A pH-responsive polymer based on dynamic imine bonds as a drug delivery material with pseudo target release behavior

2018 ◽  
Vol 9 (7) ◽  
pp. 878-884 ◽  
Author(s):  
Yangchun Tao ◽  
Siwei Liu ◽  
Yi Zhang ◽  
Zhenguo Chi ◽  
Jiarui Xu
Keyword(s):  
Drug Delivery ◽  
Schiff Base ◽  
Ethylene Glycol ◽  
Release Behavior ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Triggered Release ◽  
Responsive Polymer ◽  
Poly Ethylene

In this study, pentaerythritol tetra(3-mercaptopropionate)-allylurea-poly(ethylene glycol) (PETMP-AU-PEG), produced by the Schiff-base reaction between terminal-aldehyded PEG and PETMP-AU, was used to prepare doxorubicin (DOX)-loaded polymers for triggered release.

A Tunable pH-Responsive Nanomaterials for Cancer Delivery

2013 ◽  
Vol 750-752 ◽  
pp. 1476-1479 ◽  
Author(s):  
Bin Liu ◽  
Guan Hui Gao ◽  
Peng Liu ◽  
Hu Qiang Yi ◽  
Wei Wei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Potential Application ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Positive Potential ◽  
Ph Values ◽  
Drugs In Blood ◽  
Poly Ethylene

In this paper, we successfully designed a pH-responsive micelles based on hybrid polypeptide copolymers of poly (L-lysine-4-Azepan-1-yl-butyric)-b-poly (ethylene glycol)-b-poly (L-lysine-Diisopropylamide)-b-poly (L-leucine) (PLL(A)-PEG-PLL(B)-PLLeu) for efficient drug delivery. This pH-responsive nanoparticles were able to response to different pH values (pH=6.8 and 5.5). In vitro, these nanoparticles exhibited a stable and evenly distributed approximately 51 nm, a slightly positive potential about 10.3 mv at pH 7.4, which were crucial for the circulation of drugs in blood. While size and potential were about 130 nm and 34.7 mv at pH 6.8, which were good for drugs in membrane. Furthermore, the loading capability of DOX was up to 11.3%, and the pH-responsive release efficiency reached to 68.3% at pH 5.5. The results indicated that these micelles had huge potential application in cancer delivery.

scholarly journals pH-Responsive Poly(Ethylene Glycol)-block-Polylactide Micelles for Tumor-Targeted Drug Delivery

2017 ◽  
Vol 18 (9) ◽  
pp. 2711-2722 ◽  
Author(s):  
Lin Xiao ◽  
Lixia Huang ◽  
Firmin Moingeon ◽  
Mario Gauthier ◽  
Guang Yang
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Targeted Drug ◽  
Poly Ethylene

scholarly journals Gold nanorods coated with a thermo-responsive poly(ethylene glycol)-b-poly(N-vinylcaprolactam) corona as drug delivery systems for remotely near infrared-triggered release

2014 ◽  
Vol 5 (3) ◽  
pp. 799-813 ◽  
Author(s):  
Ji Liu ◽  
Christophe Detrembleur ◽  
Marie-Claire De Pauw-Gillet ◽  
Stéphane Mornet ◽  
Etienne Duguet ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Gold Nanorods ◽  
Drug Delivery Systems ◽  
Near Infrared ◽  
Delivery Systems ◽  
Poly Ethylene Glycol ◽  
Triggered Release ◽  
Poly Ethylene

pH-sensitive polymeric micelles assembled by stereocomplexation between PLLA-b-PLys and PDLA-b-mPEG for drug delivery

2019 ◽  
Vol 7 (2) ◽  
pp. 334-345 ◽  
Author(s):  
Zhaoyuan Guo ◽  
Ke Zhao ◽  
Rong Liu ◽  
Xiaolan Guo ◽  
Bin He ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Ethylene Glycol ◽  
Polymeric Micelles ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

pH-responsive stereocomplexed micelles based on poly(l-lactic acid)-b-polylysine/poly(d-lactic acid)-b-methoxy poly(ethylene glycol) (PLLA-b-PLys/PDLA-b-mPEG) were fabricated by stereocomplexation between enantiomeric PLA segments.

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