scholarly journals Emu Oil Combined with Lyprinol™ Reduces Small Intestinal Damage in a Rat Model of Chemotherapy-Induced Mucositis

2016 ◽  
Vol 68 (7) ◽  
pp. 1171-1180 ◽  
Author(s):  
Suzanne Mashtoub ◽  
Lorrinne S Lampton ◽  
Georgina L Eden ◽  
Ker Y Cheah ◽  
Kerry A Lymn ◽  
...  
Keyword(s):  
Rat Model ◽  
Intestinal Damage ◽  
Emu Oil ◽  
Small Intestinal

scholarly journals Emu Oil Reduces Small Intestinal Inflammation in the Absence of Clinical Improvement in a Rat Model of Indomethacin-Induced Enteropathy

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Suzanne M. Abimosleh ◽  
Cuong D. Tran ◽  
Gordon S. Howarth
Keyword(s):  
Intestinal Inflammation ◽  
Activity Index ◽  
Disease Activity Index ◽  
Intestinal Damage ◽  
Sprague Dawley ◽  
Emu Oil ◽  
Sprague Dawley Rats ◽  
Nsaid Enteropathy ◽  
Small Intestinal ◽  
Normal Controls

Nonsteroidal-anti-inflammatory-drug (NSAID) enteropathy is characterized by small intestinal damage and ulceration. Emu Oil (EO) has previously been reported to reduce intestinal inflammation.Aim. We investigated EO for its potential to attenuate NSAID-enteropathy in rats.Methods. Male Sprague Dawley rats (n=10/group) were gavaged with Water, Olive Oil (OO), or EO (0.5 mL; days 0–12) and with 0.5 mL Water or the NSAID, Indomethacin (8 mg/kg; days 5–12) daily. Disease activity index (DAI), 13C-sucrose breath test (SBT), organ weights, intestinal damage severity (IDS), and myeloperoxidase (MPO) activity were assessed.P<0.05was considered significant.Results. In Indomethacin-treated rats, DAI was elevated (days 10–12) and SBT values (56%) and thymus weight (55%) were decreased, relative to normal controls. Indomethacin increased duodenum (68%), colon (24%), SI (48%), caecum (48%), liver (51%) and spleen (88%) weights, IDS scores, and MPO levels (jejunum: 195%, ileum: 104%) compared to normal controls. Jejunal MPO levels were decreased (64%) by both EO and OO, although only EO decreased ileal MPO (50%), compared to Indomethacin controls.Conclusions. EO reduced acute intestinal inflammation, whereas other parameters of Indomethacin-induced intestinal injury were not affected significantly. Increased EO dose and/or frequency of administration could potentially improve clinical efficacy.

scholarly journals Evaluation of small intestinal damage in a rat model of 6 Minutes cardiac arrest

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Daniel C. Schroeder ◽  
Alexandra C. Maul ◽  
Esther Mahabir ◽  
Isabell Koxholt ◽  
Xiaowei Yan ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Rat Model ◽  
Intestinal Damage ◽  
Small Intestinal

scholarly journals Orally administered emu oil decreases acute inflammation and alters selected small intestinal parameters in a rat model of mucositis

2010 ◽  
Vol 104 (4) ◽  
pp. 513-519 ◽  
Author(s):  
Ruth J. Lindsay ◽  
Mark S. Geier ◽  
Roger Yazbeck ◽  
Ross N. Butler ◽  
Gordon S. Howarth
Keyword(s):  
Rat Model ◽  
Alimentary Tract ◽  
Nutritional Supplement ◽  
Saline Control ◽  
Dark Agouti ◽  
Sucrase Activity ◽  
Emu Oil ◽  
Potential Benefits ◽  
Small Intestinal

Mucositis resulting from cancer chemotherapy is a serious disorder of the alimentary tract. Emu oil has demonstrated anti-inflammatory properties in animal models of arthritis and wound healing; however, its effects on the intestine remain unknown. We investigated emu oil for its potential to decrease the severity of mucositis in a rat model. Female Dark Agouti rats (110–150 g) were orogastrically gavaged with emu oil (0·5 or 1 ml) or water (1 ml) for 5 d before intraperitoneal injection of 5-fluorouracil (5-FU, 150 mg/kg) or saline (control), and this was continued up to the day of sacrifice (48, 72 and 96 h post 5-FU administration). Histological (villus height, crypt depth (CD) and disease severity score) and biochemical (myeloperoxidase (MPO) activity) parameters were determined in intestinal tissues collected at sacrifice. Sucrase activity in vivo was quantified by the sucrose breath test. Activated neutrophil activity (MPO) in the ileum was significantly decreased by emu oil (0·5 ml, 451 (sem 168) U/g and 1 ml, 503 (sem 213) U/g) compared with 5-FU-treated controls (1724 (sem 431) U/g) 96 h post 5-FU administration. There were also significant increases in CD (152 (sem 8) μm) in the ileum of rats that receivied 1 ml emu oil at 96 h compared with 5-FU-treated controls (CD (106 (sem 12) μm)). Emu oil did not affect sucrase activity. Emu oil decreased acute ileal inflammation, and improved mucosal architecture in the intestine during recovery from chemotherapy in rats. Further studies investigating the potential benefits of emu oil as a nutritional supplement for the treatment of intestinal disorders are indicated.

