A core-shell structured alginate hydrogel beads with tunable thickness of Carboxymethyl cellulose coating for pH responsive drug delivery

2020 ◽  
pp. 1-13
Author(s):  
Mingzhu Yan ◽  
Tiantian Chen ◽  
Shuping Zhang ◽  
Ting Lu ◽  
Ximeng Sun
Keyword(s):  
Drug Delivery ◽  
Carboxymethyl Cellulose ◽  
Core Shell ◽  
Ph Responsive ◽  
Alginate Hydrogel ◽  
Hydrogel Beads

scholarly journals pH-Responsive Succinoglycan-Carboxymethyl Cellulose Hydrogels with Highly Improved Mechanical Strength for Controlled Drug Delivery Systems

Polymers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 3197
Author(s):  
Younghyun Shin ◽  
Dajung Kim ◽  
Yiluo Hu ◽  
Yohan Kim ◽  
In Ki Hong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mechanical Strength ◽  
Carboxymethyl Cellulose ◽  
Polymer Network ◽  
Controlled Drug Release ◽  
Interpenetrating Polymer Network ◽  
Ph Responsive ◽  
Hek 293 ◽  
Natural Polysaccharide ◽  
293 Cells

Carboxymethyl cellulose (CMC)-based hydrogels are generally superabsorbent and biocompatible, but their low mechanical strength limits their application. To overcome these drawbacks, we used bacterial succinoglycan (SG), a biocompatible natural polysaccharide, as a double crosslinking strategy to produce novel interpenetrating polymer network (IPN) hydrogels in a non-bead form. These new SG/CMC-based IPN hydrogels significantly increased the mechanical strength while maintaining the characteristic superabsorbent property of CMC-based hydrogels. The SG/CMC gels exhibited an 8.5-fold improvement in compressive stress and up to a 6.5-fold higher storage modulus (G′) at the same strain compared to the CMC alone gels. Furthermore, SG/CMC gels not only showed pH-controlled drug release for 5-fluorouracil but also did not show any cytotoxicity to HEK-293 cells. This suggests that SG/CMC hydrogels could be used as future biomedical biomaterials for drug delivery.

A pH-responsive amphiphilic chitosan–pyranine core–shell nanoparticle for controlled drug delivery, imaging and intracellular pH measurement

2014 ◽  
Vol 2 (38) ◽  
pp. 6580-6589 ◽  
Author(s):  
Hao-Syun Chou ◽  
Meng-Hsuan Hsiao ◽  
Wei-Yang Hung ◽  
Tin-Yo Yen ◽  
Hui-Yi Lin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Intracellular Ph ◽  
Controlled Drug Delivery ◽  
Ph Measurement ◽  
Core Shell ◽  
Ph Responsive ◽  
Cellular Resolution ◽  
New Type

A new type of CHC–PY core–shell nanoparticle provides multiple functionality, where a synergistic performance of nanotherapeutics, imaging and even diagnosis at a cellular resolution can be achieved simultaneously.

Crown ether triad modified core–shell magnetic mesoporous silica nanocarrier for pH-responsive drug delivery and magnetic hyperthermia applications

2017 ◽  
Vol 41 (19) ◽  
pp. 10935-10947 ◽  
Author(s):  
Madhappan Santha Moorthy ◽  
Subramanian Bharathiraja ◽  
Panchanathan Manivasagan ◽  
Kang Dae Lee ◽  
Junghwan Oh
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Crown Ether ◽  
Magnetic Hyperthermia ◽  
Core Shell ◽  
Ph Responsive ◽  
Magnetic Mesoporous Silica

A “host–guest” complexation-based core–shell FeNP@SiOH@CET NP system was fabricated for chemotherapy and magnetic hyperthermia applications.

scholarly journals Core–shell structured nanospheres for photothermal ablation and pH-triggered drug delivery toward synergistic cancer therapy

RSC Advances ◽  
2017 ◽  
Vol 7 (43) ◽  
pp. 26640-26649 ◽  
Author(s):  
Tian Zhong ◽  
Jia Fu ◽  
Ran Huang ◽  
Lianjiang Tan
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Core Shell ◽  
Ph Responsive ◽  
Photothermal Conversion ◽  
Photothermal Ablation

Core–shell CuS(DOX)@CS nanospheres with pH-responsive drug release ability and photothermal conversion properties are synthesized for synergistic cancer therapy.

