The impact of gender on long-term outcomes following supratentorial brain tumor resection

Abstract BACKGROUND Decline in neurocognitive functioning (NCF) often occurs following brain tumor resection. Functional connectomics have shown how neurologic insults disrupt cerebral networks underlying NCF, though studies involving patients with brain tumors are lacking. OBJECTIVE To investigate the impact of brain tumor resection upon the connectome and relationships with NCF outcome in the early postoperative period. METHODS A total of 15 right-handed adults with left perisylvian glioma underwent resting-state functional magnetic resonance imaging (rs-fMRI) and neuropsychological assessment before and after awake tumor resection. Graph theoretical analysis was applied to rs-fMRI connectivity matrices to calculate network properties. Network properties and NCF measures were compared across the pre- to postoperative periods with matched pairs Wilcoxon signed-rank tests. Associations between pre- to postoperative change in network and NCF measures were determined with Spearman rank-order correlations (ρ). RESULTS A majority of the sample showed postoperative decline on 1 or more NCF measures. Significant postoperative NCF decline was found across measures of verbal memory, processing speed, executive functioning, receptive language, and a composite index. Regarding connectomic properties, betweenness centrality and assortativity were significantly smaller postoperatively, and reductions in these measures were associated with better NCF outcomes. Significant inverse associations (ρ = −.51 to −.78, all P < .05) were observed between change in language, executive functioning, and learning and memory, and alterations in segregation, centrality, and resilience network properties. CONCLUSION Decline in NCF was common shortly following resection of glioma involving eloquent brain regions, most frequently in verbal learning/memory and executive functioning. Better postoperative outcomes accompanied reductions in centrality and resilience connectomic measures.

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Examining the Impact of the Disabled Youth Peer Development Initiative: What are the Long-Term Outcomes?

PsycEXTRA Dataset ◽

10.1037/e416902005-781 ◽

2003 ◽

Author(s):

Teresa Garate-Serafini ◽

Jose Mendez ◽

Patty Arriaga ◽

Larry Labiak ◽

Carol Reynolds

Keyword(s):

Long Term Outcomes ◽

The Disabled ◽

The Impact

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Restored Activation of Primary Motor Area from Motor Reorganization and Improved Motor Function after Brain Tumor Resection

Yearbook of Neurology and Neurosurgery ◽

10.1016/s0513-5117(08)79152-x ◽

2008 ◽

Vol 2008 ◽

pp. 204-205

Author(s):

S.R. Shepard

Keyword(s):

Brain Tumor ◽

Motor Function ◽

Tumor Resection ◽

Motor Area ◽

Primary Motor Area ◽

Motor Reorganization ◽

Brain Tumor Resection

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Impact of established cardiovascular disease on 10-year death after coronary revascularization for complex coronary artery disease

Clinical Research in Cardiology ◽

10.1007/s00392-021-01922-y ◽

2021 ◽

Author(s):

Rutao Wang ◽

Scot Garg ◽

Chao Gao ◽

Hideyuki Kawashima ◽

Masafumi Ono ◽

...

Keyword(s):

Cardiovascular Disease ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Coronary Revascularization ◽

Long Term Outcomes ◽

Vital Status ◽

Increased Risk ◽

Artery Disease ◽

The Impact

Abstract Aims To investigate the impact of established cardiovascular disease (CVD) on 10-year all-cause death following coronary revascularization in patients with complex coronary artery disease (CAD). Methods The SYNTAXES study assessed vital status out to 10 years of patients with complex CAD enrolled in the SYNTAX trial. The relative efficacy of PCI versus CABG in terms of 10-year all-cause death was assessed according to co-existing CVD. Results Established CVD status was recorded in 1771 (98.3%) patients, of whom 827 (46.7%) had established CVD. Compared to those without CVD, patients with CVD had a significantly higher risk of 10-year all-cause death (31.4% vs. 21.7%; adjusted HR: 1.40; 95% CI 1.08–1.80, p = 0.010). In patients with CVD, PCI had a non-significant numerically higher risk of 10-year all-cause death compared with CABG (35.9% vs. 27.2%; adjusted HR: 1.14; 95% CI 0.83–1.58, p = 0.412). The relative treatment effects of PCI versus CABG on 10-year all-cause death in patients with complex CAD were similar irrespective of the presence of CVD (p-interaction = 0.986). Only those patients with CVD in ≥ 2 territories had a higher risk of 10-year all-cause death (adjusted HR: 2.99, 95% CI 2.11–4.23, p < 0.001) compared to those without CVD. Conclusions The presence of CVD involving more than one territory was associated with a significantly increased risk of 10-year all-cause death, which was non-significantly higher in complex CAD patients treated with PCI compared with CABG. Acceptable long-term outcomes were observed, suggesting that patients with established CVD should not be precluded from undergoing invasive angiography or revascularization. Trial registration SYNTAX: ClinicalTrials.gov reference: NCT00114972. SYNTAX Extended Survival: ClinicalTrials.gov reference: NCT03417050. Graphic abstract

