Fabrication of a molecular imprinted composite and its application in the measurement of ceftriaxone in an electrochemical sensor

Background:: new and selective electrochemical sensor was developed for the determination of levocetirizine dihydrochloride, which is an antihistaminic drug. Method:: The investigation was performed by using cyclic, differential pulse and square wave voltammetric methods on the β-cyclodextrin modified glassy carbon electrode. It is thereby planned to obtain information about levocetirizine determination and its mechanism. Result:: The efficiency of experimental parameters including pH, scan rate, and accumulation potential and time on the anodic response of levocetirizine dihydrochloride was studied. By employing the developed method and under optimized conditions, the current showed linear dependence with a concentration in the range between 2 × 10-8 M and 6 × 10-6 M in pH 2.0 Britton Robinson (BR) buffer. Conclusion:: The achieved limits of detection and quantification were found as 3.73 × 10-10 M and 1.24 × 10-9 M, respectively. In addition, the possibility of applying the developed sensor for real sample analysis was investigated, so β-cyclodextrin modified glassy carbon electrode was used to determine levocetirizine dihydrochloride in Xyzal® tablet dosage form. Finally, this sensor was successfully applied to the real sample as a selective, simple, reproducible, repeatable electrochemical sensor.

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Facile and Fast Detection of Genistein in Derris scandens by Square Wave Voltammetry using a Cobalt(II) Phthalocyanine-Modified Screen-Printed Electrochemical Sensor

Current Analytical Chemistry ◽

10.2174/1573411014666180521091053 ◽

2020 ◽

Vol 16 (3) ◽

pp. 341-348

Author(s):

Surinya Traipop ◽

Suchada Chuanuwatanakul ◽

Orawon Chailapakul ◽

Eakkasit Punrat

Keyword(s):

Electrochemical Sensor ◽

Square Wave Voltammetry ◽

Silver Chloride ◽

Reference Electrode ◽

High Sensitivity ◽

Plastic Substrate ◽

Fast Analysis ◽

Square Wave ◽

Wave Voltammetry ◽

Screen Printed

Background: Recently, Derris scandens, a Thai herbal medicine with anti-inflammatory activity, is widely used as beverage and supplementary food. When the traditional medicine is a choice for health therapy, the simple and reliable equipment is required to control the suitable consuming amount of the active component. Objective: To develop the electrochemical sensor for genistein determination in Derris scandens with high sensitivity and rapid operation. Methods: An in-house screen-printed electrochemical sensor consisting of a three-electrode system was developed for genistein determination. A silver/silver chloride (Ag/AgCl) reference electrode, a carbon counter electrode and a carbon working electrode were prepared on a 0.3-mm-thick plastic substrate by the screen-printing technique using conductive ink. The dimensions of each sensor were 2.5×1.0 cm. Only 50 µL of sample solution was required on this device for the determination of genistein concentration by rapid response square wave voltammetry. Results: The oxidation peak of genistein appeared with good response in acidic media at a peak potential of 0.6 V. Moreover, the signal was enhanced by modifying the conductive carbon ink with cobalt( II) phthalocyanine. Under the optimized conditions, the linear range was found to be 2.5-150 µM and the detection limit was 1.5 µM. Moreover, the small volume extraction was successfully developed without any further pre-concentration. This proposed method was applied to determine genistein in Derris scandens with satisfying results. Conclusion: The proposed method is promising as an alternative method for genistein determination with facile and fast analysis.

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A Simple and Sensitive Hydrazine Electrochemical Sensor Based on Platinum Nanoclusters

Current Analytical Chemistry ◽

10.2174/1573411011666150407231732 ◽

2015 ◽

Vol 11 (4) ◽

pp. 237-243 ◽

Cited By ~ 6

Author(s):

Zhou Yaoyu ◽

Tang Lin ◽

Xie Xia ◽

Zeng Guangming ◽

Gong Jilai ◽

...

