scholarly journals Age- and Sex-Related Differences in Spontaneous Hemorrhage and Fibrosis of the Pancreatic Islets in Sprague–Dawley Rats

2007 ◽  
Vol 35 (3) ◽  
pp. 388-394 ◽  
Author(s):  
Masako Imaoka ◽  
Hiroshi Satoh ◽  
Kazuhisa Furuhama
Keyword(s):  
Pancreatic Islets ◽  
Sprague Dawley ◽  
Spontaneous Hemorrhage ◽  
Sprague Dawley Rats ◽  
Age And Sex

Moderate hypothermia induces a preferential increase in pancreatic islet blood flow in anesthetized rats

2007 ◽  
Vol 293 (3) ◽  
pp. R1438-R1443 ◽  
Author(s):  
Michael Hultström ◽  
Leif Jansson ◽  
Birgitta Bodin ◽  
Örjan Källskog
Keyword(s):  
Blood Flow ◽  
Pancreatic Islets ◽  
Blood Perfusion ◽  
Moderate Hypothermia ◽  
Sprague Dawley ◽  
External Cooling ◽  
Sprague Dawley Rats ◽  
Organ Specific ◽  
Different Levels ◽  
Complex Organ

The aim of the study was to characterize the effects of induced moderate hypothermia on splanchnic blood flow, with particular reference to that of the pancreas and the islets of Langerhans. We also investigated how interference with the autonomic nervous system at different levels influenced the blood perfusion during hypothermia. For this purpose, hypothermia (body temperature of 28°C) was induced by external cooling, whereas normothermic (37.5°C) anesthetized Sprague-Dawley rats were used as controls. Some rats were pretreated with either propranolol, yohimbine, atropine, hexamethonium, or a bilateral abdominal vagotomy. Our findings suggest that moderate hypothermia elicits complex, organ-specific circulatory changes, with increased perfusion noted in the pylorus, as well as the whole pancreas and the pancreatic islets. The pancreatic islets maintain their high blood perfusion through mechanisms involving both sympathetic and parasympathetic mediators, whereas the increased pyloric blood flow is mediated through parasympathetic mechanisms. Renal blood flow was decreased, and this can be prevented by ganglionic blockade and is also influenced by β-adrenoceptors.

Influence of age and sex on the concentrations of thyroid hormone in serum in the rat

1982 ◽  
Vol 93 (2) ◽  
pp. 177-181 ◽  
Author(s):  
Joseph Segal ◽  
B. R. Troen ◽  
S. H. Ingbar
Keyword(s):  
Thyroid Hormone ◽  
Age Groups ◽  
Sprague Dawley ◽  
Age Related ◽  
Sprague Dawley Rats ◽  
Total Thyroxine ◽  
Thyroid Hormone Concentration ◽  
Dependent Processes ◽  
Age And Sex

Studies of the influence of age and sex on the concentrations of total thyroxine (T4) and 3,5,3′-tri-iodothyronine (T3) in serum and on the free T4 and free T3 indices, were conducted in Sprague–Dawley rats of the CD strain varying in age between 10 days and 12 months. Both sex- and age-related differences were found. In all age-groups studied, serum T4 concentrations were higher in the male than in the female, whereas serum T3 concentrations were higher in the female. In both sexes, concentrations of T4 and T3 in serum reached a peak early in life, between the first and second month of age, and declined thereafter. In addition, in both sexes the intensity of thyroid hormone binding, as judged from values of the in-vitro uptake of T3, did not change with age, suggesting that free T4 and T3 concentrations in the serum display the same sex differences and age-related changes as do the concentrations of total T4 and T3. It remains to be determined whether these sex-and age-related alterations in serum thyroid hormone concentration are expressed in differences in the activity of various thyroid hormone-dependent processes.

scholarly journals Echocardiographic parameters in different age and sex of Sprague-Dawley rats under isoflurane anesthesia

