Investigation of Hypromellose Particle Size Effects on Drug Release from Sustained Release Hydrophilic Matrix Tablets

2007 ◽  
Vol 33 (9) ◽  
pp. 952-958 ◽  
Author(s):  
Shawn A. Mitchell ◽  
Karen M. Balwinski
Keyword(s):  
Particle Size ◽  
Drug Release ◽  
Sustained Release ◽  
Size Effects ◽  
Matrix Tablets ◽  
Hydrophilic Matrix ◽  
Particle Size Effects

scholarly journals Formulation of Sustained Release Hydrophilic Matrix Tablets of Tolcapone with the Application of Sedem Diagram: Influence of Tolcapone’s Particle Size on Sustained Release

Pharmaceutics ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 674 ◽  
Author(s):  
Anna Nardi-Ricart ◽  
Isaac Nofrerias-Roig ◽  
Marc Suñé-Pou ◽  
Pilar Pérez-Lozano ◽  
Montse Miñarro-Carmona ◽  
...  
Keyword(s):  
Particle Size ◽  
Sustained Release ◽  
Potent Inhibitor ◽  
High Viscosity ◽  
Matrix Tablets ◽  
Formulation Development ◽  
Methyl Transferase ◽  
Diagram Method ◽  
Hydrophilic Matrix ◽  
Amyloid Polyneuropathy

Hydrophilic matrix tablets are a type of sustained release dosage form characterized by distributing a drug in a matrix that is usually polymeric. Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase. In recent years, it has been shown that tolcapone is a potent inhibitor of the amyloid aggregation process of the transthyretin protein, and acts by stabilizing the structure of the protein, reducing the progression of familial amyloid polyneuropathy. The main objective of this study was to obtain a sustained release tablet of tolcapone for oral administration with a preferred dosage regimen of 1 administration every 12 or 24 h and manufactured, preferably, by direct compression. The SeDeM Diagram method has been used for the formulation development of hydrophilic matrix tablets. Given the characteristics of tolcapone, the excipient selected for the formation of the polymeric matrix was a high viscosity hydroxypropylmethylcellulose (Methocel® K100M CR). A decrease in the particle size of tolcapone resulted in a slower dissolution release of the formulation when the concentration of the polymer Methocel® K100M CR was below 29%. These surprising and novel results have given rise to patent number WO/2018/019997.

Effects of release modifier on Carvedilol release from Kollidon SR based matrix

2012 ◽  
Vol 1 (8) ◽  
pp. 186 ◽  
Author(s):  
Urmi Das ◽  
Mohammad Salim Hossain
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Microcrystalline Cellulose ◽  
Matrix Tablets ◽  
Dissolution Time ◽  
Release Mechanism ◽  
Matrix Tablet ◽  
Weight Variation ◽  
The Matrix ◽  
Tablet Formulations

<p>Sustained release Carvedilol matrix tablets constituting Kollidon SR were developed in this study in an attempt to investigate the effect of release modifiers on the release profile of Carvedilol from matrix. Three matrix tablet formulations were prepared by direct compression of Kollidon SR in combination with release modifier (HPMC and Microcrystalline Cellulose) and magnesium stearate. Tablets containing only Kollidon SR with the active ingredient demonstrated a rapid rate of drug release. Incorporation of HPMC in the matrix tablet prolonged the release of drug but incorporation of Microcrystalline Cellulose showed superimposable release pattern with an initial burst effect as confirmed by mean dissolution time and Higuchi release rate data. After 7 hours of dissolution, Carvedilol release from the matrix systems were 91.42%, 83.41%, from formulation F1 and F2 respectively. Formulation F3 exhibited 100 % release at 4 hours. All the tablet formulations showed acceptable pharmaco-technical properties and complied with the in-house specifications for tablet weight variation, friability, hardness, thickness, and diameter. Prepared tablets also showed sustained release property for carvedilol. The drug release mechanism from the matrix tablets of F1 and F2 was found to be followed by Fickian and F3 by Non-Fickian mechanism.</p><p>DOI: <a href="http://dx.doi.org/10.3329/icpj.v1i8.11095">http://dx.doi.org/10.3329/icpj.v1i8.11095</a></p> <p>International Current Pharmaceutical Journal 2012, 1(8): 186-192</p>

