scholarly journals Serum levels of Cadmium, Calcium, Lead and Iron in Schizophrenic Patients

1970 ◽  
Vol 5 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Pinky Karim ◽  
Md. Iqbal Hossain ◽  
AFM Nazmus Sadat ◽  
Zabun Nahar ◽  
Md. Khalid Hossain ◽  
...  
Keyword(s):  
Trace Elements ◽  
Serum Concentration ◽  
Prognostic Significance ◽  
Serum Levels ◽  
Schizophrenic Disorder ◽  
Flame Atomic Absorption Spectroscopy ◽  
Flame Atomic Absorption ◽  
Schizophrenic Patients ◽  
Calcium Lead ◽  
Exact Correlation

The serum concentration of cadmium (Cd), lead (Pb), calcium (Ca) and iron (Fe) in 30 schizophrenic patients and 30 normal healthy subjects were analyzed by flame atomic absorption spectroscopy. The concentrations of Cd, Pb and Ca in schizophrenic disorder patients was not increased significantly (P > 0.05) compared to that of the cohort controls. But the concentration of Fe in schizophrenic patients was significantly different from that of the cohort control (p < 0.000). The change in serum concentration of different trace elements may have some prognostic significance for the diagnosis of schizophrenic disorder. However further work is suggested to examine the exact correlation between trace elements level and the degree of disorder in schizophrenic patients. Key words: Schizophrenic patients, trace elements, clinical significance Dhaka Univ. J. Pharm. Sci. Vol.5(1-2) 2006 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

scholarly journals Serum Trace Elements in Manic Patients

1970 ◽  
Vol 4 (1) ◽  
Author(s):  
Md Abu Baker ◽  
AFM Nazmus Sadat ◽  
Md Lutfor Rahman ◽  
MMA Shalahuddin Qusar ◽  
SM Imamul Huq ◽  
...  
Keyword(s):  
Trace Elements ◽  
Serum Concentration ◽  
Prognostic Significance ◽  
Flame Atomic Absorption Spectroscopy ◽  
Flame Atomic Absorption ◽  
Human Volunteers ◽  
Copper Manganese ◽  
Serum Trace Elements ◽  
Manic Patients ◽  
Exact Correlation

The serum concentration of zinc, copper, manganese and lead in 30 manic patients and 30 human volunteers were determined by flame atomic absorption spectroscopy. It was observed that the concentration of zinc in manic patients increased significantly (P < 0.05), where as the concentrations of copper, manganese and lead were found to be within the limit (P > 0.05). These concentrations of different trace elements may have some prognostic significance for the diagnosis of manic patients, but more work is suggested to find out the exact correlation between trace elements level & the degree of disorder in manic patients. Key words: Mania, trace elements, serum etc. Dhaka Univ. J. Pharm. Sci. Vol.4(1) 2005 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

scholarly journals Toxicity, Deficiency and Dysmetabolism of Trace Elements in Ghanaian Clinically Stable Schizophrenics

2014 ◽  
Vol 2 (2) ◽  
pp. 293-298
Author(s):  
George A. Asare ◽  
Ruth Tetteh ◽  
Elsie Amedonu ◽  
Bernice Asiedu ◽  
Derek Doku
Keyword(s):  
Trace Elements ◽  
Random Sampling ◽  
Test Group ◽  
Psychiatric Hospitals ◽  
Simple Random Sampling ◽  
Serum Levels ◽  
Healthy Controls ◽  
Flame Atomic Absorption Spectroscopy ◽  
Flame Atomic Absorption ◽  
Schizophrenic Patients

AIM: The purpose of the study was to determine the levels of Copper (Cu), selenium (Se), Zinc (Zn), Lead (Pb) and Lithium (Li) in patients in Accra and Pantang Psychiatric Hospitals in Ghana since no data exist.SUBJECTS AND METHODS: Simple random sampling of age-matched subjects was used to recruit 81 schizophrenics and 25 mentally healthy controls in 2012. Serum levels of Cu, Se, Zn, Pb and Li were determined by flame atomic absorption spectroscopy (FAAS). RESULTS: Mean levels were as follows: Cut 766 ± 250 µg/L and Cuc 855 ± 270 µg/L (p = 0.168). Set 149 ± 72 µg/L and Sec 108 ± 61 µg/L (p=0.009). Znt 702 ± 438 µg/L and Znc 1007 ± 593 µg/L (p = 0.028). Pbt 1.38 ± 0.05 µg/L and Pbc 0.10 ± 0.05 µg/L (p = 0.000). Li levels for the test group (Lit) was 4077 ± 2567 µg/L, whiles that of the controls was undetectable < 0.02 µg/L. Se, Pb and Li levels were significantly higher in schizophrenic patients compared to controls. While Zn and Cu levels were lower in the same group.CONCLUSION: Trace elements dysmetabolism exist among Ghanaian schizophrenics and monitoring is essential to avoid the adverse effects of metal overload or deficiency.

