Use of Occupation-Based Outcome Measure and Strength-Based Self-Report with Persons with Substance Use Disorders: A Prospective Cohort Study

ObjectivesIn Ethiopia, little is known about the association between substance use disorders and adherence to antituberculosis (anti-TB) medications. Therefore, the objective of this study was to assess the effect of substance use disorders on adherence to anti-TB medications in Southwest Ethiopia.DesignProspective cohort study.SettingsPatients were recruited from 22 health centres and four hospitals in Southwest Ethiopia.ParticipantsThis study was conducted among 268 patients with TB, aged 18–80 in Southwest Ethiopia between October 2017 and October 2018. At baseline, patients who were exposed substance use disorders (134 patients) and unexposed to substance use disorders (134 patients) were recruited. Patients were followed for 6 months, and data were collected on three occasions.Main outcome measureAdherence to anti-TB medications.ResultsPatients with substance use disorders had consistently higher prevalence of non-adherence than those without, 16.4% versus 3.0% at baseline, 41.7% versus 14.4% at 2-month follow-up and 45.7% versus 10.8% at 6-month follow-up assessments. Patients with khat use disorder were 3.8 times more likely to be non-adherent to anti-TB medications than patients without khat use disorder (Adjusted odds ratio (aOR)=3.8, 95% CI 1.8 to 8.0). Patients who had alcohol use disorder (AUD) were also 3.2 times likely to have poor adherence compared with their counterparts (aOR=3.2, 95% CI 1.6 to 6.6). In addition, being educated (aOR=4.4, 95% CI 1.7 to 11.3), and being merchant (aOR=6.1, 95% CI 1.2 to 30.8) were associated with non-adherence to anti-TB medications.ConclusionKhat and AUDs predict greater likelihood of non-adherence to anti-TB medication. This implies the need to integrate the management for substance use disorders into the existing TB treatment services.

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Mortality, cause of death and risk factors in patients with alcohol use disorder alone or poly-substance use disorders: a 19-year prospective cohort study

BMC Psychiatry ◽

10.1186/s12888-019-2077-8 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 6

Author(s):

Arne Jan Hjemsæter ◽

Jørgen G. Bramness ◽

Robert Drake ◽

Ivar Skeie ◽

Bent Monsbakken ◽

...

Keyword(s):

Risk Factors ◽

Substance Use ◽

Cohort Study ◽

Alcohol Use ◽

Substance Use Disorders ◽

Cause Of Death ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Alcohol Use Disorder

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Direct Thrombin Inhibitor (Dti) vs. Aspirin in Primary Total Hip and Knee Replacement Using Wound Ooze as the Primary Outcome Measure. A Prospective Cohort Study

Hip International ◽

10.5301/hip.2012.9058 ◽

2012 ◽

Vol 22 (1) ◽

pp. 22-27 ◽

Cited By ~ 14

Author(s):

Alexander L. Aquilina ◽

Luke R. Brunton ◽

Michael R. Whitehouse ◽

Niall Sullivan ◽

Ashley W. Blom

Keyword(s):

Cohort Study ◽

Knee Replacement ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Primary Outcome ◽

Outcome Measure ◽

Primary Outcome Measure ◽

Direct Thrombin Inhibitor ◽

Thrombin Inhibitor ◽

Total Hip

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Changes in quality of life, healthcare use, and substance use in HIV/hepatitis C coinfected patients after hepatitis C therapy: a prospective cohort study

HIV Clinical Trials ◽

10.1179/501100000024 ◽

2015 ◽

Vol 16 (3) ◽

pp. 100-110 ◽

Cited By ~ 16

Author(s):

Man Wah Yeung ◽

Jim Young ◽

Erica Moodie ◽

Kathleen C. Rollet-Kurhajec ◽

Kevin Schwartzman ◽

...

Keyword(s):

Quality Of Life ◽

Substance Use ◽

Cohort Study ◽

Hepatitis C ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Healthcare Use ◽

Hepatitis C Therapy

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Development and Preliminary Validation of the Patient-Reported Outcome Measure for Vascular Malformation Questionnaire: A Prospective Cohort Study

Journal of Vascular and Interventional Radiology ◽

10.1016/j.jvir.2021.01.263 ◽

2021 ◽

Author(s):

Ryan W. England ◽

Mina Motaghi ◽

Beatriz Kohler ◽

Thomas E. Hemmingson ◽

Albert W. Wu ◽

...

Keyword(s):

Cohort Study ◽

Prospective Cohort Study ◽

Vascular Malformation ◽

Prospective Cohort ◽

Outcome Measure ◽

Patient Reported Outcome ◽

Patient Reported Outcome Measure ◽

Preliminary Validation ◽

Patient Reported

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Performance-Enhancing Substance Use and Criminal Offending: A 15-Year Prospective Cohort Study

Drug and Alcohol Dependence ◽

10.1016/j.drugalcdep.2021.108832 ◽

2021 ◽

pp. 108832

Author(s):

Kyle T. Ganson ◽

Alexander Testa ◽

Dylan B. Jackson ◽

Jason M. Nagata

Keyword(s):

Substance Use ◽

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Criminal Offending ◽

Performance Enhancing

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Determining universal processes related to best outcome in emergency abdominal surgery: a multicentre, international, prospective cohort study

BMJ Open ◽

10.1136/bmjopen-2014-006239 ◽

2014 ◽

Vol 4 (10) ◽

pp. e006239 ◽

Cited By ~ 7

Author(s):

Aneel Bhangu ◽

J Edward Fitzgerald ◽

Stuart Fergusson ◽

Chetan Khatri ◽

Hampus Holmer ◽

...

Keyword(s):

Cohort Study ◽

Abdominal Surgery ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Outcome Measure ◽

Secondary Outcome ◽

Secondary Outcome Measure ◽

Perioperative Mortality ◽

Acute Surgery ◽

Emergency Abdominal Surgery

IntroductionEmergency abdominal surgery outcomes represent an internationally important marker of healthcare quality and capacity. In this study, a novel approach to investigating global surgical outcomes is proposed, involving collaborative methodology using ‘snapshot’ clinical data collection over a 2-week period. The primary aim is to identify internationally relevant, modifiable surgical practices (in terms of modifiable process, equipment and clinical management) associated with best care for emergency abdominal surgery.Methods and analysisThis is a multicentre, international, prospective cohort study. Any hospital in the world performing acute surgery can participate, and any patient undergoing emergency intraperitoneal surgery is eligible to enter the study. Centres will collect observational data on patients for a 14-day period during a 5-month window and required data points will be limited to ensure practicality for collaborators collecting data. The primary outcome measure is the 24 h perioperative mortality, with 30-day perioperative mortality as a secondary outcome measure. During registration, participants will undertake a survey of available resources and capacity based on the WHO Tool for Situational Analysis.Ethics and disseminationThe study will not affect clinical care and has therefore been classified as an audit by the South East Scotland Research Ethics Service in Edinburgh, Scotland. Baseline outcome measurement in relation to emergency abdominal surgery has not yet been undertaken at an international level and will provide a useful indicator of surgical capacity and the modifiable factors that influence this. This novel methodological approach will facilitate delivery of a multicentre study at a global level, in addition to building international audit and research capacity.Trial registration numberThe study has been registered with ClinicalTrials.gov (Identifier: NCT02179112).

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