scholarly journals Vitamin D and Breast Cancer: Latest Evidence and Future Steps

2017 ◽  
Vol 11 ◽  
pp. 117822341774981 ◽  
Author(s):  
Manar Atoum ◽  
Foad Alzoughool
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Incidence Rates ◽  
Inverse Association ◽  
Rheumatic Arthritis ◽  
Serum Vitamin D

Vitamin D (the sunshine vitamin) plays a vital role in calcium homeostasis, skeletal metabolism, and immune, cardiovascular, and reproductive systems’ functions. The worldwide prevalence of vitamin D deficiency is approximately 1 billion. Vitamin D deficiency is a serious health problem with numerous health consequences; it is associated with diabetes, rheumatic arthritis, Parkinson, Alzheimer diseases, osteomalacia, osteoporosis, and fractures in adults and cancers. Many reports showed an inverse association between serum vitamin D concentration and incidence of several cancers, including breast, colorectal, kidney, lung, and pancreatic. About 20 different cancers have incidence rates inversely related to solar UV-B doses and serum vitamin D concentration. Considering the rising incidence of breast cancer and high prevalence of vitamin D deficiency, this review aimed to reflect an association between serum vitamin D concentration and breast cancer risk, reveal the link between vitamin D receptor genetic polymorphisms and breast cancer risk, and review the relationship between vitamin D level, breast cancer risk, and prognostic factors such as tumor stage, grade, size, lymph node involvement, and hormone receptor status.

scholarly journals Does the evidence for an inverse relationship between serum vitamin D status and breast cancer risk satisfy the Hill criteria?

2012 ◽  
Vol 4 (2) ◽  
pp. 152-157 ◽  
Author(s):  
Sharif B. Mohr ◽  
Edward D. Gorham ◽  
John E. Alcaraz ◽  
Christopher I. Kane ◽  
Caroline A. Macera ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Inverse Relationship ◽  
Serum Vitamin ◽  
Vitamin D Status ◽  
Serum Vitamin D ◽  
Hill Criteria ◽  
The Hill

scholarly journals Serum Vitamin D Status and Breast Cancer Risk by Receptor Status: A Systematic Review

2018 ◽  
Vol 70 (5) ◽  
pp. 804-820 ◽  
Author(s):  
Jessica L. Tommie ◽  
Susan M. Pinney ◽  
Laurie A. Nommsen-Rivers
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Vitamin D ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Serum Vitamin ◽  
Vitamin D Status ◽  
Receptor Status ◽  
Serum Vitamin D

Meta-analysis: Serum vitamin D and breast cancer risk

2010 ◽  
Vol 46 (12) ◽  
pp. 2196-2205 ◽  
Author(s):  
Lu Yin ◽  
Norma Grandi ◽  
Elke Raum ◽  
Ulrike Haug ◽  
Volker Arndt ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Serum Vitamin D

scholarly journals Relation of Vitamin D Deficiency with Breast Cancer Staging in Patients from INMOL Cancer Hospital

2021 ◽  
Vol 35 (1) ◽  
pp. 27-32
Author(s):  
Maleeha Tahir Butt
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Breast Carcinoma ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Stage I ◽  
Serum Vitamin D ◽  
Cancer Hospital ◽  
Vitamin D Levels ◽  
Healthy Females

