Effects of galectin-1 on immunomodulatory properties of human monocyte-derived dendritic cells

2021 ◽  
pp. 1-12
Author(s):  
Tanja Džopalić ◽  
Miloš Kostić ◽  
Milena Kostić ◽  
Goran Marjanović ◽  
Jelena Guzina ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Human Monocyte ◽  
Immunomodulatory Properties

scholarly journals Human Herpesvirus 6A Induces Dendritic Cell Death and HMGB1 Release without Virus Replication

Pathogens ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 57
Author(s):  
Rasmus Gustafsson
Keyword(s):  
Cell Death ◽  
Dendritic Cells ◽  
High Mobility ◽  
Human Herpesvirus ◽  
Human Monocyte ◽  
Hmgb1 Protein ◽  
Innate And Adaptive Immunity ◽  
Th2 Polarization ◽  
Dependent Cell ◽  
Ifn Γ

Human herpesvirus 6A (HHV-6A) is a common virus that has important immunomodulatory effects. Dendritic cells (DC) are key players in innate and adaptive immunity and are implicated in the pathogenesis of many human diseases, including infections. (1) Background: Previous studies have demonstrated suppressive effects of HHV-6A on key DC functions. (2) Methods: human monocyte derived dendritic cells were inoculated with HHV-6A and viral replication, cell viability, and release of high mobility group box 1 (HMGB1) protein from DC and of the cytokines IL-2, IL-4, IL-6, IL-10, TNF and IFN-γ after co-culture with allogenic CD4+ T cells were assessed. (3) Results: Nonproductive infection of HHV-6A in DC leads to titer-dependent cell death and the release of HMGB1 protein, and a Th2 polarization. (4) Conclusion: These immune responses aimed to clear the infection may also imply risks for inflammatory pathologies associated with HHV-6A such as multiple sclerosis.

scholarly journals IFN-γ and R-848 Dependent Activation of Human Monocyte-Derived Dendritic Cells by Neisseria meningitidis Adhesin A

2007 ◽  
Vol 179 (6) ◽  
pp. 3904-3916 ◽  
Author(s):  
Cristina Mazzon ◽  
Barbara Baldani-Guerra ◽  
Paola Cecchini ◽  
Tihana Kasic ◽  
Antonella Viola ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Neisseria Meningitidis ◽  
Human Monocyte ◽  
Ifn Γ

3,10-Dihydroxy-decanoic acid, isolated from royal jelly, stimulates Th1 polarising capability of human monocyte-derived dendritic cells

2011 ◽  
Vol 126 (3) ◽  
pp. 1211-1217 ◽  
Author(s):  
Tanja Dzopalic ◽  
Dragana Vucevic ◽  
Sergej Tomic ◽  
Jelena Djokic ◽  
Ioanna Chinou ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Royal Jelly ◽  
Human Monocyte ◽  
Decanoic Acid

scholarly journals Costimulation of Dectin-1 and DC-SIGN Triggers the Arachidonic Acid Cascade in Human Monocyte-Derived Dendritic Cells

2008 ◽  
Vol 180 (8) ◽  
pp. 5727-5736 ◽  
Author(s):  
Isela Valera ◽  
Nieves Fernández ◽  
Antonio García Trinidad ◽  
Sara Alonso ◽  
Gordon D. Brown ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Arachidonic Acid ◽  
Human Monocyte ◽  
Arachidonic Acid Cascade

scholarly journals siRNA-based identification of IBD-related targets in human monocyte-derived dendritic cells

2021 ◽  
pp. 113058
Author(s):  
Diane Bosman-Schluep ◽  
Remko de Pril ◽  
Banu Verbaken ◽  
Anaïs Legent ◽  
Jan Stallen ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Human Monocyte

scholarly journals Effects of Staphylococcus aureus Bacteriophage K on Expression of Cytokines and Activation Markers by Human Dendritic Cells In Vitro

Viruses ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 617 ◽  
Author(s):  
Helen Freyberger ◽  
Yunxiu He ◽  
Amanda Roth ◽  
Mikeljon Nikolich ◽  
Andrey Filippov
Keyword(s):  
Staphylococcus Aureus ◽  
Dendritic Cells ◽  
Inflammatory Response ◽  
Adaptive Immune Response ◽  
Human Monocyte ◽  
Activation Markers ◽  
Mhc I ◽  
Adaptive Immune ◽  
Human Dendritic Cells

A potential concern with bacteriophage (phage) therapeutics is a host-versus-phage response in which the immune system may neutralize or destroy phage particles and thus impair therapeutic efficacy, or a strong inflammatory response to repeated phage exposure might endanger the patient. Current literature is discrepant with regard to the nature and magnitude of innate and adaptive immune response to phages. The purpose of this work was to study the potential effects of Staphylococcus aureus phage K on the activation of human monocyte-derived dendritic cells. Since phage K acquired from ATCC was isolated around 90 years ago, we first tested its activity against a panel of 36 diverse S. aureus clinical isolates from military patients and found that it was lytic against 30/36 (83%) of strains. Human monocyte-derived dendritic cells were used to test for an in vitro phage-specific inflammatory response. Repeated experiments demonstrated that phage K had little impact on the expression of pro- and anti-inflammatory cytokines, or on MHC-I/II and CD80/CD86 protein expression. Given that dendritic cells are potent antigen-presenting cells and messengers between the innate and the adaptive immune systems, our results suggest that phage K does not independently affect cellular immunity or has a very limited impact on it.

Sign in / Sign up

Export Citation Format

Share Document