Application of design of experiments for formulation development and mechanistic evaluation of iontophoretic tacrine hydrochloride delivery

2016 ◽  
Vol 42 (11) ◽  
pp. 1894-1902 ◽  
Author(s):  
Niketkumar Patel ◽  
Shashank Jain ◽  
Parshotam Madan ◽  
Senshang Lin
Keyword(s):  
Design Of Experiments ◽  
Formulation Development ◽  
Tacrine Hydrochloride

scholarly journals A Review on Computer - Aided Formulation Development

2019 ◽  
pp. 328-337
Author(s):  
Chaudhari R. G. ◽  
Raut D. B. ◽  
Barhewar P. A. ◽  
Mali A. S. ◽  
Burade K. B.
Keyword(s):  
Neural Networks ◽  
Design Of Experiments ◽  
Quality By Design ◽  
Processing Parameters ◽  
Computer Applications ◽  
Design Development ◽  
Formulation Development ◽  
Critical Quality Attributes ◽  
Double Emulsions ◽  
Computer Aided

This chapter introduces the concept of formulation development assisted by computer applications. Development and optimization of various types of pharmaceutical emulsions microemulsions, self- microemulsifying systems, and double emulsions are presented. Illustrative examples are presented to demonstrate the ability of computer-aided tools to facilitate formulation development. Various techniques, such as design of experiments and arti?cial neural networks, are implemented for optimization of the formulation and/or processing parameters. Furthermore, some of the critical quality attributes and processing parameters are optimized simultaneously. The examples presented should serve as the foundation for the future quality- by-design development of pharmaceutical emulsion and (self) microemulsion formulations.

scholarly journals Application of Sequential Design of Experiments to Develop Ibuprofen (400 mg) Tablets by Direct Compression

2017 ◽  
Vol 2 (1) ◽  
pp. 10
Author(s):  
Socorro Alpizar-Ramos ◽  
Mario González-de la Parra
Keyword(s):  
Design Of Experiments ◽  
Tablet Formulation ◽  
Sequential Design ◽  
Drug Substance ◽  
Direct Compression ◽  
Formulation Development ◽  
Efficient Strategy ◽  
The Poor

A strategy based on sequential design of experiments (screening, optimization and confirmation) was used to develop a tablet formulation of ibuprofen (400 mg) that is manufactured by direct compression. This formulation has a high content of ibuprofen (76%), in spite of the poor flowability of the drug substance. Sequential design of experiments proved to be an effective and efficient strategy in formulation development.

Projektowanie dla jakości metodami Shainina i Taguchiego

2008 ◽  
pp. 36-38
Author(s):  
Jarosław Sęp ◽  
Andrzej Pacana
Keyword(s):  
Design Of Experiments

Zespół metod wykorzystywanych do planowania eksperymentów określa się jako Design of Experiments -DOE. Celem stosowania DOE jest uzyskanie jak największej ilości wartościowych i wiarygodnych informacji o badanym wyrobie lub procesie na podstawie jak najmniejszej liczby doświadczeń. W artykule zwrócono uwagę na stosunkowo mało znane metody opracowane przez Shainina oraz Taguchiego. Przedstawiono dobór parametrów metodą Shainina i Taguchiego na przykładzie procesu toczenia.

Defect Reduction in Ring Blank Casting Through Design of Experiments

2015 ◽  
Vol 9 (6) ◽  
pp. 536 ◽  
Author(s):  
P. Kannan ◽  
K. Balasubramanian ◽  
R. Vinayagamoorthy
Keyword(s):  
Design Of Experiments ◽  
Defect Reduction ◽  
Ring Blank
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