A Partial Test of Moffitt’s Developmental Taxonomy: Examining the Role of Genetic Risk

There is little question that precision medicine will eventually be the standard of care in treatment with algorithms designed for therapy selection and is already being used in some specialties such as cystic fibrosis and multiple cancer treatments. Genetic counselors are the heart of the treatment team in relation to counseling regarding genetic risk factors and disease states. A framework for treatment within the interdisciplinary team with more defined roles and areas of specialty will need to be in place as this practice approach expands with new data and treatments. Pharmacists are poised to be of great assistance in this matrix as many of these roles are merely an extension of current tasks and responsibilities of pharmacy practice.

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Validating the role of the Australian National University Alzheimer’s Disease Risk Index (ANU-ADRI) and a genetic risk score in progression to cognitive impairment in a population-based cohort of older adults followed for 12 years

Alzheimer s Research & Therapy ◽

10.1186/s13195-017-0240-3 ◽

2017 ◽

Vol 9 (1) ◽

Cited By ~ 14

Author(s):

Shea J. Andrews ◽

Ranmalee Eramudugolla ◽

Jorge I. Velez ◽

Nicolas Cherbuin ◽

Simon Easteal ◽

...

Keyword(s):

Older Adults ◽

Cognitive Impairment ◽

Risk Score ◽

Genetic Risk ◽

Disease Risk ◽

Genetic Risk Score ◽

Risk Index ◽

Population Based ◽

National University

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Association of Genetic Polymorphisms in GSTP1, GSTM1, and GSTT1 Genes with Vesicoureteral Reflux Susceptibility in the Children of Southeast Iran

Iranian Journal of Public Health ◽

10.18502/ijph.v49i7.3591 ◽

2020 ◽

Author(s):

Sima SHAHROKHZADEH ◽

Azam SOLEIMANI ◽

Dor-Mohammad KORDI-TAMANDANI ◽

Mohammad Hossein SANGTARASH ◽

Omid NEJATI ◽

...

Keyword(s):

Vesicoureteral Reflux ◽

Genetic Risk ◽

Protective Role ◽

Common Type ◽

Chain Reaction ◽

Eastern Iran ◽

Multifunctional Enzymes ◽

Glutathione S Transferases ◽

Polymerase Chain

Background: Vesicoureteral reflux (VUR) disease is the most common type of urinary tract anomalies in children. Genetic risk factors may be associated with the etiology of VUR. The role of the Glutathione S-transferases (GSTs) as multifunctional enzymes is cellular oxidative stress handling. This is the first study aimed at evaluating the relative risk of GSTP1, GSTM1, and GSTT1 polymorphisms in VUR susceptibility in children and provides new important insights into the genetics of affected children. Methods: The study was done in 2013 in Sistan and Baluchestan University, eastern Iran. Genotyping of three GSTP1, GSTM1, and GSTT1 genes were determined using the multiplex polymerase chain reaction assay in 216 reactions for 72 VUR children and 312 reactions for 104 healthy controls. Results: The presence of GSTT1 deletion was associated with high risk of VUR in children, whereas GSTP1 and GSTM1 genotypes did not show the same effect. Furthermore, the combination of GSTT1/GSTM1 and GSTT1/ GSTP1 genotypes showed a significant influence on lower risk of VUR in children. Conclusion: Deletion of GSTT1 functional gene is a genetic risk factor causing VUR in children. Interestingly, the combination of GSTM1 and GSTP1 null genotypes with GSTT1 has shown a protective role against risk of GSTT1 deletion.

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Childhood Porencephaly: Role of Genetic Risk Factors in Familial Trombophilia

28. Hämophilie-Symposion Hamburg 1997 ◽

10.1007/978-3-642-59915-6_48 ◽

1999 ◽

pp. 310-317

Author(s):

H. Vielhaber ◽

O. Debus ◽

G. Kurlemann ◽

R. Sträter ◽

U. Nowak-Göttl

Keyword(s):

Risk Factors ◽

Genetic Risk ◽

Genetic Risk Factors

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Late-onset schizophrenia

Oxford Textbook of Old Age Psychiatry ◽

10.1093/med/9780198807292.003.0043 ◽

2020 ◽

pp. 671-694

Author(s):

Ellen E. Lee ◽

Baichun Hou ◽

Ipsit V. Vahia ◽

Dilip V. Jeste

Keyword(s):

Risk Factors ◽

Differential Diagnosis ◽

Life Events ◽

Genetic Risk ◽

Psychiatric Symptoms ◽

Late Onset ◽

Sociodemographic Factors ◽

Sensory Loss ◽

Adverse Life Events

Late-onset schizophrenia remains an understudied subtype of schizophrenia, despite growing recognition of its impact and distinction from early-onset schizophrenia. This chapter reviews the existing literature on late-onset schizophrenia including beginning with the nomenclature and epidemiology. Then we provide a review of key risk factors and correlates—including genetic risk, sex differences, comorbid sensory loss and physical illness, cognitive and psychiatric symptoms, sociodemographic factors, adverse life events, neuropathology, and inflammation. The chapter ends with clinical issues, including symptoms, differential diagnosis, treatments, and prognosis. Recent studies have examined the role of oestrogen treatments and a new therapy for tardive dyskinesia therapy as well as inflammatory mechanisms in schizophrenia.

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