Grape seed extract protects against amiodarone - induced nephrotoxicity and ultrastructural alterations associated with the inhibition of biomarkers of inflammation and oxidative stress in rats

2021 ◽  
pp. 1-10
Author(s):  
Refaat A. Eid ◽  
Mohamed Samir Ahmed Zaki ◽  
Mubarak Al-Shraim ◽  
Muhammad Alaa Eldeen ◽  
Mohamed A. Haidara
Keyword(s):  
Oxidative Stress ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Ultrastructural Alterations ◽  
And Oxidative Stress

scholarly journals Pre-Treatment with Grape Seed Extract Reduces Inflammatory Response and Oxidative Stress Induced by Helicobacter pylori Infection in Human Gastric Epithelial Cells

Antioxidants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 943
Author(s):  
Jose Manuel Silvan ◽  
Alba Gutierrez-Docio ◽  
Esperanza Guerrero-Hurtado ◽  
Lucia Domingo-Serrano ◽  
Ana Blanco-Suarez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Helicobacter Pylori ◽  
Epithelial Cells ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Gastric Epithelial Cells ◽  
Pre Treatment ◽  
H Pylori ◽  
And Oxidative Stress

Helicobacter pylori (H. pylori) is a pathogenic bacteria identified as a potential risk factor for gastritis, gastric ulcers and gastric cancer. During the stomach colonization, H. pylori triggers a strong inflammatory response and subsequent oxidative stress, which are associated with tissue damage. For this reason, it is of particular interest to develop alternative natural tools that enable modulation of the associated damaging immune response. With this purpose, we obtained grape seed extract (GSE) from sweet (not fermented) food grade seeds. The aim of our study was to investigate the effect of GSE and its two enriched procyanidins fractions (OPC and PPC) on the inflammatory process and oxidative stress produced by different H. pylori strains in human gastric epithelial cells (AGS). Anti-inflammatory activity was evaluated by measuring the level of interleukin-8 (IL-8) secretion. IL-8 production was significantly reduced in H. pylori-infected human gastric epithelial cells pre-treated with GSE or its enriched fractions when compared with non-pre-treated infected cells (from 21.6% to 87.8%). Pre-treatment with GSE or its fractions significantly decreased intracellular reactive oxygen species (ROS) production in AGS cells after infection, depending on the H. pylori strain. Our results also showed that GSE and its fractions demonstrate antibacterial activity against all strains of H. pylori used in the study. This work demonstrates the effectiveness of GSE enriched in procyanidins against the main events associated with H. pylori infection.

Grape seed extract reduces oxidative stress and fibrosis in experimental biliary obstruction

2007 ◽  
Vol 22 (6) ◽  
pp. 885-892 ◽  
Author(s):  
Ender Dulundu ◽  
Yahya Ozel ◽  
Umit Topaloglu ◽  
Hale Toklu ◽  
Feriha Ercan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Biliary Obstruction ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract
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