scholarly journals Clofibric acid induces hepatic CYP 2B1/2 via constitutive androstane receptor not via peroxisome proliferator activated receptor alpha in rat

2014 ◽  
Vol 78 (9) ◽  
pp. 1550-1559
Author(s):  
Zein Shaban Ibrahim ◽  
Mohamed Mohamed Ahmed ◽  
Samir Ahmed El-Shazly ◽  
Mayumi Ishizuka ◽  
Shoichi Fujita
Keyword(s):  
Constitutive Androstane Receptor ◽  
Clofibric Acid ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Receptor Alpha

scholarly journals Clofibric Acid, a Peroxisome Proliferator-activated Receptor Alpha Ligand, Enhances a Suppressive Effect of Cis-diaminedichloroplatinum on Proliferation of Ovarian Carcinoma Cells

2007 ◽  
Vol 1 ◽  
pp. CMO.S283
Author(s):  
Yoshihito Yokoyama ◽  
Bing Xin ◽  
Tatsuhiko Shigeto ◽  
Masayuki Futagami ◽  
Hideki Mizunuma
Keyword(s):  
Ovarian Carcinoma ◽  
Suppressive Effect ◽  
Clofibric Acid ◽  
Carcinoma Cells ◽  
Peroxisome Proliferator ◽  
Simultaneous Treatment ◽  
Peroxisome Proliferator Activated Receptor ◽  
Receptor Alpha ◽  
Ovarian Carcinoma Cells ◽  
Induced Apoptosis

The purpose of this study was to elucidate the possible mechanism that clofibric acid (CA), a peroxisome proliferator-activated receptor α ligand, enhances a suppressive effect of cis-diaminedichloroplatinum (CDDP) on proliferation of the ovarian carcinoma line OVCAR-3. These cells was incubated with 0.5 μM/ml CDDP in the presence or absence of 50 μM CA or incubated with 50 μM CA alone for 72 hr. While treatment with CA alone did not affect proliferation of OVCAR-3 cells, simultaneous treatment with CDDP and CA significantly suppressed proliferation of the cells and significantly induced apoptosis compared to that with CDDP alone. Treatment with CDDP and CA significantly decreased the prostaglandin (PG) E2 level in the medium of the cells compared with treatment with CDDP alone. These results suggest the ability of CA to enhance a suppressive effect of CDDP on proliferation of the ovarian carcinoma cells through reduction of PGE2 level.

Sign in / Sign up

Export Citation Format

Share Document