Keyword(s):

Electrochemical Sensor ◽

Platinum Nanoclusters

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A Sensitive and Selective Electrochemical Sensor for Sulfadimethoxine Based on Electropolymerized Molecularly Imprinted Poly (o-aminophenol) Film

Current Analytical Chemistry ◽

10.2174/1573411015666190103144415 ◽

2020 ◽

Vol 16 (4) ◽

pp. 413-420 ◽

Cited By ~ 3

Author(s):

Youyuan Peng ◽

Qiaolan Ji

Keyword(s):

Electrochemical Sensor ◽

Polymer Film ◽

Water Samples ◽

Differential Pulse ◽

Imprinted Polymer ◽

Molecularly Imprinted ◽

Long Term Stability ◽

Multi Walled Carbon Nanotubes ◽

Aquaculture Water ◽

Walled Carbon Nanotubes

Background: As a broad-spectrum antibiotic of the sulfonamide family, Sulfadimethoxine (SDM) has been widely utilized for therapeutic and growth-promoting purposes in animals. However, the use of SDM can cause residual problems. Even a low concentration of SDM in the aquatic system can exert toxic effects on target organisms and green algae. Therefore, the quantitation of SDM residues has become an important task. Methods: The present work describes the development of a sensitive and selective electrochemical sensor for sulfadimethoxine based on molecularly imprinted poly(o-aminophenol) film. The molecular imprinted polymer film was fabricated by electropolymerizing o-aminophenol in the presence of SDM after depositing carboxylfunctionalized multi-walled carbon nanotubes onto a glassy carbon electrode surface. SDM can be quickly removed by electrochemical methods. The imprinted polymer film was characterized by cyclic voltammetry, differential pulse voltammetry and scanning electron microscopy. Results: Under the selected optimal conditions, the molecularly imprinted sensor shows a linear range from 1.0 × 10-7 to 2.0 × 10-5 mol L-1 for SDM, with a detection limit of 4.0 × 10-8 mol L-1. The sensor was applied to the determination of SDM in aquaculture water samples successfully, with the recoveries ranging from 95% to 106%. Conclusion: The proposed sensor exhibited a high degree of selectivity for SDM in comparison to other structurally similar molecules, along with long-term stability, good reproducibility and excellent regeneration capacity. The sensor may offer a feasible strategy for the analysis of SDM in aquaculture water samples.

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Graphene Modified Molecular Imprinting Electrochemical Sensor for Determining the Content of Dopamine

Current Analytical Chemistry ◽

10.2174/1573411014666180730112304 ◽

2019 ◽

Vol 15 (6) ◽

pp. 628-634

Author(s):

Rong Liu ◽

Jie Li ◽

Tongsheng Zhong ◽

Liping Long

Keyword(s):

Electrochemical Sensor ◽

Molecular Imprinting ◽

Neurological Disorders ◽

Room Temperature ◽

Low Cost ◽

Differential Pulse ◽

Current Response ◽

Specific Selectivity ◽

Pulse Voltammetry

Background: The unnatural levels of dopamine (DA) result in serious neurological disorders such as Parkinson’s disease. Electrochemical methods which have the obvious advantages of simple operation and low-cost instrumentation were widely used for determination of DA. In order to improve the measurement performance of the electrochemical sensor, molecular imprinting technique and graphene have always been employed to increase the selectivity and sensitivity. Methods: An electrochemical sensor which has specific selectivity to (DA) was proposed based on the combination of a molecular imprinting polymer (MIP) with a graphene (GR) modified gold electrode. The performance and effect of MIP film were investigated by differential pulse voltammetry (DPV) and cyclic voltammetry (CV) in the solution of 5.0 ×10-3 mol/L K3[Fe(CN)6] and K4[Fe(CN)6] with 0.2 mol/L KCl at room temperature. Results: This fabricated sensor has well repeatability and stability, and was used to determine the dopamine of urine. Under the optimized experiment conditions, the current response of the imprinted sensor was linear to the concentration of dopamine in the range of 1.0×10-7 ~ 1.0×10-5 mol/L, the linear equation was I (µA) = 7.9824+2.7210lgc (mol/L) with the detection limit of 3.3×10-8 mol/L. Conclusion: In this work, a highly efficient sensor for determination of DA was prepared with good sensitivity by GR and great selectivity of high special recognization ability by molecular imprinting membrane. This proposed sensor was used to determine the dopamine in human urine successfully.

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