SEX HORMONE STATUS IN MALE RATS AFTER EXPOSURE TO 50 HZ, 5 MTESLA MAGNETIC FIELD

The controls of food intake differ in male and female rats. Daily food intake is typically greater in male rats, relative to female rats, and a decrease in food intake, coincident with the estrous stage of the ovarian reproductive cycle, is well documented in female rats. This estrous-related decrease in food intake has been attributed to a transient increase in the female rat's sensitivity to satiety signals generated during feeding bouts. Here, we investigated whether sex or stage of the estrous cycle modulate the satiety signal generated by fenfluramine, a potent serotonin (5-HT) releasing agent. To examine this hypothesis, food intake was monitored in male, diestrous female, and estrous female rats after intraperitoneal injections of 0, 0.25, and 1.0 mg/kg d-fenfluramine. The lower dose of fenfluramine decreased food intake only in diestrous and estrous females, suggesting that the minimally effective anorectic dose of fenfluramine is lower in female rats, relative to male rats. Although the larger dose of fenfluramine decreased food intake in both sexes, the duration of anorexia was greater in diestrous and estrous female rats, relative to male rats. Moreover, the magnitude of the anorectic effect of the larger dose of fenfluramine was greatest in estrous rats, intermediate in diestrous rats, and least in male rats. Thus our findings indicate that the anorectic effect of fenfluramine is modulated by gonadal hormone status.

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Protective effects of estrogen on gender-specific development of diet-induced hypertension

Journal of Applied Physiology ◽

10.1152/jappl.2001.91.5.2005 ◽

2001 ◽

Vol 91 (5) ◽

pp. 2005-2009 ◽

Cited By ~ 21

Author(s):

Christian K. Roberts ◽

Nosratola D. Vaziri ◽

R. James Barnard

Keyword(s):

Body Weight ◽

Female Rats ◽

Male Rats ◽

Gonadal Hormone ◽

Normal Female ◽

Humoral Factors ◽

Diet Modification ◽

Ovx Rats ◽

Hormone Status ◽

Induced Hypertension

Dietary and humoral factors are thought to be involved in the development of hypertension. This study investigated the interaction between diet and gonadal hormone status in the development and reversibility of hypertension. Normal male and female and ovariectomized (OVX) female Fischer rats were placed on either a high-fat (primarily saturated), refined carbohydrate (sucrose) (HFS) or a low-fat, complex carbohydrate (LFCC) diet at 2 mo of age, and body weight and systolic blood pressure (BP) were measured. Male and OVX female rats were initially on the diets for 7 mo, whereas normal female rats were on the diets for 2 yr. After this initial phase, a group of rats from each of the normal HFS groups were converted to the LFCC diet for a period of 1 mo (males) and 2 mo (females). The OVX females were subcutaneously implanted with a 0.5-mg estradiol (E2) pellet for 1 mo. A significant rise in arterial BP occurred within 12 mo in female and only 2 mo in male rats on the HFS diet, exceeding 140 mmHg after 24 and 7 mo, respectively. Conversion from the HFS to the LFCC diet led to a normalization of BP in both female and male rats. HFS diet-induced hypertension was accelerated by OVX in female rats, approaching the pattern seen in male rats. The effect of OVX was completely reversed by E2replacement. BP did not significantly change in any of the LFCC groups at any time point, and E2 replacement had no effect on BP in the OVX LFCC group. All HFS groups had significantly greater body weight, with differences occurring sooner in the male and OVX rats compared with the female rats. Diet modification resulted in a partial but significant reduction of body weight, but E2replacement did not. These results demonstrate that long-term consumption of HFS diet induces hypertension in both genders and is reversible by diet modification. Hypertension is significantly delayed in females with functional ovaries. This protection is lost by OVX and restored by estrogen replacement. Thus hormone status contributes to the delayed onset of diet-induced hypertension in females compared with males.

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Sex hormone status in premenopausal women with frontal fibrosing alopecia: a multicentre review of 43 patients

Clinical and Experimental Dermatology ◽

10.1111/ced.13221 ◽

2017 ◽

Vol 42 (8) ◽

pp. 921-923 ◽

Cited By ~ 8

Author(s):

C. Bernárdez ◽

A. M. Molina-Ruiz ◽

S. Vañó-Galvan ◽

M. Urech ◽

D. Saceda-Corralo ◽

...