Introduction: Vitamin D deficiency can be critical and is reported to be as one of the factors for development and progression of breast carcinoma. Aims & Objectives: To measure and compare 25(OH)D (calcidiol) levels in healthy females and in breast carcinoma patients in four different stages. Place and duration of study: This cross sectional study and research was conducted in Shaikh Zayed Medical Complex in the Department of Biochemistry and Chemical Pathology from Jan 2018 to Jan 2019. The patients were selected from INMOL Cancer Hospital, Lahore. Material & Methods: The study was carried out on 39 healthy females (controls) and 156 newly diagnosed cases of carcinoma breast from stage I to IV, 39 patients of each stage. 25(OH)D was determined in blood samples of patients by ADVIA Centaur (XP) immunoassay system. Results: In this study the mean 25(OH)D level of healthy females with mean age of 41.7 ± 15.8 years, was 25.1 ± 5.5ng/ml. 25(OH) D level of breast cancer patients was found to be decreasing with stage progression. For the stage I the average 25(OH)D level was 12.31ng/ml, stage II was 9 ng/ml, stage III was 8.3 ng/ml and stage IV was 8.4 ng/ml. Conclusion: It was found that healthy group of females had higher values of serum vitamin D levels as compared to breast carcinoma patients. Low concentration of serum vitamin D may contribute to the progression of stage of breast carcinoma.

scholarly journals Serum 25(OH) Vitamin D Deficiency and Risk of Breast Cancer in Malaysia: A Case-Control Study

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 23s-23s
Author(s):  
A.H. Asmali Jauhari ◽  
N. Bhoo-Pathy ◽  
T. Islam ◽  
M.Y. Jalaludin ◽  
F.M. Moy ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cohort Study ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Vitamin D Deficiency ◽  
Case Control Study ◽  
Case Control ◽  
Kuala Lumpur ◽  
Control Study

Background: Despite the emerging literature supporting the beneficial role of sufficient vitamin D level and its association with various cancers, current evidence on the vitamin D and the risk of getting breast cancer is still inconsistent. Furthermore, the study between vitamin D status and breast cancer risk among south east Asian women is limited. Aim: We aimed to investigate the association between vitamin D deficiency and the risk of getting breast cancer among Malaysian women. Methods: We conducted a retrospective nested case control study which consisted of Malaysian Breast Cancer Cohort Study (MyBCC) subjects as the cases and UMMC Mammogram Cohort Study subjects as the hospital control. We also used a secondary data from the Cohort Study on Clustering of Lifestyle Risk Factors and understanding its association with stress on health and well-being among school teachers in Malaysia (CLUSTer), as we only included the data from the schools in Kuala Lumpur as the population control. We measured and compared serum 25-hydroxyvitamin D (25(OH)D) between newly diagnosed breast cancer patients (n= 231), female without cancer who came for mammogram checkup (n= 462) and female teachers without cancer from schools in Kuala Lumpur (n=231). Vitamin D deficiency was defined as serum (25(OH)D) < 50 nmol/L. Results: Median serum (25(OH)D) for cases and controls were 42.43 nmol/L and 44.30 nmol/L, respectively. We examined the association between serum (25(OH)D) and breast cancer risk stratified by age < 50 and ≥ 50 years old. The crude ORs for breast cancer risk in cases and controls did not show statistically significant association with serum (25(OH)D) for both age groups ( P = 0.463 and P = 0.650, respectively). After adjustment for age, ethnicity, education level and BMI the ORs (95% CI) for breast cancer risk among both groups were 1.183 (0.591-2.366) ( P = 0.635) and 1.237 (0.801-1.911) ( P = 0.338) respectively for women with serum (25(OH)D) < 50 nmol/L. Conclusion: Our results suggest that there is lack of association between vitamin D deficiency and the risk of getting breast cancer in Malaysian women.

scholarly journals The effect of vitamin D on the development and course of breast cancer (literature review)

2021 ◽  
Vol 4 (1) ◽  
pp. 19-29
Author(s):  
M.V. Pavlushenko ◽  
R.V. Lyubota ◽  
O.S. Zotov ◽  
M.F. Anikusko ◽  
R.I. Vereshchako
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Prognostic Factors ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Treatment Outcomes ◽  
Vitamin D Deficiency ◽  
Vitamin D Receptor ◽  
Receptor Status ◽  
The Relationship

