Thermo- and pH-responsive copolymer poly(t-butyl acrylate)-b-poly{[2-(dimethylamino) ethyl methacrylate]-co-[poly(ethylene glycol) methyl ether methacrylate]}: Preparation, characterization, and their applications as organic dye adsorbents and drug delivery systems

In this paper, we successfully designed a pH-responsive micelles based on hybrid polypeptide copolymers of poly (L-lysine-4-Azepan-1-yl-butyric)-b-poly (ethylene glycol)-b-poly (L-lysine-Diisopropylamide)-b-poly (L-leucine) (PLL(A)-PEG-PLL(B)-PLLeu) for efficient drug delivery. This pH-responsive nanoparticles were able to response to different pH values (pH=6.8 and 5.5). In vitro, these nanoparticles exhibited a stable and evenly distributed approximately 51 nm, a slightly positive potential about 10.3 mv at pH 7.4, which were crucial for the circulation of drugs in blood. While size and potential were about 130 nm and 34.7 mv at pH 6.8, which were good for drugs in membrane. Furthermore, the loading capability of DOX was up to 11.3%, and the pH-responsive release efficiency reached to 68.3% at pH 5.5. The results indicated that these micelles had huge potential application in cancer delivery.

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Controlling the morphology of glyco-nanoparticles in water using block copolymer mixtures: the effect on cellular uptake

Polymer Chemistry ◽

10.1039/c5py01360g ◽

2015 ◽

Vol 6 (45) ◽

pp. 7812-7820 ◽

Cited By ~ 14

Author(s):

Aydan Dag ◽

Hongxu Lu ◽

Martina Stenzel

Keyword(s):

Block Copolymer ◽

Ethylene Glycol ◽

Cellular Uptake ◽

Methyl Ether ◽

Butyl Acrylate ◽

Diblock Copolymers ◽

Ethyl Acrylate ◽

Poly Ethylene Glycol ◽

Poly Ethylene ◽

Glycol Methyl Ether

Poly[(2-(α-d-mannosyloxy)ethyl acrylate)-block-(n-butyl acrylate)], P(ManA-b-BA), and poly[poly(ethylene glycol) methyl ether acrylate]-block-(n-butyl acrylate)], P(OEGMEA-b-BA) diblock copolymers were mixed at various ratios to generate self-assembled structures of different morphologies.

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Anticancer drug delivery systems: multi-loaded N4-acyl poly(ethylene glycol) prodrugs of ara-C.II. Efficacy in ascites and solid tumors

Journal of Controlled Release ◽

10.1016/s0168-3659(01)00470-9 ◽

2002 ◽

Vol 79 (1-3) ◽

pp. 55-70 ◽

Cited By ~ 57

Author(s):

Y CHOE ◽

C CONOVER ◽

D WU ◽

M ROYZEN ◽

Y GERVACIO ◽

...

Keyword(s):

Drug Delivery ◽

Ethylene Glycol ◽

Solid Tumors ◽

Anticancer Drug ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Poly Ethylene Glycol ◽

Anticancer Drug Delivery ◽

Poly Ethylene

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pH-Responsive Poly(Ethylene Glycol)-block-Polylactide Micelles for Tumor-Targeted Drug Delivery

Biomacromolecules ◽

10.1021/acs.biomac.7b00509 ◽

2017 ◽

Vol 18 (9) ◽

pp. 2711-2722 ◽

Cited By ~ 23

Author(s):

Lin Xiao ◽

Lixia Huang ◽

Firmin Moingeon ◽

Mario Gauthier ◽

Guang Yang

Keyword(s):

Drug Delivery ◽

Ethylene Glycol ◽

Targeted Drug Delivery ◽

Ph Responsive ◽

Poly Ethylene Glycol ◽

Targeted Drug ◽

Poly Ethylene

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The Swelling and Transition Behavior of Thermo-Responsive Poly(2-(2-Methoxyethoxy) Ethoxyethyl Methacrylate-co-Poly(Ethylene Glycol) Methyl Ether Methacrylate) Thin Films

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.873.59 ◽

2021 ◽

Vol 873 ◽

pp. 59-64

Author(s):

Yang Yi Chen ◽

Wen Jing Wen ◽

Zhi Qin Su ◽

Qi Huan ◽

Chu Yang Zhang

Keyword(s):

Thin Films ◽

Ethylene Glycol ◽

Methyl Ether ◽

Random Copolymer ◽

Molar Ratio ◽

Poly Ethylene Glycol ◽

H Nmr ◽

Poly Ethylene ◽

Copolymer Poly ◽

Glycol Methyl Ether

Thermo-responsive random copolymer poly (2-(2-methoxyethoxy) ethoxyethyl methacrylate-co-poly (ethylene glycol) methyl ether methacrylate), abbreviated as P(MEO2MA-co-OEGMA300) was synthesized by 2-(2-methoxyethoxy) ethoxyethyl methacrylate (MEO2MA) and poly (ethylene glycol) methyl ether methacrylate (OEGMA300) with a molar ratio of 1:1 via atom transfer radical polymerization (ATRP). The structure of P(MEO2MA-co-OEGMA300) was confirmed by 1H NMR and GPC. The transition behaviors of P(MEO2MA-co-OEGMA300) in aqueous solution were investigated by UV-Vis and DLS. While the transition behaviors of P(MEO2MA-co-OEGMA300) thin films were probed by white light interferometry. Compared to the P(MEO2MA-co-OEGMA300) in solution, it shows a much broader transition region, which is a promising candidate for the slow release of drug in the field of medicine.

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