Fe3O4@nanogel via UOx/HRP initiated surface polymerization for pH sensitive drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (58) ◽  
pp. 53170-53174 ◽  
Author(s):  
Qing Wu ◽  
Zhaoqi Wang ◽  
Haixia Zhang ◽  
Rongrong Zhu ◽  
Shilong Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Free Radical ◽  
Drug Release ◽  
Radical Polymerization ◽  
High Loading ◽  
Core Shell ◽  
Loading Capacity ◽  
Ph Responsive ◽  
Surface Polymerization ◽  
New Strategy

This study describes a new strategy to fabricate core–shell nanogels by surface free-radical polymerization initiated by the cascade reaction of UOx and HRP, which showed excellent biocompatible, high loading capacity and pH-responsive drug release.

Fabrication of novel core-shell hybrid alginate hydrogel beads

2008 ◽  
Vol 351 (1-2) ◽  
pp. 104-112 ◽  
Author(s):  
H LIU ◽  
C WANG ◽  
Q GAO ◽  
X LIU ◽  
Z TONG
Keyword(s):  
Core Shell ◽  
Alginate Hydrogel ◽  
Hydrogel Beads

scholarly journals Multifunctional chitosan modified Gd2O3:Yb3+,Er3+@nSiO2@mSiO2 core/shell nanoparticles for pH responsive drug delivery and bioimaging

RSC Advances ◽  
2017 ◽  
Vol 7 (17) ◽  
pp. 10287-10294 ◽  
Author(s):  
Shanshan Huang ◽  
Ping'an Ma ◽  
Ziyong Cheng ◽  
Bei Liu ◽  
Xiaoran Deng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Core Shell ◽  
Ph Responsive ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

Chitosan modified Gd2O3:Yb3+,Er3+@nSiO2@mSiO2 core/shell nanoparticles were synthesized for pH responsive drug delivery and bioimaging.

scholarly journals Synthesis, Characterization, and Drug Delivery from pH- and Thermoresponsive Poly(N-Isopropylacrylamide)/Chitosan Core/Shell Nanocomposites Made by Semicontinuous Heterophase Polymerization

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Abraham G. Alvarado ◽  
Andres Ortega ◽  
Lourdes A. Pérez-Carrillo ◽  
Israel Ceja ◽  
Martin Arellano ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Crosslinking Agent ◽  
Core Shell ◽  
Ph Responsive ◽  
Doxycycline Hyclate ◽  
Shell Nanoparticles ◽  
Heterophase Polymerization ◽  
Heating And Cooling ◽  
Core Shell Nanoparticles ◽  
Semicontinuous Heterophase Polymerization

Temperature- and pH-responsive core/shell nanoparticles were prepared by semicontinuous heterophase polymerization of N-isopropylacrylamide (NIPA) in the presence of chitosan micelles for drug delivery purposes. Micelles of chitosan, formed in an acetic acid aqueous solution at 70°C containing potassium persulfate, were fed with N-isopropylacrylamide (NIPA) at a controlled rate, to produce PNIPA/chitosan core/shell nanoparticles of about 350 nm. Then, the crosslinking agent, glutaraldehyde, was added to crosslink the nanoparticles. These nanocomposites were temperature- and pH-responsive, which make them suitable as controlled drug releasing agents. The nanoparticles exhibit thermoreversibility to heating-and-cooling cycles and show different responses depending on the releasing medium’s pH. Drug delivery tests were performed, employing as a model drug, doxycycline hyclate.

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