Molecularly imprinted membrane with innovative structure and high performance for chiral separation of amino acids

2017 ◽  
Vol 67 (8) ◽  
pp. 517-527 ◽  
Author(s):  
Baojiao Gao ◽  
Yanbin Li ◽  
Kunli Cui
Keyword(s):  
Amino Acids ◽  
Chiral Separation ◽  
High Performance ◽  
Molecularly Imprinted ◽  
Molecularly Imprinted Membrane ◽  
Imprinted Membrane

scholarly journals Molecularly imprinted membrane for transport of urea, creatinine, and vitamin B12 as a hemodialysis candidate membrane

2021 ◽  
Vol 19 (1) ◽  
pp. 806-817
Author(s):  
Muhammad Cholid Djunaidi ◽  
Nabilah Anindita Febriola ◽  
Abdul Haris
Keyword(s):  
Polyethylene Glycol ◽  
Vitamin B12 ◽  
Kidney Function ◽  
Cross Linking ◽  
Vitamin B ◽  
Molecularly Imprinted ◽  
Selective Transport ◽  
Molecularly Imprinted Membrane ◽  
Better Than ◽  
Imprinted Membrane

Abstract High levels of urea and creatinine in the blood are a sign of decreased kidney function. To remove these substances from the blood, hemodialysis which utilizes membranes could be used. In this study, a molecularly imprinted membrane (MIM) was synthesized for the selective transport of urea. The synthesis is initiated with the polymerization of eugenol into polyeugenol and then into polyeugenoxy acetate (PA). The PA is then contacted with urea and then used as the functional polymer in the synthesis of MIM with polysulfone as the membrane base, and polyethylene glycol as the cross-linking agent. The result was later analyzed with FTIR and SEM-EDX. The membrane is then used in the transport of urea, creatinine, and vitamin B12 and then compared with the non-imprinted membrane (NIM) performance. By using UV-Vis spectrophotometry, the results showed that the membrane with 10 h heating variation is able to transport more urea and is more selective than NIM; this proves that the urea template on the MIM enables it to recognize urea molecules better than creatinine and vitamin B12. The order of transport from the best results is urea > creatinine > vitamin B12.

Separation of Naproxen Enantiomers Using Hollow Fiber Molecularly Imprinted Membrane Chromatography

2011 ◽  
Vol 40 (3) ◽  
pp. 266-267 ◽  
Author(s):  
Nai Ci Bing ◽  
Zhen Tian ◽  
Hai Ying Jin ◽  
Li Jun Wang ◽  
Lu Ping Zhu ◽  
...  
Keyword(s):  
Hollow Fiber ◽  
Molecularly Imprinted ◽  
Membrane Chromatography ◽  
Molecularly Imprinted Membrane ◽  
Imprinted Membrane

Study on the Weakest Interaction Model for Chiral Resolution Using Molecularly Imprinted Polymer

2011 ◽  
Vol 391-392 ◽  
pp. 111-115 ◽  
Author(s):  
Fei Rong ◽  
Ping Li
Keyword(s):  
Chiral Separation ◽  
Molecularly Imprinted Polymers ◽  
Separation Factor ◽  
High Performance ◽  
Stationary Phases ◽  
Interaction Model ◽  
Template Molecule ◽  
Separation Procedure ◽  
Recognition Mechanism ◽  
Molecularly Imprinted

Molecularly imprinted polymers (MIPs) of L-phenylalanine ethyl ester were synthesized in this study. Then, the prepared MIPs were packed in a stainless column and evaluated as the chiral stationary phases of high performance liquid chromatography (HPLC). The MIPs exhibited a considerable capability of chiral separation between template molecule and its enantiomer with the separation factor of 1.69. Furthermore, the weakest interaction model was introduced to study the chiral recognition mechanism of MIPs. The results suggested that the weakest interaction between the template molecule and the imprinted cavity played crucial role in chiral separation, and the molecular tension should be taken into consideration during the separation procedure. The separation factor of 2.07 was calculated by the theoretical model, which was very close to the value obtained from chromatographic experiment.

Sign in / Sign up

Export Citation Format

Share Document