Lipase-catalyzed synthesis of pH-responsive poly(β-thioether ester)-b-poly(ethylene glycol)-b-poly(β-thioether ester) amphiphilic triblock copolymers for drug delivery

2018 ◽  
Vol 68 (10) ◽  
pp. 564-574 ◽  
Author(s):  
Wan-Xia Wu ◽  
Xian-Ling Yang ◽  
Xiong Wang ◽  
Yin Zhang ◽  
Han-Mei Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Triblock Copolymers ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Synthesis and self-assembly behaviour of poly(Nα-Boc-l-tryptophan)-block-poly(ethylene glycol)-block-poly(Nα-Boc-l-tryptophan)

RSC Advances ◽  
2016 ◽  
Vol 6 (29) ◽  
pp. 24142-24153
Author(s):  
Andreea S. Voda ◽  
Kevin Magniez ◽  
Nisa V. Salim ◽  
Cynthia Wong ◽  
Qipeng Guo
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Potential Drug ◽  
Poly Ethylene Glycol ◽  
Drug Delivery Applications ◽  
Poly Ethylene ◽  
First Time

We report for the first time the use of Nα-Boc-l-tryptophan for the synthesis of amphiphilic BAB triblock copolymers for potential drug delivery applications.

A Tunable pH-Responsive Nanomaterials for Cancer Delivery

2013 ◽  
Vol 750-752 ◽  
pp. 1476-1479 ◽  
Author(s):  
Bin Liu ◽  
Guan Hui Gao ◽  
Peng Liu ◽  
Hu Qiang Yi ◽  
Wei Wei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Potential Application ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Positive Potential ◽  
Ph Values ◽  
Drugs In Blood ◽  
Poly Ethylene

In this paper, we successfully designed a pH-responsive micelles based on hybrid polypeptide copolymers of poly (L-lysine-4-Azepan-1-yl-butyric)-b-poly (ethylene glycol)-b-poly (L-lysine-Diisopropylamide)-b-poly (L-leucine) (PLL(A)-PEG-PLL(B)-PLLeu) for efficient drug delivery. This pH-responsive nanoparticles were able to response to different pH values (pH=6.8 and 5.5). In vitro, these nanoparticles exhibited a stable and evenly distributed approximately 51 nm, a slightly positive potential about 10.3 mv at pH 7.4, which were crucial for the circulation of drugs in blood. While size and potential were about 130 nm and 34.7 mv at pH 6.8, which were good for drugs in membrane. Furthermore, the loading capability of DOX was up to 11.3%, and the pH-responsive release efficiency reached to 68.3% at pH 5.5. The results indicated that these micelles had huge potential application in cancer delivery.

scholarly journals pH-Responsive Poly(Ethylene Glycol)-block-Polylactide Micelles for Tumor-Targeted Drug Delivery

2017 ◽  
Vol 18 (9) ◽  
pp. 2711-2722 ◽  
Author(s):  
Lin Xiao ◽  
Lixia Huang ◽  
Firmin Moingeon ◽  
Mario Gauthier ◽  
Guang Yang
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Targeted Drug ◽  
Poly Ethylene

pH-sensitive polymeric micelles assembled by stereocomplexation between PLLA-b-PLys and PDLA-b-mPEG for drug delivery

2019 ◽  
Vol 7 (2) ◽  
pp. 334-345 ◽  
Author(s):  
Zhaoyuan Guo ◽  
Ke Zhao ◽  
Rong Liu ◽  
Xiaolan Guo ◽  
Bin He ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Ethylene Glycol ◽  
Polymeric Micelles ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

pH-responsive stereocomplexed micelles based on poly(l-lactic acid)-b-polylysine/poly(d-lactic acid)-b-methoxy poly(ethylene glycol) (PLLA-b-PLys/PDLA-b-mPEG) were fabricated by stereocomplexation between enantiomeric PLA segments.

A pH-responsive polymer based on dynamic imine bonds as a drug delivery material with pseudo target release behavior

2018 ◽  
Vol 9 (7) ◽  
pp. 878-884 ◽  
Author(s):  
Yangchun Tao ◽  
Siwei Liu ◽  
Yi Zhang ◽  
Zhenguo Chi ◽  
Jiarui Xu
Keyword(s):  
Drug Delivery ◽  
Schiff Base ◽  
Ethylene Glycol ◽  
Release Behavior ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Triggered Release ◽  
Responsive Polymer ◽  
Poly Ethylene

In this study, pentaerythritol tetra(3-mercaptopropionate)-allylurea-poly(ethylene glycol) (PETMP-AU-PEG), produced by the Schiff-base reaction between terminal-aldehyded PEG and PETMP-AU, was used to prepare doxorubicin (DOX)-loaded polymers for triggered release.

Sign in / Sign up

Export Citation Format

Share Document