Association between soft drink consumption and handgrip strength in middle aged and older adults: the TCLSIH cohort study

PURPOSE: We investigated whether relative handgrip strength (RHS) and change in handgrip strength predicted Type 2 DM incidence in middle-aged and older adults.METHODS: Total of 29,098 participants (8,609 men and 20,489 women) aged 40-69 who were free of diabetes at the baseline examination drawn from the Korean Genome and Epidemiology Study-Urban Health Examinees cohort (KoGES-HEXA), a large prospective population-based study. RHS was assessed with a dynamometer and divided by body mass index. Diabetes was defined as selfreported physician-diagnosed diabetes, use of anti-diabetic medications or measured fasting glucose ≥126 mg/dl, or glycated hemoglobin (HbA1C) ≥6.5%. Cox proportional hazard regression analysis was used to estimate the hazard ratio (HRs) and 95% confidence intervals (CIs) of Diabetes incidences according to baseline RHS levels and RHS changes.RESULTS: During a mean follow-up period of 4 years (49.8±13.3 month), 1,167 (4.0%) participants developed diabetes. Compared with the high RHS group, higher risk of diabetes incidence was observed in low RHS group (men HR=1.28, 95% CI 1.06-1.55, women HR=1.32, 95% CI 1.12-1.54) after adjusted for age, triglyceride, cigarette smoking, alcohol consumption, marriage, income, education hypertension, family history of diabetes, fasting glucose, regular exercise. In addition, compared with the sustained high RHS group, sustained low RHS group showed an increased risk of diabetes incidence (men HR=1.60, 95% CI 1.28-2.00, women HR=1.85, 95% CI 1.52-2.24) after adjustment. However, the risk was not statistically significant in increased RHS group (men HR=0.98, 95% CI 0.73-1.31, women HR=1.11, 95% CI 0.85-1.43).CONCLUSIONS: The present findings indicate that RHS is independently associated with the risk of incident diabetes in middle and older adults. RHS measurement may be useful to identify individuals at increased risk for diabetes incidence. Maintaining a high level of RHS is important strategies for diabetes prevention among adults.

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Life’s simple 7 and all-cause mortality. A population-based prospective cohort study in middle-aged and older adults of Amerindian ancestry living in rural Ecuador

Preventive Medicine Reports ◽

10.1016/j.pmedr.2021.101668 ◽

2022 ◽

Vol 25 ◽

pp. 101668

Author(s):

Oscar H. Del Brutto ◽

Robertino M. Mera ◽

Bettsy Y. Recalde ◽

Denisse A. Rumbea ◽

Mark J. Sedler

Keyword(s):

Older Adults ◽

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Population Based ◽

Middle Aged ◽

All Cause Mortality ◽

Life’S Simple 7 ◽

Life's Simple 7

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Is older age associated with COVID-19 mortality in the absence of other risk factors? General population cohort study of 470,034 participants

PLoS ONE ◽

10.1371/journal.pone.0241824 ◽

2020 ◽

Vol 15 (11) ◽

pp. e0241824 ◽

Cited By ~ 1

Author(s):

Frederick K. Ho ◽

Fanny Petermann-Rocha ◽

Stuart R. Gray ◽

Bhautesh D. Jani ◽

S. Vittal Katikireddi ◽

...

Keyword(s):

Risk Factors ◽

Older Adults ◽

Cohort Study ◽

Mortality Risk ◽

Handgrip Strength ◽

Older Age ◽

High Systolic Blood Pressure ◽

Long Term Conditions ◽

Population Cohort ◽

Population Cohort Study

Introduction Older people have been reported to be at higher risk of COVID-19 mortality. This study explored the factors mediating this association and whether older age was associated with increased mortality risk in the absence of other risk factors. Methods In UK Biobank, a population cohort study, baseline data were linked to COVID-19 deaths. Poisson regression was used to study the association between current age and COVID-19 mortality. Results Among eligible participants, 438 (0.09%) died of COVID-19. Current age was associated exponentially with COVID-19 mortality. Overall, participants aged ≥75 years were at 13-fold (95% CI 9.13–17.85) mortality risk compared with those <65 years. Low forced expiratory volume in 1 second, high systolic blood pressure, low handgrip strength, and multiple long-term conditions were significant mediators, and collectively explained 39.3% of their excess risk. The associations between these risk factors and COVID-19 mortality were stronger among older participants. Participants aged ≥75 without additional risk factors were at 4-fold risk (95% CI 1.57–9.96, P = 0.004) compared with all participants aged <65 years. Conclusions Higher COVID-19 mortality among older adults was partially explained by other risk factors. ‘Healthy’ older adults were at much lower risk. Nonetheless, older age was an independent risk factor for COVID-19 mortality.

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BMI and all-cause mortality among middle-aged and older adults in Taiwan: a population-based cohort study

Public Health Nutrition ◽

10.1017/s136898001400281x ◽

2014 ◽

Vol 18 (10) ◽

pp. 1839-1846 ◽

Cited By ~ 13

Author(s):

Wei-Sheng Chung ◽

Feng-Ming Ho ◽

Nan-Cheng Cheng ◽

Meng-Chih Lee ◽

Chih-Jung Yeh

Keyword(s):

Older Adults ◽

Cohort Study ◽

Population Based ◽

Normal Weight ◽

Hazard Ratio ◽

Adjusted Hazard Ratio ◽

Middle Aged ◽

Obese People ◽

Risk Of Death ◽

All Cause Mortality

AbstractObjectiveThe present study investigates the relationship between BMI and all-cause mortality among middle-aged and older adults with or without pre-existing diseases.DesignA population-based cohort study.SettingThe Taiwan Longitudinal Study on Aging is a nationwide prospective cohort study comprising a representative random sample of middle-aged and older adults. The study period was 1996–2007.SubjectsWe followed 4145 middle-aged and older adults, totalling 42 353 person-years.ResultsOverweight and mildly obese participants showed a 16 % and 30 % decrease in the risk of death, respectively, compared with those of normal weight after adjusting for potential covariates (e.g. demographic characteristics, health behaviour, co-morbidities and physical function). Underweight adults showed a 1·36-fold increased adjusted hazard ratio of death compared with normal-weight adults. Adults with a BMI of 27·0–28·0 kg/m2 showed a significantly lower adjusted hazard ratio of all-cause mortality rate compared with adults who had normal BMI values when they had coexisting hypertension or diabetes (adjusted hazard ratio=0·50; 95 % CI 0·30, 0·81 for hypertension and adjusted hazard ratio=0·41; 95 % CI 0·18, 0·89 for diabetes).ConclusionsThe study demonstrates that underweight people have a higher risk of death, and overweight and mildly obese people have a lower risk of death, compared with people of normal weight among middle-aged and older adults. An optimal BMI may be based on the individual, who exhibits pre-existing diseases or not.

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