Which is the best method to trace group A streptococci in sore throat patients: culture or GAS antigen test?

2004 ◽  
Vol 22 (4) ◽  
pp. 233-238 ◽  
Author(s):  
Morten Lindbæk ◽  
Ernst Arne Høiby ◽  
Gro Lermark ◽  
Inger Marie Steinsholt ◽  
Per Hjortdahl
Keyword(s):  
Sore Throat ◽  
Group A Streptococci ◽  
Antigen Test ◽  
Group A

scholarly journals Streptococcal pharyngitis in general practice. 1. Some unusual features of the epidemiology

1992 ◽  
Vol 109 (2) ◽  
pp. 181-189 ◽  
Author(s):  
P. M. Higgins
Keyword(s):  
Sore Throat ◽  
Age Distribution ◽  
Positive Culture ◽  
Streptococcal Pharyngitis ◽  
Group A Streptococci ◽  
Upper Respiratory Tract ◽  
Acute Infections ◽  
Group A ◽  
Upper Respiratory ◽  
Highly Correlated

SUMMARYThis report is based on a study of acute infections of the upper respiratory tract in 1965 and detailed records of such infections in 1963 and 1964. A change from illnesses mainly yielding viruses to illnesses mainly yielding group A streptococci was noted around the age of 5 years. A positive culture for group A streptococci in patients over 4 years of age was highly correlated with a complaint of sore throat and with serological evidence of streptococcal infection. A bimodal age distribution curve for pharyngitis associated with a positive culture for group A streptococci was consistently noted. The incidence was highest in children aged 5–9 but a second smaller peak occurred among adults in the 30–39 age group. The evidence suggests that being female increases the risk of acquiring group A streptococci and of experiencing sore throat.

scholarly journals Antibody to streptococcal opacity factor in human sera

1973 ◽  
Vol 71 (1) ◽  
pp. 35-42 ◽  
Author(s):  
W. R. Maxted ◽  
Jean P. Widdowson ◽  
Cherry A. M. Fraser
Keyword(s):  
Sore Throat ◽  
Group A Streptococci ◽  
Close Correspondence ◽  
Human Sera ◽  
Group A

SUMMARYTwo tests are described for detecting antibody to the type-specific opacity factor (OF) of group A streptococci. This antibody was detected among patients convalescent from streptococcal sore throat in two communities in which out-breaks due to opacity factor-producing strains of group A streptococci occurred.In an outbreak due to streptococci of M-type 22 there was a close correspondence between the distribution of anti-OF and of bactericidal M-antibody for the type. In a smaller outbreak due to M-type 58 streptococci, however, M-antibody was detected more often than antibody of OF.

scholarly journals The production of pyrogenic exotoxins by group A streptococci

1985 ◽  
Vol 95 (1) ◽  
pp. 47-57 ◽  
Author(s):  
Gillian Hallas
Keyword(s):  
Sore Throat ◽  
Isoelectric Focusing ◽  
Scarlet Fever ◽  
Group A Streptococci ◽  
Polyacrylamide Gels ◽  
Agar Gels ◽  
Group A ◽  
Sporadic Cases ◽  
Spe B ◽  
Lancefield Group

SUMMARYLancefield group A streptococci isolated from recent outbreaks and sporadic cases of scarlet fever were restricted to the following M types 1, 3, 4, 6, 12, 18, 22 and 66. These strains were examined for the presence of streptococcal pyrogenic exotoxins (SPE) types A, B and C by isoelectric focusing in polyacrylamide gels and by immunoprecipitation in agar gels. SPE B was produced by 70% of the strains and SPEC by 40%. SPE A could not be detected in these strains. In contrast, SPE type A was found in 4 of 10 strains, held by the NCTC, that had been isolated before 1940 from patients with scarlet fever. Nine of 12 recent isolates from patients with sore throat uncomplicated by a rash produced SPE C and 4 of these also produced SPE B.

GROUP A STREPTOCOCCAL INFECTIONS IN A CHILDREN'S HOME

PEDIATRICS ◽  
1964 ◽  
Vol 33 (1) ◽  
pp. 11-17
Author(s):  
Hugh L. Moffet ◽  
Henry G. Cramblett ◽  
Annie Smith
Keyword(s):  
Sore Throat ◽  
Skin Diseases ◽  
Positive Culture ◽  
School Age ◽  
Group A Streptococci ◽  
Streptococcal Infections ◽  
Oral Temperature ◽  
Children's Home ◽  
Group A ◽  
Group B

All children admitted to a children's home infirmary for illnesses other than skin diseases or trauma during a period of 2 years were cultured for Group A streptococci and viruses. Almost 90% of the children with fever and unequivocal exudative pharyngitis had throat cultures containing more than 10 colonies of Group A streptococci. About 90% of the illnesses with sore throat or minimal erythema without fever or exudate were not associated with a similarly positive culture. About 50% of the children with only two of the three features of fever, pharyngeal exudate, and erythema had positive cultures, and it was this group of patients for whom throat cultures were most useful. Although Group B Coxsackie viruses and adenoviruses were recovered from some of the children, Group A streptococci were clearly the most frequent cause of moderate or severe pharyngitis in children of school age and were recovered from 50% of all children with an oral temperature of 38.3°C (101°F) or higher.

