Sudden Cardiac Death not Related to Coronary Atherosclerosis

2006 ◽  
Vol 34 (1) ◽  
pp. 52-57 ◽  
Author(s):  
Elena Ladich ◽  
Renu Virmani ◽  
Allen Burke
Keyword(s):  
United States ◽  
Cardiovascular Diseases ◽  
Sudden Cardiac Death ◽  
Cardiac Disease ◽  
Cardiac Death ◽  
Coronary Atherosclerosis ◽  
The United States ◽  
Cardiac Diseases ◽  
Cardiac Events ◽  
Myocardial Diseases

Sudden cardiac death (SCD) accounts for approximately 300,000 cardiac events in the United States each year, representing an overall incidence of 0.1–0.2% per year. Although the vast majority of these may be attributed to coronary atherosclerosis, a wide variety of nonatherosclerotic-related cardiac diseases have been associated with SCD. This review highlights three general categories of cardiac disease not related to atherosclerosis: the cardiomyopathies, inflammatory myocardial diseases, and ion channel disorders. The important role played by genetics in some of these cardiovascular diseases is presented as well as toxic and drug-related etiologies.

scholarly journals B-AB08-01 SUDDEN CARDIAC DEATH IN THE YOUNG IN THE UNITED STATES FROM 2015 TO 2018

Heart Rhythm ◽  
2021 ◽  
Vol 18 (8) ◽  
pp. S13-S14
Author(s):  
Kristin M. Burns ◽  
Michelle Udine ◽  
Esther Shaw ◽  
Meghan Faulkner ◽  
Erik Buczkowski ◽  
...  
Keyword(s):  
United States ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
The United States

scholarly journals Public Health Burden of Sudden Cardiac Death in the United States

2014 ◽  
Vol 7 (2) ◽  
pp. 212-217 ◽  
Author(s):  
Eric C. Stecker ◽  
Kyndaron Reinier ◽  
Eloi Marijon ◽  
Kumar Narayanan ◽  
Carmen Teodorescu ◽  
...  
Keyword(s):  
Public Health ◽  
United States ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
The United States ◽  
Public Health Burden ◽  
Health Burden

scholarly journals Preventing sudden cardiac death in young athletes – A perspective from the United States

2021 ◽  
Vol 11 ◽  
pp. 100054
Author(s):  
Jamario Skeete ◽  
Gatha Nair ◽  
Henry D. Huang ◽  
Annabelle Santos Volgman ◽  
Melissa Tracy
Keyword(s):  
United States ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
The United States ◽  
Young Athletes

scholarly journals Diagnostic yield in victims of sudden cardiac death and their relatives

EP Europace ◽  
2020 ◽  
Vol 22 (6) ◽  
pp. 964-971 ◽  
Author(s):  
Benjamin Lautrup Hansen ◽  
Elisabeth Mütze Jacobsen ◽  
Amalie Kjerrumgaard ◽  
Jacob Tfelt-Hansen ◽  
Bo Gregers Winkel ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Cardiac Disease ◽  
Cardiac Death ◽  
Cardiovascular Events ◽  
Diagnostic Yield ◽  
Arrhythmogenic Right Ventricular Cardiomyopathy ◽  
Cardiac Events ◽  
Common Diagnosis ◽  
Inherited Cardiac Disease ◽  
Low Rate

Abstract Aims International guidelines recommend cardiogenetic screening in families with sudden cardiac death (SCD) if the suspected cause is an inherited cardiac disease. The aim was to assess the diagnostic yield of inherited cardiac diseases in consecutively referred SCD families. Methods and results In this single-centre retrospective study, we consecutively included families referred to our tertiary unit between 2005 and 2018 for screening due to SCD. Following evaluation of premortem medical records and postmortem findings for the proband, the families underwent a guideline-based screening protocol. Relatives were followed and cardiovascular events registered. In total, 304 families with 695 relatives were included. In probands, mean age at death was 39 years (75% males) and in relatives mean age at screening was 35 years (47% males). The proband-diagnosis was established through autopsy findings (n = 89), genetic analyses (n = 7), or based on premortem findings (n = 21). In the remaining 187 families with borderline/no diagnosis in the proband, screening of relatives yielded a diagnosis in 26 additional families. In total, an inherited cardiac disease was identified in 143 out of 304 families (47%). In relatives, 73 (11%) were diagnosed. Arrhythmogenic right ventricular cardiomyopathy (n = 16) was the most common diagnosis. During follow-up (mean 5.5 years), a low rate of serious cardiac events was observed (no SCD events). Conclusion Forty-seven percent of SCD families were diagnosed. Eleven percent of the screened relatives received a definite diagnosis and were offered treatment according to guidelines. A low rate of serious cardiovascular events was observed among SCD relatives.