scholarly journals Analysis of serum trace elements, macro-minerals, antioxidants, malondialdehyde and immunoglobulins in seborrheic dermatitis patients: A case-control investigation

2020 ◽  
Author(s):  
Ishrat Jahan ◽  
Md. Rabiul Islam ◽  
Md. Reazul Islam ◽  
Rubaiya Ali ◽  
S. M. Matiur Rahman ◽  
...  
Keyword(s):  
Trace Elements ◽  
Vitamin E ◽  
Atomic Absorption ◽  
Fungal Infections ◽  
Seborrheic Dermatitis ◽  
Serum Levels ◽  
Case Control ◽  
Uv Spectrophotometry ◽  
Predictive Tool ◽  
Flame Atomic Absorption

AbstractBackgroundThere are many theories abound; the exact mechanism for the pathophysiology of seborrheic dermatitis (SD) remains unknown. Neuropsychiatric disorders, stress, weakened or irregular immune responses, fungal infections, etc. are thought to be associated with the development of SD. The present study aimed to determine the serum levels of trace elements (TEs), macro-minerals (MMs), antioxidant vitamins, malondialdehyde (MDA), and immunoglobulins in SD patients to explore their role in the disease progression.MethodsThis prospective case-control study recruited 75 SD patients and 76 healthy controls (HCs) matched by age and gender. Serum TEs and MMs were analyzed by the flame atomic absorption spectroscopy and graphite furnace atomic absorption spectrometry. RP-HPLC was used to determine the serum levels of vitamin A and E. Serum MDA levels were measured by UV spectrophotometry as a marker of lipid peroxidation, whereas the turbidimetric method was used to quantify the serum levels of immunoglobulins.ResultsWe found significantly higher concentrations of serum copper, manganese, and iron, calcium, and magnesium in SD patients compared to HCs. Serum levels of vitamin E significantly decreased and serum levels of MDA significantly increased in SD patients. Besides, the lower concentrations of immunoglobulin A, G, and M were observed in SD patients when compared to HCs. The present study also found a positive correlation between serum Zn and Ca levels (r = 0.365, p = 0.009) in SD patients; whereas a negative relation was detected between serum Cu and Ca levels (r = -0.298, p = 0.035).ConclusionsThe present study suggests that increased levels of TEs, MMs, MDA, and decreased levels of immunoglobulins and vitamin E are strongly associated with the pathophysiology of SD. Moreover, these alterations may provide a predictive tool for the assessment and management of SD patients.

scholarly journals Trace Element Assessment in Fingernails of Adult Females

2018 ◽  
Vol 1 (1) ◽  
pp. a8-15
Author(s):  
LAURA DINES NGAU ◽  
BOON SIONG WEE ◽  
NAZARATUL ASHIFA ABD SALIM
Keyword(s):  
Trace Elements ◽  
Trace Element ◽  
Atomic Absorption ◽  
Absorption Spectroscopy ◽  
Atomic Absorption Spectroscopy ◽  
The Body ◽  
Flame Atomic Absorption Spectroscopy ◽  
Elemental Concentrations ◽  
Flame Atomic Absorption ◽  
Adult Females

Trace elements play a significant role in giving nutritional benefits to the body because they act as essential cofactors for all physiological processes. However, there are some trace elements which may bring more harm than good when entering the human body. Due to its ability to incorporate trace elements in an amount that is proportional to an individual’s dietary intake and environmental exposure, human fingernails are suitable biomarkers in assessing the health status of an individual as they reflect on the trace element concentration present in the body. This study has analysed fingernail samples of 23 adult females residing in Kuching and Kota Samarahan, Sarawak, Malaysia for four elements, namely Cd, Cu, Pb and Zn. By using flame atomic absorption spectroscopy (FAAS), the mean elemental concentrations found in fingernail samples of research participants were 171.8 ± 33.8 μg/g for Zn, 27.8 ± 14.8 μg/g for Cu and 2.64 ± 0.94 μg/g for Pb. Cd concentrations were not able to be detected as they were below the detection limits. A standard reference material, NIST 1568b Rice Flour was used to verify the methods used in elemental analysis using FAAS. Independent t-test which was used to compare the means of Zn and Cu between vegetarians and non-vegetarians showed no significant differences for both elements. Moreover, correlation analysis showed negative correlations between Cu/Zn pair and Pb/Zn pair, whereas significant positive correlation was obtained for Cu/Pb pair. The overall data from this study showed good agreements with data obtained from studies in other countries. Therefore, the current data in this study represents the latest background elemental concentrations in fingernails of the residents in Kuching and Kota Samarahan, Sarawak.Keywords: Adult females, fingernails, flame atomic absorption spectroscopy (FAAS), trace elements