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The impact of neurosurgical technique on the short- and long-term outcomes of adult patients with Chiari I malformation

Clinical Neurology and Neurosurgery ◽

10.1016/j.clineuro.2020.106380 ◽

2021 ◽

Vol 200 ◽

pp. 106380

Author(s):

Pasquale Gallo ◽

Phillip Correia Copley ◽

Shannon McAllister ◽

Chandrasekaran Kaliaperumal

Keyword(s):

Chiari I Malformation ◽

Adult Patients ◽

Long Term Outcomes ◽

Chiari I ◽

Short And Long Term ◽

Neurosurgical Technique ◽

The Impact

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Neuroimaging at Term Equivalent Age: Is There Value for the Preterm Infant? A Narrative Summary

Children ◽

10.3390/children8030227 ◽

2021 ◽

Vol 8 (3) ◽

pp. 227

Author(s):

Rudaina Banihani ◽

Judy Seesahai ◽

Elizabeth Asztalos ◽

Paige Terrien Church

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Preterm Infant ◽

Resonance Imaging ◽

Long Term Outcomes ◽

Equivalent Age ◽

Current State ◽

Patterns Of Injury ◽

The Impact

Advances in neuroimaging of the preterm infant have enhanced the ability to detect brain injury. This added information has been a blessing and a curse. Neuroimaging, particularly with magnetic resonance imaging, has provided greater insight into the patterns of injury and specific vulnerabilities. It has also provided a better understanding of the microscopic and functional impacts of subtle and significant injuries. While the ability to detect injury is important and irresistible, the evidence for how these injuries link to specific long-term outcomes is less clear. In addition, the impact on parents can be profound. This narrative summary will review the history and current state of brain imaging, focusing on magnetic resonance imaging in the preterm population and the current state of the evidence for how these patterns relate to long-term outcomes.

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Personality and behavioral changes after brain tumor resection: a lesion mapping study

Acta Neurochirurgica ◽

10.1007/s00701-021-04756-9 ◽

2021 ◽

Vol 163 (5) ◽

pp. 1257-1267 ◽

Cited By ~ 1

Author(s):

Anne-Laure Lemaitre ◽

Guillaume Herbet ◽

Hugues Duffau ◽

Gilles Lafargue

Keyword(s):

Brain Tumor ◽

Tumor Resection ◽

Behavioral Changes ◽

Mapping Study ◽

Lesion Mapping ◽

Brain Tumor Resection

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Transanal total mesorectal excision: short- and long-term results of the first hundred cases of a certified colorectal cancer center in Germany

Surgical Endoscopy ◽

10.1007/s00464-021-08384-3 ◽

2021 ◽

Author(s):

Vinzenz Völkel ◽

Sabine Schatz ◽

Teresa Draeger ◽

Michael Gerken ◽

Monika Klinkhammer-Schalke ◽

...

Keyword(s):

Local Recurrence ◽

Tumor Resection ◽

Operation Time ◽

Cancer Center ◽

Transanal Total Mesorectal Excision ◽

Local Tumor ◽

Long Term Outcomes ◽

Free Survival ◽

Short And Long Term

Abstract Background Since 2010, laparoscopic transanal total mesorectal excision (TaTME) has been increasingly used for low and very low rectal cancer. It is supposed to improve visibility and access to the dissection planes in the pelvis. This study reports on short- and long-term outcomes of the first 100 consecutive patients treated with TaTME in a certified German colorectal cancer center. Patients and methods Data were derived from digital patient files and official cancer registry reports for patients with TaTME tumor surgery between July 2014 and January 2020. The primary outcome was the 3-year local recurrence rate and local recurrence-free survival (LRFS). Secondary endpoints included overall survival (OAS), disease-free survival (DFS), operation time, completeness of local tumor resection, lymph node resection, and postoperative complications. The Kaplan–Meier method was employed for the survival analyses; competing risks were considered in the time-to-event analysis. Results During the observation period, the average annual operation time decreased from 272 to 178 min. Complete local tumor resection was achieved in 97% of the procedures. Major postoperative complications (Clavien–Dindo 3–4) occurred in 11% of the cases. At a median follow-up time of 2.7 years, three patients had suffered from a local recurrence. Considering competing risks, this corresponds to a 3-year cumulative incidence rate for local recurrence of 2.2% and a 3-year LRFS of 81.9%. 3-year OAS was 82.9%, and 3-year DFS was 75.7%. Conclusion TaTME is associated with favorable short and long-term outcomes. Since it is technically demanding, structured training programs and more research on the topic are indispensable.

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