Simultaneous confidence intervals of estimable functions based on quasi-likelihood in generalized linear models for over-dispersed data

2020 ◽  
Vol 91 (1) ◽  
pp. 108-127
Author(s):  
Bo Li
Keyword(s):  
Confidence Intervals ◽  
Generalized Linear Models ◽  
Linear Models ◽  
Simultaneous Confidence Intervals ◽  
Estimable Functions

Covariance Generalized Linear Models: An Approach for Quantifying Uncertainty in Tree Stem Taper Modeling

2021 ◽  
Author(s):  
Luan Demarco Fiorentin ◽  
Wagner Hugo Bonat ◽  
Allan Libanio Pelissari ◽  
Sebastião do Amaral Machado ◽  
Saulo Jorge Téo
Keyword(s):  
Covariance Matrix ◽  
Confidence Intervals ◽  
Generalized Linear Models ◽  
Linear Models ◽  
Mixed Effect Model ◽  
Mixed Effect ◽  
Stem Taper ◽  
Effect Model ◽  
The Mean ◽  
Tree Stem

Abstract A natural dependence among diameters measured within-tree is expected in taper data due to the hierarchical structure. The aim of this paper was to introduce the covariance generalized linear model (CGLM) framework in the context of forest biometrics for Pinus taeda stem form modeling. The CGLMs are based on marginal specification, which requires a definition of the mean and covariance components. The tree stem mean profiles were modeled by a nonlinear segmented model. The covariance matrix was built considering four strategies of linear combinations of known matrices, which expressed the variance or correlations among observations. The first strategy modeled only the variance of the diameters over the stem as a function of covariates, the second modeled correlation among observations, the third was defined based on a random walk model, the fourth was based on a structure similar to a mixed-effect model with a marginal specification, and the fourth was a traditional mixed-effect model. Mean squared error and bias showed that the approaches were similar for describing the mean profile for fitting and validation dataset. However, uncertainties expressed by confidence intervals of the relative diameters were significant and related to the matrix covariance structures of the CGLMs. Study Implications: We proposed stem taper modeling based on a new class of statistical models. Covariance generalized linear models allow quantification of the stem dynamic by using a nonlinear model. Uncertainty estimates are performed on a covariance matrix given by a linear combination of known matrices. The matrices enable modeling of the nonconstant variance as well as the several correlation patterns, resulting in a framework more flexible and robust than traditional approaches usually applied for stem taper modeling. For practical purposes, uncertainty modeling can improve forest management planning, because the production limits by timber assortments are more reliable due to the confidence intervals derived from an appropriate uncertainty analysis.

Effect of Different Dentifrices, Bleaching with 35% Hydrogen Peroxide, and Red Wine on Surface Color and Roughness of Bovine Enamel

2020 ◽  
Vol 02 ◽  
Author(s):  
RM Garcia ◽  
WF Vieira-Junior ◽  
JD Theobaldo ◽  
NIP Pini ◽  
GM Ambrosano ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Generalized Linear Models ◽  
Repeated Measures ◽  
Red Wine ◽  
Linear Models ◽  
Artificial Saliva ◽  
Surface Color ◽  
Dental Bleaching ◽  
Surface Alteration ◽  
Bovine Enamel

Objective: To evaluate color and roughness of bovine enamel exposed to dentifrices, dental bleaching with 35% hydrogen peroxide (HP), and erosion/staining by red wine. Methods: Bovine enamel blocks were exposed to: artificial saliva (control), Oral-B Pro-Health (stannous fluoride with sodium fluoride, SF), Sensodyne Repair & Protect (bioactive glass, BG), Colgate Pro-Relief (arginine and calcium carbonate, AR), or Chitodent (chitosan, CHI). After toothpaste exposure, half (n=12) of the samples were bleached (35% HP), and the other half were not (n=12). The color (CIE L*a* b*, ΔE), surface roughness (Ra), and scanning electron microscopy were evaluated. Color and roughness were assessed at baseline, post-dentifrice and/or -dental bleaching, and after red wine. The data were subjected to analysis of variance (ANOVA) (ΔE) for repeated measures (Ra), followed by Tukey ́s test. The L*, a*, and b* values were analyzed by generalized linear models (a=0.05). Results: The HP promoted an increase in Ra values; however, the SF, BG, and AR did not enable this alteration. After red wine, all groups apart from SF (unbleached) showed increases in Ra values; SF and AR promoted decreases in L* values; AR demonstrated higher ΔE values, differing from the control; and CHI decreased the L* variation in the unbleached group. Conclusion: Dentifrices did not interfere with bleaching efficacy of 35% HP. However, dentifrices acted as a preventive agent against surface alteration from dental bleaching (BG, SF, and AR) or red wine (SF). Dentifrices can decrease (CHI) or increase (AR and SF) staining by red wine.

Economic burden of readmission due to postoperative cerebrospinal fluid leak in Chinese patients

2020 ◽  
Vol 9 (16) ◽  
pp. 1105-1115
Author(s):  
Shuqing Wu ◽  
Xin Cui ◽  
Shaoyu Zhang ◽  
Wenqi Tian ◽  
Jiazhen Liu ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Generalized Linear Models ◽  
Economic Burden ◽  
Linear Models ◽  
Chinese Patients ◽  
Cerebrospinal Fluid Leakage ◽  
Index Hospitalization ◽  
Real World Data ◽  
Factors Associated ◽  
Hospitalization Cost

Aim: This real-world data study investigated the economic burden and associated factors of readmissions for cerebrospinal fluid leakage (CSFL) post-cranial, transsphenoidal, or spinal index surgeries. Methods: Costs of CSFL readmissions and index hospitalizations during 2014–2018 were collected. Readmission cost was measured as absolute cost and as percentage of index hospitalization cost. Factors associated with readmission cost were explored using generalized linear models. Results: Readmission cost averaged US$2407–6106, 35–94% of index hospitalization cost. Pharmacy costs were the leading contributor. Generalized linear models showed transsphenoidal index surgery and surgical treatment for CSFL were associated with higher readmission costs. Conclusion: CSFL readmissions are a significant economic burden in China. Factors associated with higher readmission cost should be monitored.

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