Sex hormone status in premenopausal women with frontal fibrosing alopecia: a multicentre review of 43 patients

2017 ◽  
Vol 42 (8) ◽  
pp. 921-923 ◽  
Author(s):  
C. Bernárdez ◽  
A. M. Molina-Ruiz ◽  
S. Vañó-Galvan ◽  
M. Urech ◽  
D. Saceda-Corralo ◽  
...  
1995 ◽  
Vol 133 (2) ◽  
pp. 200-206 ◽  
Author(s):  
Steen B Pedersen ◽  
Jens D Børglum ◽  
Kim Brixen ◽  
Bjørn Richelsen

Pedersen SB, Borglum JD, Brixen K, Richelsen B. Relationship between sex hormones, body composition and metabolic risk parameters in premenopausal women. Eur J Endocrinol 1995;133: 200–6. ISSN 0804–4643 The metabolic complications associated with obesity are dependent upon the degree of obesity and the distribution of adipose tissue. In order to evaluate the associations between sex hormone status, metabolic risk parameters, obesity and distribution of adipose tissue, 25 premenopausal women with a wide range of body mass index (19.3–48.1 kg/m2 were studied. Body composition was determined by dual-energy x-ray absorptiometry scan and anthropometric measurements; in addition, lipid and sex hormone status were determined and an oral glucose tolerance test was performed. We found that sex hormone-binding globulin was correlated negatively with total fat mass (r = –0.77, p < 0.001) and especially with abdominal localization of adipose tissue (r = –0.85, p < 0.001). Free testosterone was correlated positively with total fat mass (r = 0.40, p < 0.05) and with abdominal fat accumulation (r = 0.64, p < 0.001). Free estrogen was correlated negatively with total amount of adipose tissue (r = –0.40, p < 0.05) but not with the distribution of adipose tissue, Finally, total fatness, abdominal localization of adipose tissue and free testosterone were all associated with elevated metabolic risk factors. However, multiple regression analysis revealed that only abdominal localization of adipose tissue was independently associated with a higher risk profile, whereas the effects of sex hormones or total fatness disappeared when abdominal localization of adipose tissue was included in the analysis. In conclusion, these findings in premenopausal women indicate that the connection between sex hormones and metabolic risk factors might be indirect, probably operating through alterations in the amount of adipose tissue in the abdominal region. SB Pedersen, University Clinic of Endocrinology and Internal Medicine, Aarthus, Amtssygehus, Tage Hansensgade, DK-8000 Aarhus C, Denmark


2014 ◽  
Vol 23 (12) ◽  
pp. 2943-2953 ◽  
Author(s):  
Kelly A. Hirko ◽  
Donna Spiegelman ◽  
Walter C. Willett ◽  
Susan E. Hankinson ◽  
A. Heather Eliassen

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2669
Author(s):  
You Wu ◽  
Susan E. Hankinson ◽  
Stephanie A. Smith-Warner ◽  
Molin Wang ◽  
A. Heather Eliassen

Background: Flavonoids potentially exert anti-cancer effects, as suggested by their chemical structures and supported by animal studies. In observational studies, however, the association between flavonoids and breast cancer, and potential underlying mechanisms, remain unclear. Objective: To examine the relationship between flavonoid intake and sex hormone levels using timed blood samples in follicular and luteal phases in the Nurses’ Health Study II among premenopausal women. Methods: Plasma concentrations of estrogens, androgens, progesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), prolactin, and sex hormone-binding globulin (SHBG) were measured in samples collected between 1996 and 1999. Average flavonoid were calculated from semiquantitative food frequency questionnaires collected in 1995 and 1999. We used generalized linear models to calculate geometric mean hormone concentrations across categories of the intake of flavonoids and the subclasses. Results: Total flavonoid intake generally was not associated with the hormones of interest. The only significant association was with DHEAS (p-trend = 0.02), which was 11.1% (95% confidence interval (CI): −18.6%, −3.0%) lower comparing the highest vs. lowest quartile of flavonoid intake. In subclass analyses, the highest (vs. lowest) quartile of flavan-3-ol intake was associated with significantly lower DHEAS concentrations (−11.3% with 95% CI: −18.3%, −3.7%, p-trend = 0.01), and anthocyanin intake was associated with a significant inverse trend for DHEA (−18.0% with 95% CI: −27.9%, −6.7%, p-trend = 0.003). Conclusion: Flavonoid intake in this population had limited impact on most plasma sex hormones in premenopausal women. Anthocyanins and flavan-3-ols were associated with lower levels of DHEA and DHEAS.


1999 ◽  
Vol 34 (2) ◽  
pp. 133-139 ◽  
Author(s):  
Margaret C. Martini ◽  
Betsy B. Dancisak ◽  
Carol J. Haggans ◽  
William Thomas ◽  
Joanne L. Slavin

2012 ◽  
Vol 21 (11 Supplement) ◽  
pp. 77-77
Author(s):  
Scott R. Bauer ◽  
Renee T. Fortner ◽  
Margaret A. Gates ◽  
Heather Eliassen ◽  
Susan E. Hankinson ◽  
...  

Vascular ◽  
2014 ◽  
Vol 23 (3) ◽  
pp. 327-328
Author(s):  
Adem İ Diken ◽  
Adnan Yalçınkaya ◽  
Eray Aksoy ◽  
Seyhan Yılmaz ◽  
Kerim Çağlı

Primary Raynaud’s phenomenon may be insistent in patients under medical therapy, and intrauterine devices may be an unnoticed reason in these patients. Fluctuations in female sex hormone status were reported to be associated with the emergence of primary Raynaud’s phenomenon symptoms. The use of intrauterine devices was not reported to be associated with Raynaud’s phenomenon previously. Intrauterine device may stimulate vascular hyperactivity regarding hormonal or unknown mechanisms that result in Raynaud’s phenomenon. We present a postmenopausal patient who complained of primary Raynaud’s phenomenon symptoms and had recovery after the removal of her copper intrauterine device.


1998 ◽  
Vol 12 (1) ◽  
pp. 21-25 ◽  
Author(s):  
Robinson ◽  
Iqbal ◽  
Al-Azzawi ◽  
Abrams ◽  
Mayberry

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