Acute Poststreptococcal Polymyalgia With Trismus

PEDIATRICS ◽  
1987 ◽  
Vol 80 (6) ◽  
pp. 953-954
Author(s):  
DAVID A. GREMSE ◽  
JUAN N. WALTERSPIEL
Keyword(s):  
Back Pain ◽  
Sore Throat ◽  
Skeletal Muscles ◽  
Case Reports ◽  
Plasma Concentrations ◽  
Group A Streptococci ◽  
Elevated Plasma ◽  
Muscle Enzymes ◽  
Group A ◽  
Black Boy

Acute poststreptococcal polymyalgia is an infrequently described entity that may follow infection with group A streptococci.1 Hallmarks of this condition are diffuse pain and exquisite tenderness of skeletal muscles without concomitant arthritis or elevated plasma concentrations of muscle enzymes. We recently cared for two children in whom acute poststreptococcal polymyalgia was associated with trismus. It is important to recognize this condition and distinguish it from tetanus. CASE REPORTS Case 1 A 6-year-old black boy was previously healthy until five days prior to admission when fever, sore throat, back pain, and malaise developed. On the day of admission, generalized rigidity and difficulty swallowing occurred.

scholarly journals Improving antibiotics targeting using PCR point-of-care testing for group A streptococci in patients with uncomplicated acute sore throat

2021 ◽  
Vol 50 (1-2) ◽  
pp. 76-83
Author(s):  
Ronny K Gunnarsson ◽  
Ulrich Orda ◽  
Bradley Elliott ◽  
Clare Heal ◽  
Hilary Gorges ◽  
...  
Keyword(s):  
Sore Throat ◽  
Point Of Care ◽  
Group A Streptococci ◽  
Point Of Care Testing ◽  
Group A

scholarly journals Is It a Necessity to Use Double Swab in the Detection of Group A Streptococci by the Strep A Rapid Antigen Test?

2019 ◽  
Author(s):  
Mehmet Emin Bulut ◽  
Elif Aktaş ◽  
Gülşah Malkoçoğlu ◽  
Vildan Yavuz Özer ◽  
Berna Ünal ◽  
...  
Keyword(s):  
Group A Streptococci ◽  
Antigen Test ◽  
Group A

scholarly journals Presence of microorganisms in children with pharyngotonsillitis and healthy controls: a prospective study in primary healthcare

Infection ◽  
2021 ◽  
Author(s):  
Jon Pallon ◽  
Martin Sundqvist ◽  
Mattias Rööst ◽  
Patrik Danielsson ◽  
Thomas Neumark ◽  
...  
Keyword(s):  
Prospective Study ◽  
Sore Throat ◽  
Primary Healthcare ◽  
Clinical Symptoms ◽  
Clinical Signs ◽  
High Rate ◽  
Common Finding ◽  
Group A Streptococci ◽  
Asymptomatic Children ◽  
Group A

Abstract Purpose Most studies on paediatric pharyngotonsillitis focus on group A streptococci. This study, however, analyses a broad spectrum of bacteria and viruses related to paediatric pharyngotonsillitis and evaluates their associated clinical symptoms and courses. Methods This observational prospective study in primary healthcare includes 77 children aged < 15 with a sore throat and 34 asymptomatic children, all of whom were sampled from the tonsils with an E-swab® for analysis with culture and PCR for 14 bacteria and 15 viruses. Patients were evaluated clinically, and their symptoms recorded in diaries for 10 days. Participants were followed up for 3 months by reviewing medical records. Results A pathogen was detected in 86% of patients and in 71% of controls (P = 0.06). Bacteria were found in 69% of patients and 59% of controls (P = 0.3), and viruses in 36% and 26%, respectively (P = 0.3). Group A streptococci was the most common finding, with a prevalence of 49% and 32%, respectively (P = 0.1). Clinical signs were not useful for distinguishing pathogens. None of the controls and 16% of the patients reconsulted for a sore throat within 3 months. Conclusion Bacteria were more common than viruses in both study groups. The high rate of pathogens in asymptomatic children interferes with diagnoses based on aetiology.

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