Serum Vitamin D Status and Breast Cancer Risk by Receptor Status: A Systematic Review

Vitamin D (the sunshine vitamin) plays a vital role in calcium homeostasis, skeletal metabolism, and immune, cardiovascular, and reproductive systems’ functions. The worldwide prevalence of vitamin D deficiency is approximately 1 billion. Vitamin D deficiency is a serious health problem with numerous health consequences; it is associated with diabetes, rheumatic arthritis, Parkinson, Alzheimer diseases, osteomalacia, osteoporosis, and fractures in adults and cancers. Many reports showed an inverse association between serum vitamin D concentration and incidence of several cancers, including breast, colorectal, kidney, lung, and pancreatic. About 20 different cancers have incidence rates inversely related to solar UV-B doses and serum vitamin D concentration. Considering the rising incidence of breast cancer and high prevalence of vitamin D deficiency, this review aimed to reflect an association between serum vitamin D concentration and breast cancer risk, reveal the link between vitamin D receptor genetic polymorphisms and breast cancer risk, and review the relationship between vitamin D level, breast cancer risk, and prognostic factors such as tumor stage, grade, size, lymph node involvement, and hormone receptor status.

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Meta-analysis: Serum vitamin D and breast cancer risk

European Journal of Cancer ◽

10.1016/j.ejca.2010.03.037 ◽

2010 ◽

Vol 46 (12) ◽

pp. 2196-2205 ◽

Cited By ~ 140

Author(s):

Lu Yin ◽

Norma Grandi ◽

Elke Raum ◽

Ulrike Haug ◽

Volker Arndt ◽

...

Keyword(s):

Breast Cancer ◽

Vitamin D ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Meta Analysis ◽

Serum Vitamin ◽

Serum Vitamin D

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Serum vitamin D status and in vitro fertilization outcomes: a systematic review and meta-analysis

Archives of Gynecology and Obstetrics ◽

10.1007/s00404-016-4058-1 ◽

2016 ◽

Vol 293 (6) ◽

pp. 1339-1345 ◽

Cited By ~ 20

Author(s):

Shi Shi Lv ◽

Ji Ying Wang ◽

Xiao Qian Wang ◽

Yan Wang ◽

Yong Xu

Keyword(s):

Systematic Review ◽

Vitamin D ◽

In Vitro Fertilization ◽

Meta Analysis ◽

Serum Vitamin ◽

Vitamin D Status ◽

Vitro Fertilization ◽

Serum Vitamin D

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Serum vitamin D status and metabolic syndrome: a systematic review and dose-response meta-analysis

Nutrition Research and Practice ◽

10.4162/nrp.2021.15.3.329 ◽

2021 ◽

Vol 15 (3) ◽

pp. 329

Author(s):

Kyueun Lee ◽

Jihye Kim

Keyword(s):

Systematic Review ◽

Metabolic Syndrome ◽

Vitamin D ◽

Dose Response ◽

Meta Analysis ◽

Serum Vitamin ◽

Vitamin D Status ◽

Serum Vitamin D

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Prevalence of vitamin D insufficiency in Qatar: a systematic review

Journal of Public Health Research ◽

10.4081/jphr.2012.e36 ◽

2012 ◽

Vol 1 (3) ◽

pp. 36 ◽

Cited By ~ 16

Author(s):

Alaa Badawi ◽

Paul Arora ◽

Eman Sadoun ◽

Al-Anoud Al-Thani ◽

Mohamed H. Al Thani

Keyword(s):

Systematic Review ◽

Vitamin D ◽

Sample Size ◽

Serum Vitamin ◽

Weighted Average ◽

Serum Levels ◽

Vitamin D Insufficiency ◽

Vitamin D Status ◽

Serum Vitamin D ◽

Vitamin D Levels

Qatar has a high burden of chronic diseases including obesity, cardiovascular disease and type 2 diabetes mellitus. Low serum vitamin D levels have been implicated in the development and progression of a range of these chronic conditions. The prevalence of vitamin D insufficiency or deficiency in the general population of Qatar has still not been investigated. The aim of this study was to carry out a systematic review of published studies documenting the prevalence of vitamin D insufficiency or deficiency in the Qatari population. A search strategy was developed for online databases (PubMed, Ovid MEDLINE, Embase and Embase Classic) between 1980 to the last week of August 2012, and bibliographies of the included studies were further searched for additional reports. Search terms used were QATAR and VITAMIN D. Studies reporting the serum levels of vitamin D in several Qatari sub-populations were identified. Weighted-average vitamin D serum levels and prevalence of low vitamin D status (<75 nmol/L) were calculated. Subgroup analysis was carried out by age. The quality of each study was evaluated according to four criteria: national representativeness, representation of males and females, the sample size, and the sampling protocol. A total of 16 relevant publications were identified, and 8 of these (reporting from 7 unique studies) met our inclusion and exclusion criteria with a total number of 1,699 Qatari subjects. The pooled sample size weighted-average vitamin D concentration (±SD) was 45.3±14.3 nmol/L (95% CI: 44.6-46.0; range 29.2-66.9 nmol/L). The weighted-average prevalence of low vitamin D status was 90.4% (95% CI: 90.1-91.0; range 83%-91%). Age was inversely correlated with vitamin D levels and directly with its insufficiency/deficiency prevalence. There have only been a few studies on the prevalence of low vitamin D in Qatar a very high prevalence of vitamin D insufficiency/deficiency in Qatar that increases with age has been suggested. The present report underlines the need to develop a nationally representative study to further evaluate vitamin D status in Qatar. Given the growing evidence of the role of vitamin D in chronic disease, this study could help develop public health strategies for disease prevention in Qatar.

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