Mechanism underlying protection by constitutively formed nitric oxide of indodmethacin-induced small intestinal damage in rats

2001 ◽  
Vol 120 (5) ◽  
pp. A703-A703
Author(s):  
A TANAKA ◽  
H MIZOGUCHI ◽  
T MIYAZAWA ◽  
T KUNIKATA ◽  
K TAKEUCHI
Keyword(s):  
Nitric Oxide ◽  
Intestinal Damage ◽  
Small Intestinal

scholarly journals Involvement of gliadin, a component of wheat gluten, in increased intestinal permeability leading to non-steroidal anti-inflammatory drug-induced small-intestinal damage

PLoS ONE ◽  
2019 ◽  
Vol 14 (2) ◽  
pp. e0211436 ◽  
Author(s):  
Sunao Shimada ◽  
Tetsuya Tanigawa ◽  
Toshio Watanabe ◽  
Akinobu Nakata ◽  
Naoki Sugimura ◽  
...  
Keyword(s):  
Intestinal Permeability ◽  
Wheat Gluten ◽  
Intestinal Damage ◽  
Drug Induced ◽  
Inflammatory Drug ◽  
Small Intestinal ◽  
Anti Inflammatory

Emu oil expedites small intestinal repair following 5-fluorouracil-induced mucositis in rats

2013 ◽  
Vol 238 (11) ◽  
pp. 1305-1317 ◽  
Author(s):  
Suzanne Mashtoub ◽  
Cuong D Tran ◽  
Gordon S Howarth
Keyword(s):  
Emu Oil ◽  
Small Intestinal ◽  
Intestinal Repair

scholarly journals Lubiprostone prevents NSAID‐induced small intestinal damage via prostaglandin EP4 receptors (840.7)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Koji Takeuchi ◽  
Shusaku Hayashi ◽  
Kikuko Amagase ◽  
Naoto Kurata
Keyword(s):  
Intestinal Damage ◽  
Small Intestinal

scholarly journals Quercetin prevents small intestinal damage and enhances intestinal recovery during methotrexate-induced intestinal mucositis of rats

2018 ◽  
Vol 62 (0) ◽  
Author(s):  
Igor Sukhotnik ◽  
Dalia Moati ◽  
Ron Shaoul ◽  
Boaz Loberman ◽  
Yulia Pollak ◽  
...  
Keyword(s):  
Intestinal Damage ◽  
Intestinal Mucositis ◽  
Small Intestinal

scholarly journals Evaluation of Small Intestinal Motility in a Rat Model of Irritable Bowel Syndrome

2021 ◽  
Author(s):  
Masamichi Sato ◽  
Takahiro Kudo ◽  
Nobuyasu Arai ◽  
Reiko Kyodo ◽  
Kenji Hosoi ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Small Intestine ◽  
Real Time ◽  
Rat Model ◽  
Intestinal Motility ◽  
Restraint Stress ◽  
Rat Models ◽  
Small Intestinal Motility ◽  
Small Intestinal ◽  
Irritable Bowel

Abstract Background: The correlation between small intestinal motility alteration and irritable bowel syndrome (IBS) is not well evaluated. Aims: To assess the small intestinal and colonic transits in an IBS rat model with restraint stress and determine the role of small intestinal motility in the IBS pathophysiology.Methods: Restraint stress was utilized to make adolescent IBS rat models that were evaluated for clinical symptoms, including stool frequency and diarrhea. The small intestinal motility and transit rate were also evaluated. The amounts of mRNA encoding corticotropin-releasing hormone, mast cell, and serotonin (5-Hydroxytryptamine; 5-HT) receptor 3a were quantified using real-time polymerase chain reaction (PCR); the 5-HT expression was evaluated using immunostaining.Results: Restraint stress significantly increased the number of fecal pellet outputs, stool water content, and small intestinal motility in the IBS rat models. There was no difference in real-time PCR results, but immunostaining analysis revealed that 5-HT expression in the small intestine was significantly increased in the IBS rat models.Conclusions: In the adolescent rat model of IBS with restraint stress, we observed an increase in small intestinal and colonic motility. In the small intestine, enhanced 5-HT secretion in the distal portion may be involved in increasing the small intestinal motility.

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