2021 ◽  
Vol 20 (1) ◽  
pp. 117-131
Author(s):  
Pitipat Kitpipatkun ◽  
◽  
Catthareya Sukwan ◽  
Keyword(s):  
Ejection Fraction ◽  
Male Rats ◽  
Sprague Dawley ◽  
Ejection Time ◽  
Cardiovascular Research ◽  
Mitral Inflow ◽  
Sprague Dawley Rats ◽  
Echocardiographic Parameters ◽  
Fractional Shortening ◽  
Age And Sex

Echocardiography is a useful technique for diagnosing cardiovascular disease that is safe, reproducible and accurate. A comprehensive understanding of echocardiographic parameters in different age and sex is useful for cardiovascular study. Thirty Sprague-Dawley rats of both sexes at different age underwent repetitive echocardiography. The characteristics of early and late diastolic waves through the mitral inflow depend on the heart rate. The rats had fast heart rates, with early and late diastolic Doppler flows commonly fused. Several parameters in male rats were higher than in females except for ejection fraction, fractional shortening, isovolumetric relaxation time, pre-ejection fraction and ejection time that did not differ. Different age, sex, breed and anesthesia protocol can all cause diverse results. Rat echocardiography can be potentially used as a model for human cardiovascular research. Results revealed changes in echocardiographic parameters in different age and sex to better understand normal cardiovascular functions in rat model

scholarly journals Pancreatic Islets Accumulate Cadmium in a Rodent Model of Cadmium-Induced Hyperglycemia

2020 ◽  
Vol 22 (1) ◽  
pp. 360
Author(s):  
Ryan Fitzgerald ◽  
Andrew Olsen ◽  
Jessica Nguyen ◽  
Winifred Wong ◽  
Malek El Muayed ◽  
...  
Keyword(s):  
Pancreatic Islets ◽  
Insulin Release ◽  
Fasting Blood Glucose ◽  
Pancreatic Tissue ◽  
Experimental Models ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Low Glucose

Cadmium (Cd) is an anthropogenic as well as a naturally occurring toxicant associated with prediabetes and T2DM in humans and experimental models of Cd exposure. However, relatively few studies have examined the mechanism(s) of Cd-induced hyperglycemia. The purpose of this study was to examine the role of pancreatic islets in Cd-induced hyperglycemia. Male Sprague–Dawley rats were given daily subcutaneous doses of Cd at 0.6 mg/kg over 12 weeks. There was a resulting time-dependent increase in fasting blood glucose and altered insulin release in vitro. Islets isolated from control (saline-treated) and Cd-treated animals were incubated in low (0.5 mg/mL) or high (3 mg/mL) glucose conditions. Islets from 12 week Cd-treated animals had significantly less glucose-stimulated insulin release compared to islets from saline-treated control animals. The actual Cd content of isolated islets was 5 fold higher than the whole pancreas (endocrine + exocrine) and roughly 70% of that present in the renal cortex. Interestingly, islets isolated from Cd-treated animals and incubated in high glucose conditions contained significantly less Cd and zinc than those incubated in low glucose. These results show that within whole pancreatic tissue, Cd selectively accumulates in pancreatic islets and causes altered islet function that likely contributes to dysglycemia.

scholarly journals Reference database of the main physiological parameters in Sprague-Dawley rats from 6 to 32 months

1998 ◽  
Vol 32 (4) ◽  
pp. 457-466 ◽  
Author(s):  
C. L. Alemáan ◽  
R. M. Más ◽  
I. Rodeiro ◽  
M. Noa ◽  
C. Hernández ◽  
...  
Keyword(s):  
Body Weight ◽  
Body Weight Gain ◽  
Serum Biochemistry ◽  
Exploratory Activity ◽  
Reference Database ◽  
Sprague Dawley ◽  
Hot Plate ◽  
Sprague Dawley Rats ◽  
Neoplastic Lesions ◽  
Age And Sex

A reference database comprising body weight gain, exploratory activity, hot plate response, serum biochemistry, haematology, organ weight (%) and a complete anatomopathological study containing non-neoplastic and neoplastic lesions over 1200 Sprague-Dawley rats from 6 to 32 months is described. Comparisons between age and sex were analysed.

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