate ◽  
Schizophrenic Patients ◽  
Depot Neuroleptic ◽  
Electrocardiogram Ecg ◽  
Flupenthixol Decanoate

Twenty-six chronic schizophrenic patients on well-established depot neuroleptic regimes with stable doses (16 on fluphenazine decanoate, 10 on flupenthixol decanoate) had serum neuroleptic levels measured by radioreceptor assay (RRA) and were followed for six months. The serum prolactin (PRL) concentration and resting electrocardiogram (ECG) were also taken at the beginning of the study period. Correlations had previously been noted between RRA measured neuroleptic levels and outcome in both acute and chronic patients on oral medication. However, in this study of depot medication no significant correlations were found between serum neuroleptic concentration, serum prolactin concentration and the clinical state or outcome. The prevalence (33%) and type of ECG abnormality observed was similar to that previously reported.

scholarly journals MON-272 Clinical Relevance of Serum Prolactin Levels to Inflammatory Reaction in Male Patients

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Koichiro Yamamoto ◽  
Yoshihisa Hanayama ◽  
Kou Hasegawa ◽  
Miho Yasuda ◽  
Kazuki Tokumasu ◽  
...  
Keyword(s):  
Serum Albumin ◽  
General Medicine ◽  
Serum Levels ◽  
Albumin Level ◽  
Study Data ◽  
Serum Prolactin ◽  
Bone Homeostasis ◽  
Inflammatory Status ◽  
Male Patients ◽  
Clinical Records

Abstract PRL is a polypeptide hormone that is, in phylogeny, well conserved but elicits various species-dependent functions. PRL is related to the regulation of osmotic pressure in fish and amphibians, fat retention in reptiles and birds, and glucose-lipid metabolism, bone homeostasis and development of the mammary gland in mammals. In humans, PRL secretion is regulated in an inhibitory manner by dopaminergic neurons that project from the hypothalamus to PRL-producing cells in the anterior pituitary gland. Since dopaminergic actions are mainly mediated by D2R, various agents that bind D2R can affect serum PRL levels. In the clinical aspect, hyperprolactinemia is considered in cases with galactorrhea, infertility and sexual dysfunction. Other causes of hyperprolactinemia include hypothyroidism, chronic kidney disease and pregnancy. Also, PRL receptors have been considered as therapeutic targets for some cancers and autoimmune diseases. Given that several pathophysiological functions related to PRL have been recently uncovered, the utility of measuring serum PRL levels could be more widely applicable for a clinical setting. We therefore attempted to reveal the relevance of PRL levels to various clinical parameters in patients who visited a general medicine department. We reviewed medical records of 353 patients whose serum PRL levels were measured in our department during the period from 2016 to 2018. Patients lacking detailed clinical records (n=194) and patients taking medications that affect D2R (n=19) were excluded from this study. Data were analyzed for 140 patients (42 males, aged 49 ± 18 years; 98 females, 45 ± 19 years) in whom various pain and general fatigue were major symptoms at the first visit and in whom hypertension and dyslipidemia were frequently seen in past histories. Average PRL levels were significantly lower in males than in females. The median PRL level in males was 6.5 ng/ml (IQR: 4.2–10.3) ng/ml and that in females was 8.1 ng/ml (5.9–12.9). Patients were divided into two groups depending on whether PRL levels were higher than 10 ng/ml. The group of males with relatively high PRL levels (≥10 ng/ml) had significantly lower levels of serum albumin and higher levels of serum LDH. Of note, there were significant correlations of male PRL levels to erythrocyte sedimentation rate (ESR) (r=0.6), serum LDH (r=0.4) and albumin level (r=-0.5), and TSH/FT4 ratio (r=0.5). On the other hand, female PRL levels were negatively correlated to age (r=-0.2) and serum levels of FSH (r=-0.3) and positively correlated to serum levels of GH (r=0.3). Collectively, the results revealed that PRL levels had gender-specific relevance to various clinical factors. It is notable that PRL levels in males were related to inflammatory status shown by high ESR and low serum albumin and were also associated with a hypothyroid condition.

scholarly journals Decreased serum prolactin levels accompanied by infection in patients with symptomatology of spontaneous miscarriage

2002 ◽  
Vol 55 (7-8) ◽  
pp. 315-320
Author(s):  
Anita Mitreski ◽  
Gordana Radeka
Keyword(s):  
Bacterial Infections ◽  
Serum Levels ◽  
Serum Prolactin ◽  
Genital Infection ◽  
Serum Estradiol ◽  
Vaginal Infection ◽  
Dramatic Decrease ◽  
Estradiol Levels

Introduction Previous research indicates that intraovular infections result in dramatic decrease of prolactin serum levels during pregnancy. The aim of this study was to assess biochemical aspects of pregnancy, including determination of serum prolactin levels in patients with infection. Material and methods The evaluation included patients with symptoms of imminent miscarriage and present, or absent signs of vaginal infection, as well as patients with uncompromised pregnancies, as controls. Results Serum estradiol levels, progesterone and prolactin were decreased in patients with bacterial infections. Discussion The role of prolactin in regulation of pregnancy was discussed, as well as its interactions with other regulatory hormones of pregnancy. Conclusion Serum prolactin levels were decreased (17.68%) in patients with symptoms of imminent miscarriage and current lower genital infection.

Prolactin in Cluster Headache: Diurnal Secretion, Response to Thyrotropin-Releasing Hormone, and Relation to Sex Steroids and Gonadotropins

Cephalalgia ◽  
1987 ◽  
Vol 7 (1) ◽  
pp. 43-54 ◽  
Author(s):  
Elisabet Waldenlind ◽  
Sven A Gustafsson
Keyword(s):  
Cluster Headache ◽  
Clinical Remission ◽  
Serum Levels ◽  
Thyrotropin Releasing Hormone ◽  
Serum Prolactin ◽  
Releasing Hormone ◽  
Female Patients ◽  
Male Patients ◽  
Altered Regulation ◽  
Active Cluster

The diurnal rhythmicity of serum prolactin (PRL) and the PRL and thyrotropin (TSH) response to thyrotropin-releasing hormone (TRH) were studied in 31 cluster headache patients (4 chronic cases) and 14 healthy controls. Sixteen of the patients were studied both during clinical remission and headache periods. In males the nocturnal PRL peak was blunted during remissions as compared with that in cluster periods and that in control individuals. The 24-h mean PRL levels were lower during remission and cluster periods than in the controls. There were no significant differences in the PRL levels between female patients and controls. Headache attacks were often associated with increases of serum PRL levels. The PRL reponse to TRH was lower in the female patients but not in the male patients as compared with controls. The maximum testosterone levels were lower during cluster periods than during clinical remission but not when compared with controls. Serum levels of luteinizing hormone, follicle-stimulating hormone, progesterone, estradiol, T3, T4, and TSH did not differ between patients and controls. The results suggest an altered regulation of PRL secretion not only during active cluster periods but also during symptom-free intervals. The possible influence of sleep, estradiol, testosterone, medication, pain, and serotoninergic and dopaminergic mechanisms are discussed.

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