Keyword(s):

Premenopausal Women ◽

Sex Hormone ◽

Hormone Status

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The effects of date palm gemmule on sperm quality and sex hormone levels on partial sterile male rats as experimental model

Toxicology Letters ◽

10.1016/j.toxlet.2006.06.164 ◽

2006 ◽

Vol 164 ◽

pp. S79 ◽

Cited By ~ 2

Author(s):

Sogra Bahmanpour ◽

Fereidon Kavoosi ◽

Mohammad Reza Panjehshahin ◽

Tahera Talaei Khozani

Keyword(s):

Experimental Model ◽

Date Palm ◽

Sperm Quality ◽

Sex Hormone ◽

Male Rats ◽

Sterile Male ◽

Hormone Levels

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A suspicious reason for Raynaud’s phenomenon: Intrauterine device

Vascular ◽

10.1177/1708538114558330 ◽

2014 ◽

Vol 23 (3) ◽

pp. 327-328

Author(s):

Adem İ Diken ◽

Adnan Yalçınkaya ◽

Eray Aksoy ◽

Seyhan Yılmaz ◽

Kerim Çağlı

Keyword(s):

Medical Therapy ◽

Raynaud’S Phenomenon ◽

Intrauterine Device ◽

Raynaud's Phenomenon ◽

Sex Hormone ◽

Intrauterine Devices ◽

Postmenopausal Patient ◽

Hormone Status ◽

Primary Raynaud’S Phenomenon ◽

Copper Intrauterine Device

Primary Raynaud’s phenomenon may be insistent in patients under medical therapy, and intrauterine devices may be an unnoticed reason in these patients. Fluctuations in female sex hormone status were reported to be associated with the emergence of primary Raynaud’s phenomenon symptoms. The use of intrauterine devices was not reported to be associated with Raynaud’s phenomenon previously. Intrauterine device may stimulate vascular hyperactivity regarding hormonal or unknown mechanisms that result in Raynaud’s phenomenon. We present a postmenopausal patient who complained of primary Raynaud’s phenomenon symptoms and had recovery after the removal of her copper intrauterine device.

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Effects of static magnetic field exposure on hematological and biochemical parameters in rats

Brazilian Archives of Biology and Technology ◽

10.1590/s1516-89132006000700005 ◽

2006 ◽

Vol 49 (6) ◽

pp. 889-895 ◽

Cited By ~ 12

Author(s):

Salem Amara ◽

Hafedh Abdelmelek ◽

Mohamed Ben Salem ◽

Rached Abidi ◽

Mohsen Sakly

Keyword(s):

Magnetic Field ◽

Static Magnetic Field ◽

Growth Rates ◽

Glucose Concentration ◽

Blood Cells ◽

White Blood Cells ◽

Male Rats ◽

Field Exposure ◽

Protein Levels ◽

Hematological And Biochemical Parameters

The present work was undertaken in order to investigate the effects of static magnetic field (SMF) on growth rates, hematopoiesis, plasmatic proteins levels, glucose concentration, lactate dehydrogenase (LDH) and transaminases activities in male rats. Sub-acute exposure of rats during 5 consecutive days to SMF (1h/day at 128mT) induced an increase of plasma LDH activity (+38%, p<0.05), and glucose concentration (+31%, p<0.05), whereas haematological parameters, protein levels, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities remained unchanged. SMF exposure of rats during 30 consecutive days (1hour/day at 128mT) decreased significantly growth rates by the second week and increased significantly the plasmatic total protein levels (+62%, p<0.05), hemoglobin (+10%, p<0.05), red blood cells (+7%, p<0.05), white blood cells (+17%, p<0.05), and platelet number (+10%, p<0.05). Sub-chronic exposure to SMF increased also LDH (+43%, p<0.05), AST (+ 41%, p<0.05) and ALT activities (+95%, p<0.05). In contrast, the glucose concentration was unaffected. These changes suggested that exposure to SMF had a possible effect on the proliferation of blood cells and enzymes release within blood indicating tissue alterations.

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