Serum Concentration of Depot Neuroleptics in Tardive Dyskinesia

1983 ◽  
Vol 142 (6) ◽  
pp. 579-583 ◽  
Author(s):  
A. F. Fairbairn ◽  
F. J. Rowell ◽  
S. M. Hui ◽  
F. Hassanyeh ◽  
A. J. Robinson ◽  
...  
Keyword(s):  
Plasma Concentration ◽  
Serum Concentration ◽  
Tardive Dyskinesia ◽  
Serum Levels ◽  
Drug Dose ◽  
Chronic Schizophrenic ◽  
Significant Difference ◽  
Depot Neuroleptics ◽  
Schizophrenic Patients

SummaryUsing radioimmunoassay techniques, serum levels of depot neuroleptics, fluphenazine and flupenthixol, were estimated in two groups of chronic schizophrenic patients with, and without, tardive dyskinesia. There were high correlations between drug dose and plasma concentration. There was no significant difference in dose-related serum levels of either drug between the groups.The hypothesis that patients with tardive dyskinesia develop the syndrome because they do not metabolise neuroleptics as efficiently as those without the syndrome was not supported by the data.

scholarly journals Determination of Some Trace Elements in Breast Cancer Serum by Atomic Absorption Spectroscopy

2016 ◽  
Vol 9 (1) ◽  
pp. 1 ◽  
Author(s):  
Safaa Sabri Najim
Keyword(s):  
Breast Cancer ◽  
Trace Elements ◽  
Atomic Absorption ◽  
Cancer Patients ◽  
Absorption Spectroscopy ◽  
Atomic Absorption Spectroscopy ◽  
Serum Levels ◽  
Control Group ◽  
Breast Cancer Patients ◽  
Flame Atomic Absorption

In the breast cancer significant differences occurs in the normal distribution of the trace elements, playing an important role in carcinogenic process. The aim of this study was to investigate the serum levels of some trace elements (Chromium, Cadmium, Manganese, Cobalt, Nickel, Selenium, Zinc, Iron, Copper and Magnesium) by using flame atomic absorption spectroscopy (FAAS). The present study included 150 females, the participates were divided into two main groups, control group which consisted of 75 apparently healthy females, 75patients with breast cancer group .The serum levels of Chromium (tcal2.9631 ,ttab1.960), Cadmium (tcal2.0798 ,ttab1.960), Manganese (tcal18.5676, ttab1.960), Selenium (tcal2.2759,ttab1.960), Iron (tcal2.9296,ttab1.960), Copper (tcal4.0869, ttab1.960),Magnesium (tcal2.6648, ttab1.960), Cobalt (tcal3.8615 , ttab1.960) and Zinc (tcal7.0160, ttab1.960) were statistically significant higher in the breast cancer patients group than the control group. Similarly, Nickel (tcal1.5988,ttab1.960) levels showed significant lower level in breast cancer patients group. On the other hand, the higher levels of trace elements could lead to formation of free radicals or other reactive oxygen species. The evaluation of these trace elements in serum maybe used as helpful tool in diagnosis of the breast cancer.

scholarly journals Effect of Serum Trace Elements, Macro-minerals and Antioxidants in Acne Vulgaris Patients: A Case-Control Study

2017 ◽  
Vol 15 (2) ◽  
pp. 215-220
Author(s):  
Salma Ahmed ◽  
Rubaiya Ali ◽  
Md Reazul Islam ◽  
Md Anamul Hoque ◽  
Abul Hasnat ◽  
...  
Keyword(s):  
Trace Elements ◽  
Vitamin A ◽  
Acne Vulgaris ◽  
Flame Atomic Absorption Spectroscopy ◽  
Flame Atomic Absorption ◽  
Causative Factors ◽  
Exact Etiology ◽  
Chronic Skin ◽  
Serum Trace Elements ◽  
Control Study

Acne vulgaris is a chronic skin disease with multifaceted cause. The exact etiology and pathogenesis of acne are yet to be established completely and various causative factors are considered as pathogenic mechanisms in the development of this disorder. We designed a study to determine the extent of serum trace elements, macrominerals and antioxidants in patients with acne, and thereby, to find the pathophysiological correlations, if any. Serum trace elements and macro-minerals were determined by flame atomic absorption spectroscopy. RP-HPLC was used to quantify antioxidants. Significantly (p<0.05) decreased level of zinc (1.90±0.06 vs. 2.17±0.09 mg/L), calcium (115.64±4.84 vs. 197.05±7.11 mg/L) and vitamin A (0.2±0.06 vs. 0.86±0.26 ?mol/L) was found in patient when compared with the corresponding controls. This investigation suggests a commendable association between the pathogenesis of acne vulgaris with the reduced level of zinc, calcium and vitamin A which could well be used as a diagnostic tool for acne vulgaris.Dhaka Univ. J. Pharm. Sci. 15(2): 215-220, 2016 (December)

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