scholarly journals Sudden Cardiac Death Risk Distribution in the United States Population (from NHANES, 2005 to 2012)

2019 ◽  
Vol 123 (8) ◽  
pp. 1249-1254 ◽  
Author(s):  
Kristoff A. Olson ◽  
Ravi B. Patel ◽  
Faraz S. Ahmad ◽  
Hongyan Ning ◽  
Brittany M. Bogle ◽  
...  
Keyword(s):  
United States ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
The United States ◽  
Death Risk ◽  
United States Population ◽  
Risk Distribution ◽  
Sudden Cardiac Death Risk

P2830Clinical and genetic findings in relatives to young sudden cardiac death victims without post-mortem examination (autopsy)

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
A Kjerrumgaard ◽  
E M Jacobsen ◽  
B L Hansen ◽  
B G Winkel ◽  
A H Christensen ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Cardiac Disease ◽  
Cardiac Death ◽  
Diagnostic Yield ◽  
Cardiac Diseases ◽  
Post Mortem ◽  
Definite Diagnosis ◽  
Cardiac Work ◽  
Borderline Diagnosis ◽  
Work Up

Abstract Background Guidelines recommend clinical assessment of relatives to young sudden cardiac death (SCD) victims (<50 years) to protect the surviving relatives by pre-symptomatic interventions, in case the SCD was due to an inherited cardiac disorder. The etiology is an inherited cardiac disease in about 50% of young SCD cases. The work-up of relatives is generally guided by findings in the SCD victim. If post-mortem examinations (autopsies) have not been performed the work-up of relatives is challenged. The diagnostic hit-ratio of screening of relatives under these circumstances is unclear. Purpose To assess the diagnostic yield of inherited cardiac diseases of cardiac work-up in relatives of SCD victims, where no autopsy had been performed. Methods This retrospective study consecutively included families referred to our tertiary referral centre, specialised in hereditary cardiac diseases, during the period 2005 to 2018 due to SCD in the family. No autopsy had been performed in any of the SCD victims. The relatives underwent standard cardiac work-up according to guidelines. Based on the findings in the relatives the families were categorised into: 1) definite diagnosis, 2) borderline diagnosis or 3) undiagnosed. Results We assessed 149 relatives (43±16 age, 48% men) to 84 SCD un-autopsied cases (44±11 age, 79% men). In 11 (13%) families a definite diagnosis was established, in 8 (10%) families a borderline diagnosis was found and the remaining 65 (77%) families remained undiagnosed. The most common diagnosis was premature IHD (36%) followed by cardiomyopathies (27%) and channelopathies (27%). A disease-causing mutation was identified in 3 families out of 15 genetically examined families. Conclusion Systematic cardiac work-up of relatives to not-autopsied SCD victims, revealed a definite hereditary cardiac disease in 13% of the referred families, and a borderline diagnosis in additionally 10% of the families. Despite a reduced diagnostic yield in family members of non-autopsied SCD victims, work-up of relatives is clearly still justified.

scholarly journals INCIDENCE OF SUDDEN CARDIAC DEATH ASSOCIATED WITH PHYSICAL EXERTION IN THE UNITED STATES MILITARY

2015 ◽  
Vol 65 (10) ◽  
pp. A295
Author(s):  
Samuel O. Jones ◽  
Darlene Smallman ◽  
Bryant J. Webber ◽  
Ann I. Scher ◽  
Edward L. Mazuchowski ◽  
...  
Keyword(s):  
United States ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Physical Exertion ◽  
The United States ◽  
United States Military

scholarly journals Sudden Cardiac Death Among Firefighters ≤45 Years of Age in the United States

2013 ◽  
Vol 112 (12) ◽  
pp. 1962-1967 ◽  
Author(s):  
Justin Yang ◽  
Dennis Teehan ◽  
Andrea Farioli ◽  
Dorothee M. Baur ◽  
Denise Smith ◽  
...  
Keyword(s):  
United States ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
The United States
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