Non-small cell lung cancer tumour antigen, MUC-1 peptide-loaded non-aggregated poly (lactide-co-glycolide) nanoparticles augmented cellular uptake in mouse professional antigen-presenting cells: optimisation and characterisation

2019 ◽  
Vol 37 (1) ◽  
pp. 14-28 ◽  
Author(s):  
Kiran Jyoti ◽  
Sanyog Jain ◽  
Om Prakash Katare ◽  
Anju Katyal ◽  
Ramesh Chandra ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cellular Uptake ◽  
Cell Lung Cancer ◽  
Antigen Presenting Cells ◽  
Small Cell ◽  
Tumour Antigen ◽  
Small Cell Lung ◽  
Antigen Presenting

scholarly journals The Immune Microenvironment in Brain Metastases of Non-Small Cell Lung Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Lumeng Luo ◽  
Peiyi Liu ◽  
Kuaile Zhao ◽  
Weixin Zhao ◽  
Xiaofei Zhang
Keyword(s):  
Lung Cancer ◽  
Brain Metastases ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Immune Microenvironment ◽  
The Difference ◽  
Antigen Presenting ◽  
Comprehensive Study

Brain metastasis of non-small cell lung cancer is associated with poor survival outcomes and poses rough clinical challenges. At the era of immunotherapy, it is urgent to perform a comprehensive study uncovering the specific immune microenvironment of brain metastases of NSCLC. The immune microenvironment of brain is distinctly different from microenvironments of extracranial lesions. In this review, we summarized the process of brain metastases across the barrier and revealed that brain is not completely immune-privileged. We comprehensively described the specific components of immune microenvironment for brain metastases such as central nervous system-derived antigen-presenting cells, microglia and astrocytes. Besides, the difference of immune microenvironment between brain metastases and primary foci of lung was particularly demonstrated.

scholarly journals Organic Anion Transporting Polypeptide 5A1 (OATP5A1) in Small Cell Lung Cancer (SCLC) Cells: Possible Involvement in Chemoresistance to Satraplatin

2011 ◽  
Vol 3 ◽  
pp. BIC.S7151 ◽  
Author(s):  
U. Olszewski-Hamilton ◽  
M. Svoboda ◽  
T. Thalhammer ◽  
V. Buxhofer-Ausch ◽  
K. Geissler ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cellular Uptake ◽  
Cell Lung Cancer ◽  
Intracellular Transport ◽  
Organic Anion ◽  
Small Cell ◽  
Small Cell Lung ◽  
Hek 293 ◽  
Organic Anion Transporting Polypeptide

Background The role of organic anion transporting polypeptide 5A1 (OATP5A1) a member of a family of drug transporters that mediate cellular uptake of drugs has not been characterized so far. Methods Gene expression levels of OATP5A1 in small cell lung cancer (SCLC) cell lines were determined by real-time qPCR and chemosensitivity of HEK-293- SLCO5A1-transfected cells to satraplatin in MTT assays. Results Significant expression of this transporter was found at the mRNA level, primarily in drug-resistant SCLC cells, and SLCO5A1-transfected HEK-293 cells showed higher resistance to satraplatin. OATP5A1 is found preferentially in cytoplasmic membranes of tumor cells, including SCLC. Conclusions OATP5A1 seems to effect intracellular transport of drugs and may participate in chemoresistance of SCLC by sequestration, rather than mediating cellular uptake. Since satraplatin failed to improve survival in SCLC patients, the relation of OATP5A1 expression to clinical drug resistance and its use as marker of chemoresistance should be further investigated.

scholarly journals Antigen-Presenting Intratumoral B Cells Affect CD4+ TIL Phenotypes in Non–Small Cell Lung Cancer Patients

2017 ◽  
Vol 5 (10) ◽  
pp. 898-907 ◽  
Author(s):  
Tullia C. Bruno ◽  
Peggy J. Ebner ◽  
Brandon L. Moore ◽  
Olivia G. Squalls ◽  
Katherine A. Waugh ◽  
...  
Keyword(s):  
Lung Cancer ◽  
B Cells ◽  
Small Cell Lung Cancer ◽  
Cancer Patients ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer Patients ◽  
Antigen Presenting
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