Breast cancer is the most common cancer among the female population worldwide. The incidence of breast cancer is increasing every year. This requires the search for new trigger factors that can contribute to the onset and course of this disease. One of these factors is vitamin D, which is constantly deficient in most of the world’s population. This article provides a review of clinical studies over the last 15 years on the relationship between serum vitamin D concentration and breast cancer risk, prognostic factors, survival and treatment outcomes, and the effect of vitamin D receptor status on breast cancer. Studies have shown heterogeneity in research results that found the relationship between low vitamin D levels and breast cancer risk, prognostic factors and survival. There was no heterogeneity in studies showing an association between decreased vitamin D receptor status and worse prognosis. The situation was similar when studying the effect of vitamin D on impro­ving treatment outcomes. Despite conflicting research results, most studies show a correlation between vitamin D deficiency and breast cancer risk, prognostic factors, survival and treatment outcomes. Therefore, the selected vector of scientific researches is rational both from the point of view of eliminating the pandemic of vitamin D deficiency among the world’s population and preventing the spread of breast cancer.

scholarly journals Association of Vitamin D Deficiency and Inflammatory Cytokines with the Clinicopathological Features of Breast Cancer in Female Saudi Patients

2021 ◽  
Author(s):  
Amal F. Gharib ◽  
Ahmad El Askary ◽  
Mazen Almehmadi ◽  
Wael H. Elsawy ◽  
Hatem H. Allam ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Inflammatory Cytokines ◽  
Cancer Progression ◽  
Serum Vitamin ◽  
Axillary Lymph ◽  
Serum Vitamin D ◽  
Tnf Α ◽  
Saudi Patients

Abstract Background: Breast cancer is considered to be the most common leading cause of cancer related death among women in Saudi Arabia. Many researches supposed a strong correlation between vitamin D and different types of cancer. Patients and methods: We aimed to study the implication of serum vitamin D, calcium, interleukin 6 (IL6), tumor necrosis factor alpha (TNF-α) and chemerin on progression of breast cancer. One hundred female Saudi patients were included in the current research and we assessed their serum levels of vitamin D, calcium, IL-6, TNF-α and chemerin. Results: vitamin D was significantly decreased in tumors with high grade (P < 0.0001), patients with obesity (P = 0.013), negative estrogen receptors (ER) (P < 0.0001), negative progesterone receptors (PR) (P < 0.0001) and positive HER2 receptors (P < 0.0001). It was also decreased in large tumors (P < 0.0001), patients with axillary lymph node involvement (P < 0.0001) and in the patients with advanced clinical stage (P < 0.0001). Moreover, higher levels of serum IL-6, TNF-α, chemerin were significantly related to breast cancer and its advanced stages. Conclusion: vitamin D deficiency and elevated inflammatory cytokines (IL6, TNF-α and chemerin) are associated with breast cancer progression in female Saudi patients.

scholarly journals Assessing vitamin D and mammographic breast density in Alaskan women

2020 ◽  
Vol 10 (4) ◽  
Author(s):  
Narjust Duma ◽  
Ivana Croghan ◽  
Sarah Jenkins ◽  
Celine Vachon ◽  
Loni Neal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Breast Density ◽  
Pearson Correlation ◽  
Serum Vitamin ◽  
Mammographic Breast Density ◽  
Serum Vitamin D ◽  
Populations At Risk ◽  
Vitamin D Levels

Vitamin D deficiency and high breast density may be associated with increased breast cancer risk. We examined a possible association between vitamin D levels and mammographic breast density in a population of Alaskan women. Patients seen in the Mayo Clinic-Alaska Native Medical Center telemedicine program from December 2014 to December 2017 were enrolled in the study. Pearson correlation was used to estimate the association between mammographic breast density and vitamin D levels. Of the 33 women enrolled, 70% of women self-identified as American Indian/Alaskan Native, 12% as White, 6% as Native Hawaiian/Pacific Islander and 12% as other. Nineteen (58%) participants were taking vitamin D supplementation. No correlation was identified between breast density and serum vitamin D levels overall (correlation= –0.03). Larger studies controlling for vitamin supplementation are needed, as this association could potentially impact breast cancer rates in populations at risk for vitamin D deficiency.

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