Adsorption mechanism of two pesticides on polyethylene and polypropylene microplastics: DFT calculations and particle size effects

2021 ◽  
Vol 291 ◽  
pp. 118120
Author(s):  
Qiming Mo ◽  
Xingjian Yang ◽  
Jinjin Wang ◽  
Huijuan Xu ◽  
Wenyan Li ◽  
...  
Keyword(s):  
Particle Size ◽  
Dft Calculations ◽  
Size Effects ◽  
Adsorption Mechanism ◽  
Particle Size Effects

Particle size effects in the selective hydrogenation of cinnamaldehyde over supported palladium catalysts

RSC Advances ◽  
2016 ◽  
Vol 6 (79) ◽  
pp. 75541-75551 ◽  
Author(s):  
Feng Jiang ◽  
Jian Cai ◽  
Bing Liu ◽  
Yuebing Xu ◽  
Xiaohao Liu
Keyword(s):  
Particle Size ◽  
Size Effect ◽  
Selective Hydrogenation ◽  
Size Effects ◽  
Palladium Catalysts ◽  
Particle Size Effect ◽  
Particle Size Effects ◽  
Supported Palladium Catalysts ◽  
Supported Palladium ◽  
Palladium Particles

Palladium particles of different sizes obtained directly and indirectly by various methods were studied to clarify the particle size effect in the selective hydrogenation of cinnamaldehyde (CAL).

scholarly journals In vitro Release Kinetics Study of Ranolazine from Swellable Hydrophilic Matrix Tablets

1970 ◽  
Vol 8 (1) ◽  
pp. 31-38 ◽  
Author(s):  
Mohammad Nezab Uddin ◽  
Ishtiaq Ahmed ◽  
Monzurul Amin Roni ◽  
Muhammad Rashedul Islam ◽  
Mohammad Habibur Rahman ◽  
...  
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Release Kinetics ◽  
In Vitro Release ◽  
High Viscosity ◽  
Matrix Tablets ◽  
Release Studies ◽  
The Matrix ◽  
Vitro Release

The objective of this study was to design oral sustained release matrix tablets of Ranolazine usinghydroxypropyl methylcellulose (HPMC) as the retardant polymer and to study the effect of formulation factors suchas polymer proportion and polymer viscosity on the release of drug. In vitro release studies were performed usingUSP type II apparatus (paddle method) in 900 mL of 0.1N HCl at 100 rpm for 12 hours. The release kinetics wasanalyzed using the zero-order, first order, Higuchi and Korsmeyer-Peppas equations to explore and explain themechanism of drug release from the matrix tablets. In vitro release studies revealed that the release rate decreasedwith increase in polymer proportion and viscosity grade. Mathematical analysis of the release kinetics indicated thatthe nature of drug release from the matrix tablets was dependent on drug diffusion and polymer relaxation andtherefore followed non-Fickian or anomalous release. The developed controlled release matrix tablets of Ranolazineprepared with high viscosity HPMC extended release up to 12 hours.Key words: Ranolazine; Sustained release; Methocel E50 Premium LV; Methocel K100LV CR; Methocel K4M CR;Methocel K15M CR.DOI: 10.3329/dujps.v8i1.5333Dhaka Univ. J. Pharm. Sci. 8(1): 31-38, 2009 (June)

Particle size effects on stripe ordering and magnetic properties in nanosized La5/3Sr1/3NiO4

2008 ◽  
Vol 147 (7-8) ◽  
pp. 258-261 ◽  
Author(s):  
Jiyin Zhao ◽  
Lei Shi ◽  
Shiming Zhou ◽  
Laifa He ◽  
Lin Chen
Keyword(s):  
Particle Size ◽  
Magnetic Properties ◽  
Size Effects ◽  
Particle Size Effects
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